Effect of Trichostatin A on Chromatin Remodeling, Histone Modifications, DNA Replication, and Transcriptional Activity in Cloned Mouse Embryos

Our group and others have found that the treatment of embryos with trichostatin A (TSA) after cloning by somatic cell nuclear transfer (SCNT) results in a significant improvement in efficiency. We believe that TSA treatment improves nuclear remodeling via histone modifications, which are important i...

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Veröffentlicht in:	Biology of reproduction 2010-09, Vol.83 (3), p.454-463
Hauptverfasser:	Bui, Hong-Thuy, Wakayama, Sayaka, Kishigami, Satoshi, Park, Keun-Kyu, Kim, Jin-Hoi, Thuan, Nguyen Van, Wakayama, Teruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Analysis of Variance Animals Biological and medical sciences Cell Nucleus - drug effects Cell Nucleus - metabolism Chromatin Assembly and Disassembly - drug effects Clone Cells - metabolism Cloning, Organism DNA Replication - drug effects Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Histones - metabolism Hydroxamic Acids - pharmacology Mice Nuclear Transfer Techniques Oocytes - drug effects Oocytes - metabolism Sperm Injections, Intracytoplasmic Transcription, Genetic - drug effects Vertebrates: reproduction
Online-Zugang:	Volltext
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