Immune roles of a rhamnose-binding lectin in the colonial ascidian Botryllus schlosseri
Abstract The present paper describes the immune role played by a recently identified ( Gasparini et al. 2008 ) member of the rhamnose-binding lectin (RBL) family from the colonial ascidian Botryllus schlosseri. B. schlosseri RBL (BsRBL) can activate phagocytes through: (i) induction of their directi...
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| Veröffentlicht in: | Immunobiology (1979) 2011-06, Vol.216 (6), p.725-736 |
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| container_title | Immunobiology (1979) |
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| creator | Franchi, Nicola Schiavon, Filippo Carletto, Matteo Gasparini, Fabio Bertoloni, Giulio Tosatto, Silvio C.E Ballarin, Loriano |
| description | Abstract The present paper describes the immune role played by a recently identified ( Gasparini et al. 2008 ) member of the rhamnose-binding lectin (RBL) family from the colonial ascidian Botryllus schlosseri. B. schlosseri RBL (BsRBL) can activate phagocytes through: (i) induction of their directional movement towards the source of the molecule; (ii) modification of cytoskeleton, required for shape changes; (iii) stimulation of the respiratory burst, and consequent production of reactive oxygen species (ROS) with microbicidal activity, including superoxide anions and peroxides; and (iv) increase in the ability to phagocytose foreign particles. RBL also induces the synthesis and release, by cytotoxic morula cells (MCs), of cytokines recognised by anti-IL1α and anti-TNFα antibodies. At high concentrations, BsRBL induces degranulation of MCs and the consequent release of the cytotoxic enzyme phenoloxidase into the medium. Results are consistent with the existence of cross-talk between B. schlosseri immunocytes (phagocytes and MCs). In addition, a three-dimensional model for BsRBL is presented. |
| doi_str_mv | 10.1016/j.imbio.2010.10.011 |
| format | Article |
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B. schlosseri RBL (BsRBL) can activate phagocytes through: (i) induction of their directional movement towards the source of the molecule; (ii) modification of cytoskeleton, required for shape changes; (iii) stimulation of the respiratory burst, and consequent production of reactive oxygen species (ROS) with microbicidal activity, including superoxide anions and peroxides; and (iv) increase in the ability to phagocytose foreign particles. RBL also induces the synthesis and release, by cytotoxic morula cells (MCs), of cytokines recognised by anti-IL1α and anti-TNFα antibodies. At high concentrations, BsRBL induces degranulation of MCs and the consequent release of the cytotoxic enzyme phenoloxidase into the medium. Results are consistent with the existence of cross-talk between B. schlosseri immunocytes (phagocytes and MCs). In addition, a three-dimensional model for BsRBL is presented.</description><identifier>ISSN: 0171-2985</identifier><identifier>EISSN: 1878-3279</identifier><identifier>DOI: 10.1016/j.imbio.2010.10.011</identifier><identifier>PMID: 21112664</identifier><language>eng</language><publisher>Netherlands: Elsevier GmbH</publisher><subject>Advanced Basic Science ; Agglutination - drug effects ; Agglutination - immunology ; Allergy and Immunology ; Amino Acid Sequence ; Animals ; Bacteria - drug effects ; Bacteria - immunology ; Botryllus ; Botryllus schlosseri ; Cell Degranulation - drug effects ; Cell Degranulation - immunology ; Cells, Cultured ; Compound ascidians ; Erythrocytes - drug effects ; Erythrocytes - immunology ; Haemocytes ; Interleukin-1alpha - immunology ; Lectins - chemistry ; Lectins - immunology ; Lectins - metabolism ; Lectins - pharmacology ; Models, Molecular ; Molecular Sequence Data ; Phagocytes - drug effects ; Phagocytes - metabolism ; Protein Binding - physiology ; Protein Conformation ; Rabbits ; Rhamnose - immunology ; Rhamnose - metabolism ; Rhamnose-binding lectin ; Sequence Alignment ; Tumor Necrosis Factor-alpha - immunology ; Tunicates ; Urochordata - immunology ; Urochordata - metabolism ; Yeasts - drug effects ; Yeasts - immunology</subject><ispartof>Immunobiology (1979), 2011-06, Vol.216 (6), p.725-736</ispartof><rights>Elsevier GmbH</rights><rights>2010 Elsevier GmbH</rights><rights>Copyright © 2010 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-1b9e79832d441d31f69351999ebe6cd9037bfaa396d0bdcf4e3ad375f55932063</citedby><cites>FETCH-LOGICAL-c445t-1b9e79832d441d31f69351999ebe6cd9037bfaa396d0bdcf4e3ad375f55932063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0171298510001993$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21112664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franchi, Nicola</creatorcontrib><creatorcontrib>Schiavon, Filippo</creatorcontrib><creatorcontrib>Carletto, Matteo</creatorcontrib><creatorcontrib>Gasparini, Fabio</creatorcontrib><creatorcontrib>Bertoloni, Giulio</creatorcontrib><creatorcontrib>Tosatto, Silvio C.E</creatorcontrib><creatorcontrib>Ballarin, Loriano</creatorcontrib><title>Immune roles of a rhamnose-binding lectin in the colonial ascidian Botryllus schlosseri</title><title>Immunobiology (1979)</title><addtitle>Immunobiology</addtitle><description>Abstract The present paper describes the immune role played by a recently identified ( Gasparini et al. 2008 ) member of the rhamnose-binding lectin (RBL) family from the colonial ascidian Botryllus schlosseri. B. schlosseri RBL (BsRBL) can activate phagocytes