Rock bream ( Oplegnathus fasciatus) serpin, protease nexin-1: Transcriptional analysis and characterization of its antiprotease and anticoagulant activities

Protease nexin-1 (PN-1) is a serine protease inhibitor (SERPIN) protein with functional roles in growth, development, patho-physiology and injury. Here, we report our work to clone, analyze the expression profile and characterize the properties of the PN-1 gene in rock bream (Rb), Oplegnathus fascia...

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Veröffentlicht in:	Developmental and comparative immunology 2011-07, Vol.35 (7), p.785-798
Hauptverfasser:	Umasuthan, Navaneethaiyer, Whang, Ilson, Kim, Jong-Oh, Oh, Myung-Joo, Jung, Sung-Ju, Choi, Cheol Young, Yeo, Sang-Yeob, Lee, Jeong-Ho, Noh, Jae Koo, Lee, Jehee
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites amino acids Animals anticoagulant activity anticoagulants Anticoagulants - pharmacology Anticoagulation Antiprotease activity binding sites bream Cells, Cultured Cloning, Molecular DNA Virus Infections - genetics DNA Virus Infections - metabolism dose response Edwardsiella tarda Edwardsiella tarda - pathogenicity Enterobacteriaceae Infections - genetics Enterobacteriaceae Infections - metabolism Fishes Gasterosteus aculeatus gene expression Gene Expression Profiling gene expression regulation genes heparin Humans immunity in vivo studies Injury Iridovirus Iridovirus - pathogenicity lipopolysaccharides Marine messenger RNA molecular weight Oplegnathus fasciatus Partial Thromboplastin Time Phylogeny Plasminogen Activator Inhibitor 1 - genetics plasminogen activator inhibitors Protease Inhibitors - pharmacology Protease nexin-1 proteinase inhibitors quantitative polymerase chain reaction Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Rock bream Sequence Homology Serpin Serpin E2 - genetics Serpin E2 - metabolism signal peptide Tetraodon nigroviridis thrombin thromboplastin tissues Transcription transcription (genetics) trypsin
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