Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma
Disappearance of normal bone marrow (BM) plasma cells (PC) predicts malignant transformation of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) into symptomatic multiple myeloma (MM). The homing, behavior and survival of normal PC, but also CD34 + hematopoietic...
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| creator | Paiva, B Pérez-Andrés, M Vídriales, M-B Almeida, J de las Heras, N Mateos, M-V López-Corral, L Gutiérrez, N C Blanco, J Oriol, A Hernández, M T de Arriba, F de Coca, A G Terol, M-J de la Rubia, J González, Y Martín, A Sureda, A Schmidt-Hieber, M Schmitz, A Johnsen, H E Lahuerta, J-J Bladé, J San-Miguel, J F Orfao, A |
| description | Disappearance of normal bone marrow (BM) plasma cells (PC) predicts malignant transformation of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) into symptomatic multiple myeloma (MM). The homing, behavior and survival of normal PC, but also CD34
+
hematopoietic stem cells (HSC), B-cell precursors, and clonal PC largely depends on their interaction with stromal cell-derived factor-1 (SDF-1) expressing, potentially overlapping BM stromal cell niches. Here, we investigate the distribution, phenotypic characteristics and competitive migration capacity of these cell populations in patients with MGUS, SMM and MM vs healthy adults (HA) aged >60 years. Our results show that BM and peripheral blood (PB) clonal PC progressively increase from MGUS to MM, the latter showing a slightly more immature immunophenotype. Of note, such increased number of clonal PC is associated with progressive depletion of normal PC, B-cell precursors and CD34
+
HSC in the BM, also with a parallel increase in PB. In an
ex vivo
model, normal PC, B-cell precursors and CD34
+
HSC from MGUS and SMM, but not MM patients, were able to abrogate the migration of clonal PC into serial concentrations of SDF-1. Overall, our results show that progressive competition and replacement of normal BM cells by clonal PC is associated with more advanced disease in patients with MGUS, SMM and MM. |
| doi_str_mv | 10.1038/leu.2010.320 |
| format | Article |
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+
hematopoietic stem cells (HSC), B-cell precursors, and clonal PC largely depends on their interaction with stromal cell-derived factor-1 (SDF-1) expressing, potentially overlapping BM stromal cell niches. Here, we investigate the distribution, phenotypic characteristics and competitive migration capacity of these cell populations in patients with MGUS, SMM and MM vs healthy adults (HA) aged >60 years. Our results show that BM and peripheral blood (PB) clonal PC progressively increase from MGUS to MM, the latter showing a slightly more immature immunophenotype. Of note, such increased number of clonal PC is associated with progressive depletion of normal PC, B-cell precursors and CD34
+
HSC in the BM, also with a parallel increase in PB. In an
ex vivo
model, normal PC, B-cell precursors and CD34
+
HSC from MGUS and SMM, but not MM patients, were able to abrogate the migration of clonal PC into serial concentrations of SDF-1. Overall, our results show that progressive competition and replacement of normal BM cells by clonal PC is associated with more advanced disease in patients with MGUS, SMM and MM.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2010.320</identifier><identifier>PMID: 21252988</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/1619/40/1742 ; 631/250/1620/1342 ; 692/699/249/1573 ; 692/699/67/1990/804 ; Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes - cytology ; B-Lymphocytes - metabolism ; Benign monoclonal gammopathy ; Biological and medical sciences ; Bone marrow ; Bone Marrow Cells - cytology ; Bone Marrow Cells - metabolism ; Cancer Research ; Case-Control Studies ; CD34 antigen ; Cell Movement ; Cells, Cultured ; Clone Cells ; Competition ; Critical Care Medicine ; Depletion ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Genetic aspects ; Hematologic and hematopoietic diseases ; Hematology ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - metabolism ; Homing behavior ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Immunophenotyping ; Intensive ; Internal Medicine ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes B ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple myeloma ; Multiple Myeloma - metabolism ; Multiple Myeloma - pathology ; Oncology ; original-article ; Paraproteinemias - metabolism ; Paraproteinemias - pathology ; Peripheral blood ; Physiological aspects ; Plasma cells ; Plasma Cells - cytology ; Plasma Cells - metabolism ; Precursors ; Prospective Studies ; Risk factors ; SDF-1 protein ; Smoldering ; Stem cells</subject><ispartof>Leukemia, 2011-04, Vol.25 (4), p.697-706</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2011.