Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations
Background: Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein. Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superan...
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| Veröffentlicht in: | Multiple sclerosis 2011-04, Vol.17 (4), p.397-403 |
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| creator | Mulvey, Michael R Doupe, Malcolm Prout, Michael Leong, Christine Hizon, Romeo Grossberndt, Amy Klowak, Meghann Gupta, Aneri Melanson, Maria Gomori, Andrew Esfahani, Farid Klassen, Loressa Frost, Emma E Namaka, Michael |
| description | Background:
Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein.
Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superantigens.
Methods: Nasal swabs were collected from non-MS subjects and patients with MS who had not experienced a relapse in the past six months (MS stable group) and who had suffered a relapse within 30 days of study recruitment (MS exacerbation group). S. aureus was isolated from the anterior nares of participants following standard procedures and staphylococcal superantigen genes (sea, seb, and tsst-1) were detected using standard laboratory PCR techniques.
Results: The study enrolled 204 patients, 80 in the non-MS and MS stable groups and 44 patients in the MS exacerbation group. Overall, 27.0% of patients were colonized with S. aureus with no significant differences identified between study groups. Amongst individuals colonized with S. aureus, the prevalence of sea was significantly greater in the MS exacerbation versus non-MS study group (p |
| doi_str_mv | 10.1177/1352458510391343 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_874197080</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1352458510391343</sage_id><sourcerecordid>862004224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-c557e46d57d0d565ff5ad05b75b712501dda4d2b361c97fe68601ddfa7fba3853</originalsourceid><addsrcrecordid>eNqFkc9rFTEQx4Mo9ofePUkQpKetSTY_9h1LaatQ8KCel9ls0qbubtbMLrT_vfP6nhYKIkmYkPl8ZzIzjL2T4lRK5z7J2ihtGiNFvZG1rl-wQ6mdq8TGiZd0J3e19R-wI8Q7IYRztXnNDpSkJZrNIRu_LTDfPgzZZ-9X5LCWQOYWSpfXkqYbfjEtoeQl36eJn3EghM8ZMXVD4CXhTx7BL7nwSGdchyXN5EA_kAgT8nAPPpQOlpQnfMNeRRgwvN3bY_bj8uL7-efq-uvVl_Oz68prZZbKG-OCtr1xveiNNTEa6IXpHG2pjJB9D7pXXW2l37gYbGO3bxFc7KBuTH3MTnZx55J_rQGXdkzowzDAFPKKbeO0pBY14v-kVUJopTSRH56Rd9ShicogSDpllbIEiR3kqXosIbZzSSOUh1aKdjuy9vnISPJ-H3ftxtD_FfyZEQEf9wCghyEWmHzCJ04LZ5vH3NWOQ7gJT5_7Z-Lfi3Wrvw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>861726226</pqid></control><display><type>article</type><title>Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Mulvey, Michael R ; Doupe, Malcolm ; Prout, Michael ; Leong, Christine ; Hizon, Romeo ; Grossberndt, Amy ; Klowak, Meghann ; Gupta, Aneri ; Melanson, Maria ; Gomori, Andrew ; Esfahani, Farid ; Klassen, Loressa ; Frost, Emma E ; Namaka, Michael</creator><creatorcontrib>Mulvey, Michael R ; Doupe, Malcolm ; Prout, Michael ; Leong, Christine ; Hizon, Romeo ; Grossberndt, Amy ; Klowak, Meghann ; Gupta, Aneri ; Melanson, Maria ; Gomori, Andrew ; Esfahani, Farid ; Klassen, Loressa ; Frost, Emma E ; Namaka, Michael</creatorcontrib><description>Background:
Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein.
Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superantigens.
Methods: Nasal swabs were collected from non-MS subjects and patients with MS who had not experienced a relapse in the past six months (MS stable group) and who had suffered a relapse within 30 days of study recruitment (MS exacerbation group). S. aureus was isolated from the anterior nares of participants following standard procedures and staphylococcal superantigen genes (sea, seb, and tsst-1) were detected using standard laboratory PCR techniques.
Results: The study enrolled 204 patients, 80 in the non-MS and MS stable groups and 44 patients in the MS exacerbation group. Overall, 27.0% of patients were colonized with S. aureus with no significant differences identified between study groups. Amongst individuals colonized with S. aureus, the prevalence of sea was significantly greater in the MS exacerbation versus non-MS study group (p < 0.05; odds ratio 7.9; 95% confidence interval 1.2–49.5).
