Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

The Toll-like receptor 9 (TLR9) evolved to cope with pathogens, but it is expressed in a variety of tumors for reasons that are unclear. In this study, we report that neuroblastoma (NB) cells express functional TLR9. Liposome-complexed CpG oligonucleotides inhibited the proliferation of TLR9-express...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-12, Vol.70 (23), p.9816-9826
Hauptverfasser:	BRIGNOLE, Chiara, MARIMPIETRI, Danilo, ERMINIO, Giovanni, HAUPT, Riccardo, GAMBINI, Claudio, PISTOIA, Vito, PONZONI, Mirco, DI PAOLO, Daniela, PERRI, Patrizia, MORANDI, Fabio, PASTORINO, Fabio, ZORZOLI, Alessia, PAGNAN, Gabriella, LOI, Monica, CAFFA, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Blotting, Western Cell Line, Tumor Cell Proliferation - drug effects Female Gene Expression Regulation, Neoplastic Humans Infant Interleukin Receptor Common gamma Subunit - deficiency Interleukin Receptor Common gamma Subunit - genetics Liposomes - chemistry Medical sciences Mice Mice, Inbred NOD Mice, Knockout Mice, Nude Mice, SCID Neoplasm Staging Neuroblastoma - genetics Neuroblastoma - pathology Neuroblastoma - therapy Neurology Oligodeoxyribonucleotides - genetics Oligodeoxyribonucleotides - pharmacology Oligodeoxyribonucleotides, Antisense - chemistry Oligodeoxyribonucleotides, Antisense - genetics Oligodeoxyribonucleotides, Antisense - pharmacology Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction RNA Interference Survival Analysis Toll-Like Receptor 9 - antagonists & inhibitors Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Tumors Tumors of the nervous system. Phacomatoses Xenograft Model Antitumor Assays
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