Effects of three consecutive days exercise on lymphocyte DNA damage in young men
Intense exercise affects the immune system. This study examines effects of three consecutive days of 1 h high-intensity exercise on lymphocyte counts, oxidative DNA damage, and apoptosis in young untrained ( n = 8, 23.8 ± 3.2 years; UT) and endurance-trained ( n = 8, 21.1 ± 3.7 years; TR) subjects...
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| Veröffentlicht in: | European journal of applied physiology 2010-09, Vol.110 (2), p.307-314 |
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| creator | Tanimura, Yuko Shimizu, Kazuhiro Tanabe, Kai Kono, Ichiro Ajisaka, Ryuichi |
| description | Intense exercise affects the immune system. This study examines effects of three consecutive days of 1 h high-intensity exercise on lymphocyte counts, oxidative DNA damage, and apoptosis in young untrained (
n
= 8, 23.8 ± 3.2 years; UT) and endurance-trained (
n
= 8, 21.1 ± 3.7 years; TR) subjects. The subjects performed cycle ergometer exercise at 75%
1 h daily for three consecutive days (exercise session). Blood samples were collected before exercise on the first day of the exercise session (day 1, D1) and at 24 h after the session (day 4, D4). Total lymphocyte counts, a lymphocyte oxidative DNA damage index using Comet assay with human 8-oxoguanine DNA glycosylase, oxidative stress markers, and apoptosis markers were measured. Lymphocyte counts at D1 in TR were significantly lower than in UT. Lymphocyte counts in TR changed little at D4 (from 1,988 ± 475 to 1,854 ± 363 cell/μl), but the lymphocyte counts in UT decreased significantly at D4 (from 2,583 ± 564 to 1,911 ± 528 cell/μl,
P
|
| doi_str_mv | 10.1007/s00421-010-1499-2 |
| format | Article |
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n
= 8, 23.8 ± 3.2 years; UT) and endurance-trained (
n
= 8, 21.1 ± 3.7 years; TR) subjects. The subjects performed cycle ergometer exercise at 75%
1 h daily for three consecutive days (exercise session). Blood samples were collected before exercise on the first day of the exercise session (day 1, D1) and at 24 h after the session (day 4, D4). Total lymphocyte counts, a lymphocyte oxidative DNA damage index using Comet assay with human 8-oxoguanine DNA glycosylase, oxidative stress markers, and apoptosis markers were measured. Lymphocyte counts at D1 in TR were significantly lower than in UT. Lymphocyte counts in TR changed little at D4 (from 1,988 ± 475 to 1,854 ± 363 cell/μl), but the lymphocyte counts in UT decreased significantly at D4 (from 2,583 ± 564 to 1,911 ± 528 cell/μl,
P
< 0.05). Lymphocyte oxidative DNA damage increased concomitantly with exercise sessions in both the groups (UT, from 31.3 ± 17.5 to 48.9 ± 15.7%; TR, from 21.9 ± 5.2 to 62.1 ± 12.5%,
P
< 0.05). Although no change was found in apoptosis markers over time, Annexin-V
+
cells decreased in TR (effect size
D
= 0.8 is large). Three consecutive days of 1 h exercise decreased lymphocyte counts with increased lymphocyte oxidative DNA damage in UT. Lymphocyte counts remained unchanged irrespective of increased oxidative DNA damage in TR. Decreased lymphocyte apoptosis might prevent the decrease of lymphocytes in TR.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-010-1499-2</identifier><identifier>PMID: 20473683</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Age Factors ; Annexin A5 - blood ; Apoptosis ; Biological and medical sciences ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Comet Assay ; DNA Damage ; Exercise ; Exercise Test ; fas Receptor - blood ; Fundamental and applied biological sciences. Psychology ; Human Physiology ; Humans ; Hydrocortisone - blood ; Immune system ; Lymphocyte Count ; Lymphocytes ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Male ; Muscle Contraction ; Muscle, Skeletal - metabolism ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxidative Stress ; Oxygen Consumption ; Sports Medicine ; Superoxides - blood ; Time Factors ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports ; Workloads ; Young Adult</subject><ispartof>European journal of applied physiology, 2010-09, Vol.110 (2), p.307-314</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-3c1c196d3d597eedce2c729dfa985c7d5fd5d5af5b71bbe5a35a324fc42ca6b63</citedby><cites>FETCH-LOGICAL-c519t-3c1c196d3d597eedce2c729dfa985c7d5fd5d5af5b71bbe5a35a324fc42ca6b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-010-1499-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-010-1499-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23187512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20473683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanimura, Yuko</creatorcontrib><creatorcontrib>Shimizu, Kazuhiro</creatorcontrib><creatorcontrib>Tanabe, Kai</creatorcontrib><creatorcontrib>Kono, Ichiro</creatorcontrib><creatorcontrib>Ajisaka, Ryuichi</creatorcontrib><title>Effects of three consecutive days exercise on lymphocyte DNA damage in young men</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Intense exercise affects the immune system. This study examines effects of three consecutive days of 1 h high-intensity exercise on lymphocyte counts, oxidative DNA damage, and apoptosis in young untrained (
n
= 8, 23.8 ± 3.2 years; UT) and endurance-trained (
n
= 8, 21.1 ± 3.7 years; TR) subjects. The subjects performed cycle ergometer exercise at 75%
1 h daily for three consecutive days (exercise session). Blood samples were collected before exercise on the first day of the exercise session (day 1, D1) and at 24 h after the session (day 4, D4). Total lymphocyte counts, a lymphocyte oxidative DNA damage index using Comet assay with human 8-oxoguanine DNA glycosylase, oxidative stress markers, and apoptosis markers were measured. Lymphocyte counts at D1 in TR were significantly lower than in UT. Lymphocyte counts in TR changed little at D4 (from 1,988 ± 475 to 1,854 ± 363 cell/μl), but the lymphocyte counts in UT decreased significantly at D4 (from 2,583 ± 564 to 1,911 ± 528 cell/μl,
P
< 0.05). Lymphocyte oxidative DNA damage increased concomitantly with exercise sessions in both the groups (UT, from 31.3 ± 17.5 to 48.9 ± 15.7%; TR, from 21.9 ± 5.2 to 62.1 ± 12.5%,
P
< 0.05). Although no change was found in apoptosis markers over time, Annexin-V
+
cells decreased in TR (effect size
D
= 0.8 is large). Three consecutive days of 1 h exercise decreased lymphocyte counts with increased lymphocyte oxidative DNA damage in UT. Lymphocyte counts remained unchanged irrespective of increased oxidative DNA damage in TR. Decreased lymphocyte apoptosis might prevent the decrease of lymphocytes in TR.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Annexin A5 - blood</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Comet Assay</subject><subject>DNA Damage</subject><subject>Exercise</subject><subject>Exercise Test</subject><subject>fas Receptor - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Immune system</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Muscle Contraction</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Oxidative Stress</subject><subject>Oxygen Consumption</subject><subject>Sports Medicine</subject><subject>Superoxides - blood</subject><subject>Time Factors</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><subject>Workloads</subject><subject>Young Adult</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kF1LHTEQhoO0-NX-AG8kFKRXW_Ox2WwuRW0riHrRXodsMjmu7Canya50_705nFOFghBIwjzzzvAgdELJN0qIPM-E1IxWhJKK1kpVbA8d0pqrquFMfnh9U3WAjnJ-IoS0jLb76ICRWvKm5Yfo4dp7sFPG0ePpMQFgG0MGO0_9M2BnlozhLyTbZ8Ax4GEZ14_RLhPgq7uLUh_NCnAf8BLnsMIjhE_oozdDhs-7-xj9_n796_JndXv_4-by4raygqqp4pZaqhrHnVASwFlgVjLlvFGtsNIJ74QTxotO0q4DYXg5rPa2ZtY0XcOP0ddt7jrFPzPkSY99tjAMJkCcs25lXfLbhhTyy3_kU5xTKMvpVinaSlqLAtEtZFPMOYHX69SPJi2aEr2RrbeyNdn8i2zNSs_pLnjuRnCvHf_sFuBsB5hszeCTCUXkG8fLcEE3QWzL5VIKK0hvG74__QUb_5a9</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Tanimura, Yuko</creator><creator>Shimizu, Kazuhiro</creator><creator>Tanabe, Kai</creator><creator>Kono, Ichiro</creator><creator>Ajisaka, Ryuichi</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7TM</scope><scope>7TS</scope><scope>H94</scope></search><sort><creationdate>20100901</creationdate><title>Effects of three consecutive days exercise on lymphocyte DNA damage in young men</title><author>Tanimura, Yuko ; Shimizu, Kazuhiro ; Tanabe, Kai ; Kono, Ichiro ; Ajisaka, Ryuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-3c1c196d3d597eedce2c729dfa985c7d5fd5d5af5b71bbe5a35a324fc42ca6b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Annexin A5 - blood</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Comet Assay</topic><topic>DNA Damage</topic><topic>Exercise</topic><topic>Exercise Test</topic><topic>fas Receptor - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Immune system</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Muscle Contraction</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Oxidative Stress</topic><topic>Oxygen Consumption</topic><topic>Sports Medicine</topic><topic>Superoxides - blood</topic><topic>Time Factors</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><topic>Workloads</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanimura, Yuko</creatorcontrib><creatorcontrib>Shimizu, Kazuhiro</creatorcontrib><creatorcontrib>Tanabe, Kai</creatorcontrib><creatorcontrib>Kono, Ichiro</creatorcontrib><creatorcontrib>Ajisaka, Ryuichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanimura, Yuko</au><au>Shimizu, Kazuhiro</au><au>Tanabe, Kai</au><au>Kono, Ichiro</au><au>Ajisaka, Ryuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of three consecutive days exercise on lymphocyte DNA damage in young men</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>110</volume><issue>2</issue><spage>307</spage><epage>314</epage><pages>307-314</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Intense exercise affects the immune system. This study examines effects of three consecutive days of 1 h high-intensity exercise on lymphocyte counts, oxidative DNA damage, and apoptosis in young untrained (
n
= 8, 23.8 ± 3.2 years; UT) and endurance-trained (
n
= 8, 21.1 ± 3.7 years; TR) subjects. The subjects performed cycle ergometer exercise at 75%
1 h daily for three consecutive days (exercise session). Blood samples were collected before exercise on the first day of the exercise session (day 1, D1) and at 24 h after the session (day 4, D4). Total lymphocyte counts, a lymphocyte oxidative DNA damage index using Comet assay with human 8-oxoguanine DNA glycosylase, oxidative stress markers, and apoptosis markers were measured. Lymphocyte counts at D1 in TR were significantly lower than in UT. Lymphocyte counts in TR changed little at D4 (from 1,988 ± 475 to 1,854 ± 363 cell/μl), but the lymphocyte counts in UT decreased significantly at D4 (from 2,583 ± 564 to 1,911 ± 528 cell/μl,
P
< 0.05). Lymphocyte oxidative DNA damage increased concomitantly with exercise sessions in both the groups (UT, from 31.3 ± 17.5 to 48.9 ± 15.7%; TR, from 21.9 ± 5.2 to 62.1 ± 12.5%,
P
< 0.05). Although no change was found in apoptosis markers over time, Annexin-V
+
cells decreased in TR (effect size
D
= 0.8 is large). Three consecutive days of 1 h exercise decreased lymphocyte counts with increased lymphocyte oxidative DNA damage in UT. Lymphocyte counts remained unchanged irrespective of increased oxidative DNA damage in TR. Decreased lymphocyte apoptosis might prevent the decrease of lymphocytes in TR.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20473683</pmid><doi>10.1007/s00421-010-1499-2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of applied physiology, 2010-09, Vol.110 (2), p.307-314 |
| issn | 1439-6319 1439-6327 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Age Factors Annexin A5 - blood Apoptosis Biological and medical sciences Biomarkers - blood Biomedical and Life Sciences Biomedicine Comet Assay DNA Damage Exercise Exercise Test fas Receptor - blood Fundamental and applied biological sciences. Psychology Human Physiology Humans Hydrocortisone - blood Immune system Lymphocyte Count Lymphocytes Lymphocytes - metabolism Lymphocytes - pathology Male Muscle Contraction Muscle, Skeletal - metabolism Occupational Medicine/Industrial Medicine Original Article Oxidative Stress Oxygen Consumption Sports Medicine Superoxides - blood Time Factors Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Workloads Young Adult |
| title | Effects of three consecutive days exercise on lymphocyte DNA damage in young men |
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