Conclusions: The ability to rapidly screen patients for the presence of S. aureus producing sea may serve as a useful marker of a potential MS exacerbation.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/1352458510391343</identifier><identifier>PMID: 21212089</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Enterotoxins - immunology ; Female ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - immunology ; Multiple Sclerosis - microbiology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nasal Cavity - immunology ; Neurology ; Risk Factors ; Staphylococcal Infections - immunology ; Staphylococcus aureus ; Staphylococcus aureus - immunology ; Superantigens - immunology</subject><ispartof>Multiple sclerosis, 2011-04, Vol.17 (4), p.397-403</ispartof><rights>The Author(s) 2011 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>2015 INIST-CNRS</rights><rights>SAGE Publications © Apr 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-c557e46d57d0d565ff5ad05b75b712501dda4d2b361c97fe68601ddfa7fba3853</citedby><cites>FETCH-LOGICAL-c425t-c557e46d57d0d565ff5ad05b75b712501dda4d2b361c97fe68601ddfa7fba3853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1352458510391343$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1352458510391343$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24076826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21212089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mulvey, Michael R</creatorcontrib><creatorcontrib>Doupe, Malcolm</creatorcontrib><creatorcontrib>Prout, Michael</creatorcontrib><creatorcontrib>Leong, Christine</creatorcontrib><creatorcontrib>Hizon, Romeo</creatorcontrib><creatorcontrib>Grossberndt, Amy</creatorcontrib><creatorcontrib>Klowak, Meghann</creatorcontrib><creatorcontrib>Gupta, Aneri</creatorcontrib><creatorcontrib>Melanson, Maria</creatorcontrib><creatorcontrib>Gomori, Andrew</creatorcontrib><creatorcontrib>Esfahani, Farid</creatorcontrib><creatorcontrib>Klassen, Loressa</creatorcontrib><creatorcontrib>Frost, Emma E</creatorcontrib><creatorcontrib>Namaka, Michael</creatorcontrib><title>Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Background:
Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein.
Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superantigens.
Methods: Nasal swabs were collected from non-MS subjects and patients with MS who had not experienced a relapse in the past six months (MS stable group) and who had suffered a relapse within 30 days of study recruitment (MS exacerbation group). S. aureus was isolated from the anterior nares of participants following standard procedures and staphylococcal superantigen genes (sea, seb, and tsst-1) were detected using standard laboratory PCR techniques.
Results: The study enrolled 204 patients, 80 in the non-MS and MS stable groups and 44 patients in the MS exacerbation group. Overall, 27.0% of patients were colonized with S. aureus with no significant differences identified between study groups. Amongst individuals colonized with S. aureus, the prevalence of sea was significantly greater in the MS exacerbation versus non-MS study group (p < 0.05; odds ratio 7.9; 95% confidence interval 1.2–49.5).
Conclusions: The ability to rapidly screen patients for the presence of S. aureus producing sea may serve as a useful marker of a potential MS exacerbation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Enterotoxins - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple Sclerosis - microbiology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nasal Cavity - immunology</subject><subject>Neurology</subject><subject>Risk Factors</subject><subject>Staphylococcal Infections - immunology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - immunology</subject><subject>Superantigens - immunology</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc9rFTEQx4Mo9ofePUkQpKetSTY_9h1LaatQ8KCel9ls0qbubtbMLrT_vfP6nhYKIkmYkPl8ZzIzjL2T4lRK5z7J2ihtGiNFvZG1rl-wQ6mdq8TGiZd0J3e19R-wI8Q7IYRztXnNDpSkJZrNIRu_LTDfPgzZZ-9X5LCWQOYWSpfXkqYbfjEtoeQl36eJn3EghM8ZMXVD4CXhTx7BL7nwSGdchyXN5EA_kAgT8nAPPpQOlpQnfMNeRRgwvN3bY_bj8uL7-efq-uvVl_Oz68prZZbKG-OCtr1xveiNNTEa6IXpHG2pjJB9D7pXXW2l37gYbGO3bxFc7KBuTH3MTnZx55J_rQGXdkzowzDAFPKKbeO0pBY14v-kVUJopTSRH56Rd9ShicogSDpllbIEiR3kqXosIbZzSSOUh1aKdjuy9vnISPJ-H3ftxtD_FfyZEQEf9wCghyEWmHzCJ04LZ5vH3NWOQ7gJT5_7Z-Lfi3Wrvw</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Mulvey, Michael R</creator><creator>Doupe, Malcolm</creator><creator>Prout, Michael</creator><creator>Leong, Christine</creator><creator>Hizon, Romeo</creator><creator>Grossberndt, Amy</creator><creator>Klowak, Meghann</creator><creator>Gupta, Aneri</creator><creator>Melanson, Maria</creator><creator>Gomori, Andrew</creator><creator>Esfahani, Farid</creator><creator>Klassen, Loressa</creator><creator>Frost, Emma