Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models
Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and anti-inflammatory activity. Analgesic activity was studied in acetic acid induced writhing...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2011-07, Vol.24 (3), p.369-375 |
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| creator | Sannigrahi, Santanu Mazumder, Upal Kanti Pal, Dilipkumar Mishra, Mishra Lipsa Maity, Subhasis |
| description | Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and anti-inflammatory activity. Analgesic activity was studied in acetic acid induced writhing response and by hot plate method in Swiss albino mice. Anti-inflammatory activity was estimated by carrageenan and histamine induced acute inflammation and Freund's complete adjuvant (FCA) induced chronic inflammation in rats. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Oral administration of TFEF at the doses of 200 and 400 mg/kg provide 27.05 and 55.49% protection respectively in acetic acid induced writhing method. It also increased the pain threshold in mice evidenced by hot plate method. TFEF showed more potent anti-inflammatory activity. The results of this study may be attributed to high free radical scavenging and antioxidant potential of the flavonoids present in ethyl acetate fraction of Enhydra fluctuans. |
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Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and anti-inflammatory activity. Analgesic activity was studied in acetic acid induced writhing response and by hot plate method in Swiss albino mice. Anti-inflammatory activity was estimated by carrageenan and histamine induced acute inflammation and Freund's complete adjuvant (FCA) induced chronic inflammation in rats. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Oral administration of TFEF at the doses of 200 and 400 mg/kg provide 27.05 and 55.49% protection respectively in acetic acid induced writhing method. It also increased the pain threshold in mice evidenced by hot plate method. TFEF showed more potent anti-inflammatory activity. The results of this study may be attributed to high free radical scavenging and antioxidant potential of the flavonoids present in ethyl acetate fraction of Enhydra fluctuans.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 21715271</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject><![CDATA[Acetates - chemistry ; Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Asteraceae - chemistry ; Bioflavonoids ; Care and treatment ; Chemical properties ; Compositae ; Disaccharides - chemistry ; Disaccharides - isolation & purification ; Disease Models, Animal ; Drug Evaluation, Preclinical - methods ; Flavones ; Flavones - chemistry ; Flavones - isolation & purification ; Flavonoids ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Glucosides - chemistry ; Glucosides - isolation & purification ; Health aspects ; Inflammation ; Inflammation - chemically induced ; Inflammation - drug therapy ; Male ; Materia medica, Vegetable ; Mice ; Pain ; Pain Measurement - drug effects ; Pain Measurement - methods ; Pain Threshold - drug effects ; Phytotherapy - methods ; Plant Components, Aerial - chemistry ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar]]></subject><ispartof>Pakistan journal of pharmaceutical sciences, 2011-07, Vol.24 (3), p.369-375</ispartof><rights>COPYRIGHT 2011 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21715271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sannigrahi, Santanu</creatorcontrib><creatorcontrib>Mazumder, Upal Kanti</creatorcontrib><creatorcontrib>Pal, Dilipkumar</creatorcontrib><creatorcontrib>Mishra, Mishra Lipsa</creatorcontrib><creatorcontrib>Maity, Subhasis</creatorcontrib><title>Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and anti-inflammatory activity. Analgesic activity was studied in acetic acid induced writhing response and by hot plate method in Swiss albino mice. Anti-inflammatory activity was estimated by carrageenan and histamine induced acute inflammation and Freund's complete adjuvant (FCA) induced chronic inflammation in rats. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Oral administration of TFEF at the doses of 200 and 400 mg/kg provide 27.05 and 55.49% protection respectively in acetic acid induced writhing method. It also increased the pain threshold in mice evidenced by hot plate method. TFEF showed more potent anti-inflammatory activity. The results of this study may be attributed to high free radical scavenging and antioxidant potential of the flavonoids present in ethyl acetate fraction of Enhydra fluctuans.