through: (i) induction of their directional movement towards the source of the molecule; (ii) modification of cytoskeleton, required for shape changes; (iii) stimulation of the respiratory burst, and consequent production of reactive oxygen species (ROS) with microbicidal activity, including superoxide anions and peroxides; and (iv) increase in the ability to phagocytose foreign particles. RBL also induces the synthesis and release, by cytotoxic morula cells (MCs), of cytokines recognised by anti-IL1α and anti-TNFα antibodies. At high concentrations, BsRBL induces degranulation of MCs and the consequent release of the cytotoxic enzyme phenoloxidase into the medium. Results are consistent with the existence of cross-talk between B. schlosseri immunocytes (phagocytes and MCs). In addition, a three-dimensional model for BsRBL is presented.</description><subject>Advanced Basic Science</subject><subject>Agglutination - drug effects</subject><subject>Agglutination - immunology</subject><subject>Allergy and Immunology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - immunology</subject><subject>Botryllus</subject><subject>Botryllus schlosseri</subject><subject>Cell Degranulation - drug effects</subject><subject>Cell Degranulation - immunology</subject><subject>Cells, Cultured</subject><subject>Compound ascidians</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - immunology</subject><subject>Haemocytes</subject><subject>Interleukin-1alpha - immunology</subject><subject>Lectins - chemistry</subject><subject>Lectins - immunology</subject><subject>Lectins - metabolism</subject><subject>Lectins - pharmacology</subject><subject>Models, Molecular</subject><subject>Molecular Sequence Data</subject><subject>Phagocytes - drug effects</subject><subject>Phagocytes - metabolism</subject><subject>Protein Binding - physiology</subject><subject>Protein Conformation</subject><subject>Rabbits</subject><subject>Rhamnose - immunology</subject><subject>Rhamnose - metabolism</subject><subject>Rhamnose-binding lectin</subject><subject>Sequence Alignment</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tunicates</subject><subject>Urochordata - immunology</subject><subject>Urochordata - metabolism</subject><subject>Yeasts - drug effects</subject><subject>Yeasts - immunology</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9rb6CwTJztVcc5L5ykJBi9ZCwUUVlyGTnPHmmklqMiPcf99Mb-2im0IgcHjeE_K8hLwBtgUG7fv91k2Di1vO7iZbBvCMbKDv-krwTj4nGwYdVFz2zQk5zXnPGEje9S_JCQcA3rb1hvy6nKYlIE3RY6ZxpJqmnZ5CzFgNLlgXflOPZnaBljPvkJroY3DaU52Ns04H-jnO6eD9kmk2Ox9zxuRekRej9hlf399n5OfXLz_Ov1VX3y8uzz9dVaaum7mCQWIne8FtXYMVMLZSNCClxAFbYyUT3TBqLWRr2WDNWKPQVnTN2DRScNaKM_LuuPcmxb8L5llNLhv0XgeMS1Z9V4MUdVc_TbYN9FJIXkhxJE0qn0k4qpvkJp0OCpha1au9ulOvVvXrsKgvqbf3-5dhQvuQ-e-6AB-OABYf_xwmVQRiMGhdKoaVje6JBz4-yhvvgjPa_8ED5n1cUiiqFajMFVPXa_tr-cDW4qUQt9VPqoE</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Franchi, Nicola</creator><creator>Schiavon, Filippo</creator><creator>Carletto, Matteo</creator><creator>Gasparini, Fabio</creator><creator>Bertoloni, Giulio</creator><creator>Tosatto, Silvio C.E</creator><creator>Ballarin, Loriano</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110601</creationdate><title>Immune roles of a rhamnose-binding lectin in the colonial ascidian Botryllus schlosseri</title><author>Franchi, Nicola ; 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B. schlosseri RBL (BsRBL) can activate phagocytes through: (i) induction of their directional movement towards the source of the molecule; (ii) modification of cytoskeleton, required for shape changes; (iii) stimulation of the respiratory burst, and consequent production of reactive oxygen species (ROS) with microbicidal activity, including superoxide anions and peroxides; and (iv) increase in the ability to phagocytose foreign particles. RBL also induces the synthesis and release, by cytotoxic morula cells (MCs), of cytokines recognised by anti-IL1α and anti-TNFα antibodies. At high concentrations, BsRBL induces degranulation of MCs and the consequent release of the cytotoxic enzyme phenoloxidase into the medium. Results are consistent with the existence of cross-talk between B. schlosseri immunocytes (phagocytes and MCs). In addition, a three-dimensional model for BsRBL is presented.</abstract><cop>Netherlands</cop><pub>Elsevier GmbH</pub><pmid>21112664</pmid><doi>10.1016/j.imbio.2010.10.011</doi><tpages>12</tpages></addata></record> |
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| subjects | Advanced Basic Science Agglutination - drug effects Agglutination - immunology Allergy and Immunology Amino Acid Sequence Animals Bacteria - drug effects Bacteria - immunology Botryllus Botryllus schlosseri Cell Degranulation - drug effects Cell Degranulation - immunology Cells, Cultured Compound ascidians Erythrocytes - drug effects Erythrocytes - immunology Haemocytes Interleukin-1alpha - immunology Lectins - chemistry Lectins - immunology Lectins - metabolism Lectins - pharmacology Models, Molecular Molecular Sequence Data Phagocytes - drug effects Phagocytes - metabolism Protein Binding - physiology Protein Conformation Rabbits Rhamnose - immunology Rhamnose - metabolism Rhamnose-binding lectin Sequence Alignment Tumor Necrosis Factor-alpha - immunology Tunicates Urochordata - immunology Urochordata - metabolism Yeasts - drug effects Yeasts - immunology |
| title | Immune roles of a rhamnose-binding lectin in the colonial ascidian Botryllus schlosseri |
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