</rights><rights>Copyright Nature Publishing Group Apr 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-2f77f858f434fcfc64f46082074d61ee32d3d89fe7e4f66b958aba6feacc5d6c3</citedby><cites>FETCH-LOGICAL-c581t-2f77f858f434fcfc64f46082074d61ee32d3d89fe7e4f66b958aba6feacc5d6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2010.320$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2010.320$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24105109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21252988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paiva, B</creatorcontrib><creatorcontrib>Pérez-Andrés, M</creatorcontrib><creatorcontrib>Vídriales, M-B</creatorcontrib><creatorcontrib>Almeida, J</creatorcontrib><creatorcontrib>de las Heras, N</creatorcontrib><creatorcontrib>Mateos, M-V</creatorcontrib><creatorcontrib>López-Corral, L</creatorcontrib><creatorcontrib>Gutiérrez, N C</creatorcontrib><creatorcontrib>Blanco, J</creatorcontrib><creatorcontrib>Oriol, A</creatorcontrib><creatorcontrib>Hernández, M T</creatorcontrib><creatorcontrib>de Arriba, F</creatorcontrib><creatorcontrib>de Coca, A G</creatorcontrib><creatorcontrib>Terol, M-J</creatorcontrib><creatorcontrib>de la Rubia, J</creatorcontrib><creatorcontrib>González, Y</creatorcontrib><creatorcontrib>Martín, A</creatorcontrib><creatorcontrib>Sureda, A</creatorcontrib><creatorcontrib>Schmidt-Hieber, M</creatorcontrib><creatorcontrib>Schmitz, A</creatorcontrib><creatorcontrib>Johnsen, H E</creatorcontrib><creatorcontrib>Lahuerta, J-J</creatorcontrib><creatorcontrib>Bladé, J</creatorcontrib><creatorcontrib>San-Miguel, J F</creatorcontrib><creatorcontrib>Orfao, A</creatorcontrib><creatorcontrib>GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas)</creatorcontrib><creatorcontrib>Myeloma Stem Cell Network (MSCNET)</creatorcontrib><creatorcontrib>on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study groups and the Myeloma Stem Cell Network (MSCNET)</creatorcontrib><title>Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Disappearance of normal bone marrow (BM) plasma cells (PC) predicts malignant transformation of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) into symptomatic multiple myeloma (MM). The homing, behavior and survival of normal PC, but also CD34
+
hematopoietic stem cells (HSC), B-cell precursors, and clonal PC largely depends on their interaction with stromal cell-derived factor-1 (SDF-1) expressing, potentially overlapping BM stromal cell niches. Here, we investigate the distribution, phenotypic characteristics and competitive migration capacity of these cell populations in patients with MGUS, SMM and MM vs healthy adults (HA) aged >60 years. Our results show that BM and peripheral blood (PB) clonal PC progressively increase from MGUS to MM, the latter showing a slightly more immature immunophenotype. Of note, such increased number of clonal PC is associated with progressive depletion of normal PC, B-cell precursors and CD34
+
HSC in the BM, also with a parallel increase in PB. In an
ex vivo
model, normal PC, B-cell precursors and CD34
+
HSC from MGUS and SMM, but not MM patients, were able to abrogate the migration of clonal PC into serial concentrations of SDF-1. Overall, our results show that progressive competition and replacement of normal BM cells by clonal PC is associated with more advanced disease in patients with MGUS, SMM and MM.</description><subject>631/250/1619/40/1742</subject><subject>631/250/1620/1342</subject><subject>692/699/249/1573</subject><subject>692/699/67/1990/804</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Benign monoclonal gammopathy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>CD34 antigen</subject><subject>Cell Movement</subject><subject>Cells, Cultured</subject><subject>Clone Cells</subject><subject>Competition</subject><subject>Critical Care Medicine</subject><subject>Depletion</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Genetic aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Homing behavior</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Immunophenotyping</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - metabolism</subject><subject>Multiple Myeloma - pathology</subject><subject>Oncology</subject><subject>original-article</subject><subject>Paraproteinemias - metabolism</subject><subject>Paraproteinemias - pathology</subject><subject>Peripheral blood</subject><subject>Physiological aspects</subject><subject>Plasma cells</subject><subject>Plasma Cells - cytology</subject><subject>Plasma Cells - metabolism</subject><subject>Precursors</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>SDF-1 protein</subject><subject>Smoldering</subject><subject>Stem