</description><subject>Acetates - chemistry</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Asteraceae - chemistry</subject><subject>Bioflavonoids</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Compositae</subject><subject>Disaccharides - chemistry</subject><subject>Disaccharides - isolation & purification</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Flavones</subject><subject>Flavones - chemistry</subject><subject>Flavones - isolation & purification</subject><subject>Flavonoids</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>Flavonoids - therapeutic use</subject><subject>Glucosides - chemistry</subject><subject>Glucosides - isolation & purification</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Male</subject><subject>Materia medica, Vegetable</subject><subject>Mice</subject><subject>Pain</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Measurement - methods</subject><subject>Pain Threshold - drug effects</subject><subject>Phytotherapy - methods</subject><subject>Plant Components, Aerial - chemistry</subject><subject>Plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LxDAQhntQ3HX1L0jAg6dK89GmPS7LrgoLXhS8lTSZ7EbSZG3Sxf57I64HQYZhhpdnhnnnLJvjAuO8KvDbLLsM4b0oKtY0zUU2I5jjknA8z-zGiqN33qiAvEZrt5_UINDGjjKOwgUEn3vTmRiQcMLuIBiZOpUymtw4bUXfi-iHCQkZzdHECRmHlNEaBnAxcaYXFvVegQ1X2bkWNsD1qS6y1836ZfWYb58fnlbLbb4jnMe8UoXuoBZdKRUDhbVuKkpIB6TGvFKcM8JLSigrkiqZqppkhdZ1qSXjpSjpIrv72XsY_McIIba9CRKsFQ78GNqaM1bTgvFE3v6QO2GhTX58HIT8ptslaVjd1CWlibr_h0qhoDfSO9Am6X8Gbk4HjF0Pqj0M6QvD1P7-nX4B4dx9kQ</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Sannigrahi, Santanu</creator><creator>Mazumder, Upal Kanti</creator><creator>Pal, Dilipkumar</creator><creator>Mishra, Mishra Lipsa</creator><creator>Maity, Subhasis</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models</title><author>Sannigrahi, Santanu ; Mazumder, Upal Kanti ; Pal, Dilipkumar ; Mishra, Mishra Lipsa ; Maity, Subhasis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g277t-6d0fbe8ab5cd4ed1ff96322be28176d77427532340322c4d692713885fc475a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetates - chemistry</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Asteraceae - chemistry</topic><topic>Bioflavonoids</topic><topic>Care and treatment</topic><topic>Chemical properties</topic><topic>Compositae</topic><topic>Disaccharides - chemistry</topic><topic>Disaccharides - isolation & purification</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Flavones</topic><topic>Flavones - chemistry</topic><topic>Flavones - isolation & purification</topic><topic>Flavonoids</topic><topic>Flavonoids - isolation & purification</topic><topic>Flavonoids - pharmacology</topic><topic>Flavonoids - therapeutic use</topic><topic>Glucosides - chemistry</topic><topic>Glucosides - isolation & purification</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Male</topic><topic>Materia medica, Vegetable</topic><topic>Mice</topic><topic>Pain</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Measurement - methods</topic><topic>Pain Threshold - drug effects</topic><topic>Phytotherapy - methods</topic><topic>Plant Components, Aerial - chemistry</topic><topic>Plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sannigrahi, Santanu</creatorcontrib><creatorcontrib>Mazumder, Upal Kanti</creatorcontrib><creatorcontrib>Pal, Dilipkumar</creatorcontrib><creatorcontrib>Mishra, Mishra Lipsa</creatorcontrib><creatorcontrib>Maity, Subhasis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sannigrahi, Santanu</au><au>Mazumder, Upal Kanti</au><au>Pal, Dilipkumar</au><au>Mishra, Mishra Lipsa</au><au>Maity, Subhasis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2011-07</date><risdate>2011</risdate><volume>24</volume><issue>3</issue><spage>369</spage><epage>375</epage><pages>369-375</pages><issn>1011-601X</issn><abstract>Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and anti-inflammatory activity. Analgesic activity was studied in acetic acid induced writhing response and by hot plate method in Swiss albino mice. Anti-inflammatory activity was estimated by carrageenan and histamine induced acute inflammation and Freund's complete adjuvant (FCA) induced chronic inflammation in rats. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Oral administration of TFEF at the doses of 200 and 400 mg/kg provide 27.05 and 55.49% protection respectively in acetic acid induced writhing method. It also increased the pain threshold in mice evidenced by hot plate method. TFEF showed more potent anti-inflammatory activity. The results of this study may be attributed to high free radical scavenging and antioxidant potential of the flavonoids present in ethyl acetate fraction of Enhydra fluctuans.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>21715271</pmid><tpages>7</tpages></addata></record> |
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| subjects | Acetates - chemistry Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - isolation & purification Antioxidants - pharmacology Antioxidants - therapeutic use Asteraceae - chemistry Bioflavonoids Care and treatment Chemical properties Compositae Disaccharides - chemistry Disaccharides - isolation & purification Disease Models, Animal Drug Evaluation, Preclinical - methods Flavones Flavones - chemistry Flavones - isolation & purification Flavonoids Flavonoids - isolation & purification Flavonoids - pharmacology Flavonoids - therapeutic use Glucosides - chemistry Glucosides - isolation & purification Health aspects Inflammation Inflammation - chemically induced Inflammation - drug therapy Male Materia medica, Vegetable Mice Pain Pain Measurement - drug effects Pain Measurement - methods Pain Threshold - drug effects Phytotherapy - methods Plant Components, Aerial - chemistry Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar |
| title | Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models |
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