Neuromyelitis optica and astrocytic damage in its pathogenesis

Abstract Neuromyelitis optica (NMO) is characterized by severe optic neuritis and longitudinally extended, transverse myelitis. There have been long controversial whether NMO is a variant of multiple sclerosis (MS) or a different disease. However, since the discovery of an NMO-specific autoantibody...

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Veröffentlicht in:	Journal of the neurological sciences 2011-07, Vol.306 (1), p.183-187
1. Verfasser:	Fujihara, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - metabolism Aquaporin 4 Aquaporin 4 - immunology Aquaporin 4 antibody Aquaporins Astrocytes Astrocytes - pathology Astrocytic damage Autoantibodies Central nervous system Cerebrospinal fluid Foot Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - cerebrospinal fluid Glial Fibrillary Acidic Protein - metabolism Humans Immunoreactivity Magnetic Resonance Imaging Multiple sclerosis Myelin basic protein Myelitis Neurology Neuromyelitis Neuromyelitis optica Neuromyelitis Optica - pathology Neuromyelitis Optica - therapy NMO-IgG Optic neuritis Preservation
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