E</creator><creator>Namaka, Michael</creator><general>SAGE Publications</general><general>Sage Publications</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20110401</creationdate><title>Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations</title><author>Mulvey, Michael R ; Doupe, Malcolm ; Prout, Michael ; Leong, Christine ; Hizon, Romeo ; Grossberndt, Amy ; Klowak, Meghann ; Gupta, Aneri ; Melanson, Maria ; Gomori, Andrew ; Esfahani, Farid ; Klassen, Loressa ; Frost, Emma E ; Namaka, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-c557e46d57d0d565ff5ad05b75b712501dda4d2b361c97fe68601ddfa7fba3853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Enterotoxins - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple Sclerosis - microbiology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nasal Cavity - immunology</topic><topic>Neurology</topic><topic>Risk Factors</topic><topic>Staphylococcal Infections - immunology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - immunology</topic><topic>Superantigens - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mulvey, Michael R</creatorcontrib><creatorcontrib>Doupe, Malcolm</creatorcontrib><creatorcontrib>Prout, Michael</creatorcontrib><creatorcontrib>Leong, Christine</creatorcontrib><creatorcontrib>Hizon, Romeo</creatorcontrib><creatorcontrib>Grossberndt, Amy</creatorcontrib><creatorcontrib>Klowak, Meghann</creatorcontrib><creatorcontrib>Gupta, Aneri</creatorcontrib><creatorcontrib>Melanson, Maria</creatorcontrib><creatorcontrib>Gomori, Andrew</creatorcontrib><creatorcontrib>Esfahani, Farid</creatorcontrib><creatorcontrib>Klassen, Loressa</creatorcontrib><creatorcontrib>Frost, Emma E</creatorcontrib><creatorcontrib>Namaka, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mulvey, Michael R</au><au>Doupe, Malcolm</au><au>Prout, Michael</au><au>Leong, Christine</au><au>Hizon, Romeo</au><au>Grossberndt, Amy</au><au>Klowak, Meghann</au><au>Gupta, Aneri</au><au>Melanson, Maria</au><au>Gomori, Andrew</au><au>Esfahani, Farid</au><au>Klassen, Loressa</au><au>Frost, Emma E</au><au>Namaka, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>17</volume><issue>4</issue><spage>397</spage><epage>403</epage><pages>397-403</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><abstract>Background:
Staphylococcus aureus may produce superantigens that can non-specifically activate CD4+ cells to potentially target the myelin basic protein.
Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superantigens.
Methods: Nasal swabs were collected from non-MS subjects and patients with MS who had not experienced a relapse in the past six months (MS stable group) and who had suffered a relapse within 30 days of study recruitment (MS exacerbation group). S. aureus was isolated from the anterior nares of participants following standard procedures and staphylococcal superantigen genes (sea, seb, and tsst-1) were detected using standard laboratory PCR techniques.
Results: The study enrolled 204 patients, 80 in the non-MS and MS stable groups and 44 patients in the MS exacerbation group. Overall, 27.0% of patients were colonized with S. aureus with no significant differences identified between study groups. Amongst individuals colonized with S. aureus, the prevalence of sea was significantly greater in the MS exacerbation versus non-MS study group (p < 0.05; odds ratio 7.9; 95% confidence interval 1.2–49.5).
Conclusions: The ability to rapidly screen patients for the presence of S. aureus producing sea may serve as a useful marker of a potential MS exacerbation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21212089</pmid><doi>10.1177/1352458510391343</doi><tpages>7</tpages></addata></record> |
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| ispartof | Multiple sclerosis, 2011-04, Vol.17 (4), p.397-403 |
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| subjects | Adult Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enterotoxins - immunology Female Humans Logistic Models Male Medical sciences Middle Aged Multiple Sclerosis - immunology Multiple Sclerosis - microbiology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nasal Cavity - immunology Neurology Risk Factors Staphylococcal Infections - immunology Staphylococcus aureus Staphylococcus aureus - immunology Superantigens - immunology |
| title | Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations |
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