Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: Part 1

The observation that 17-cyclopropylmethylmorphinan derivatives without the 4,5-epoxy ring showed more κ selectivity than those with a 4,5-epoxy ring led us to develop a working hypothesis: the position of the plane composed of the A and B rings would influence the opioid receptor type selectivity an...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (13), p.4104-4107
Hauptverfasser:	Yamamoto, Naoshi, Fujii, Hideaki, Nemoto, Toru, Nakajima, Ryo, Momen, Shinobu, Izumimoto, Naoki, Hasebe, Ko, Mochizuki, Hidenori, Nagase, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Analgesics Analgesics, Opioid - chemical synthesis Analgesics, Opioid - chemistry Analgesics, Opioid - pharmacology Animals Biological and medical sciences Bridged-Ring Compounds - chemical synthesis Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - pharmacology Cells, Cultured chemical derivatives Medical sciences Mice Molecular Structure Neuropharmacology pharmacology Pharmacology. Drug treatments Protein Binding - drug effects Receptors, Opioid, kappa - metabolism Structure-Activity Relationship Substrate Specificity synthesis
Online-Zugang:	Volltext
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