cells</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFksFu1DAQhiMEokvhxhlZVMCFLLZjO8mxWkFBKuIAPUeOM9515djBTnbVZ-PlcLoLS1ER8sHyzOff45k_y54TvCS4qN5ZmJYUp1NB8YNsQVgpcs45eZgtcFWVuagpO8mexHiN8ZwUj7MTSiindVUtsh8r3w8wmtF4h1oYdwAOKeudtGiwMvYSKbA2Iuk65HzoU3wf0D6gwY_gRiOtvUF-C8HKYTBujVrvAPUyBL9DzqgNRGSSRIxeGTlCh3Zm3CCJhuDXAWI0W0gK0o4QUnLWn6wMqDNxDKadboszDn2-uPqKthH1N2B9L59mj7S0EZ4d9tPs6sP7b6uP-eWXi0-r88tc8YqMOdVlqSteaVYwrbQSTDOBK4pL1gkCUNCu6KpaQwlMC9HWvJKtFBqkUrwTqjjN3ux1U7nfJ4hj05s4Fykd-Ck2VclITTGn_ycFxZgTIRL58i_y2k8hdX2GiMC0LEiCzv4FUcF4WdCyZEdqLS00xmk_Bqnmh5tzyhmvWY1nreU9VFod9EaleWmT4ncuvP7jwgbSdDbR29thxLvg2z2ogo8xgG6GYNLwbxqCm9miTbJoM1u0SRZN-IvDp6a2h-43_MuTCXh1AGRU0uognTLxyDGSWojrxOV7LqaUW0M4dufeh38CAYn_DA</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Paiva, B</creator><creator>Pérez-Andrés, M</creator><creator>Vídriales, M-B</creator><creator>Almeida, J</creator><creator>de las Heras, N</creator><creator>Mateos, M-V</creator><creator>López-Corral, L</creator><creator>Gutiérrez, N C</creator><creator>Blanco, J</creator><creator>Oriol, A</creator><creator>Hernández, M T</creator><creator>de Arriba, F</creator><creator>de Coca, A G</creator><creator>Terol, M-J</creator><creator>de la Rubia, J</creator><creator>González, Y</creator><creator>Martín, A</creator><creator>Sureda, A</creator><creator>Schmidt-Hieber, M</creator><creator>Schmitz, A</creator><creator>Johnsen, H E</creator><creator>Lahuerta, J-J</creator><creator>Bladé, J</creator><creator>San-Miguel, J F</creator><creator>Orfao, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma</title><author>Paiva, B ; 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A</creatorcontrib><creatorcontrib>GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas)</creatorcontrib><creatorcontrib>Myeloma Stem Cell Network (MSCNET)</creatorcontrib><creatorcontrib>on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study groups and the Myeloma Stem Cell Network (MSCNET)</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology 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Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paiva, B</au><au>Pérez-Andrés, M</au><au>Vídriales, M-B</au><au>Almeida, J</au><au>de las Heras, N</au><au>Mateos, M-V</au><au>López-Corral, L</au><au>Gutiérrez, N C</au><au>Blanco, J</au><au>Oriol, A</au><au>Hernández, M T</au><au>de Arriba, F</au><au>de Coca, A G</au><au>Terol, M-J</au><au>de la Rubia, J</au><au>González, Y</au><au>Martín, A</au><au>Sureda, A</au><au>Schmidt-Hieber, M</au><au>Schmitz, A</au><au>Johnsen, H E</au><au>Lahuerta, J-J</au><au>Bladé, J</au><au>San-Miguel, J F</au><au>Orfao, A</au><aucorp>GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas)</aucorp><aucorp>Myeloma Stem Cell Network (MSCNET)</aucorp><aucorp>on behalf of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study groups and the Myeloma Stem Cell Network (MSCNET)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>25</volume><issue>4</issue><spage>697</spage><epage>706</epage><pages>697-706</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Disappearance of normal bone marrow (BM) plasma cells (PC) predicts malignant transformation of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) into symptomatic multiple myeloma (MM). The homing, behavior and survival of normal PC, but also CD34
+
hematopoietic stem cells (HSC), B-cell precursors, and clonal PC largely depends on their interaction with stromal cell-derived factor-1 (SDF-1) expressing, potentially overlapping BM stromal cell niches. Here, we investigate the distribution, phenotypic characteristics and competitive migration capacity of these cell populations in patients with MGUS, SMM and MM vs healthy adults (HA) aged >60 years. Our results show that BM and peripheral blood (PB) clonal PC progressively increase from MGUS to MM, the latter showing a slightly more immature immunophenotype. Of note, such increased number of clonal PC is associated with progressive depletion of normal PC, B-cell precursors and CD34
+
HSC in the BM, also with a parallel increase in PB. In an
ex vivo
model, normal PC, B-cell precursors and CD34
+
HSC from MGUS and SMM, but not MM patients, were able to abrogate the migration of clonal PC into serial concentrations of SDF-1. Overall, our results show that progressive competition and replacement of normal BM cells by clonal PC is associated with more advanced disease in patients with MGUS, SMM and MM.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21252988</pmid><doi>10.1038/leu.2010.320</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2011-04, Vol.25 (4), p.697-706 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_874192052 |
| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | 631/250/1619/40/1742 631/250/1620/1342 692/699/249/1573 692/699/67/1990/804 Adult Aged Aged, 80 and over B-Lymphocytes - cytology B-Lymphocytes - metabolism Benign monoclonal gammopathy Biological and medical sciences Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cancer Research Case-Control Studies CD34 antigen Cell Movement Cells, Cultured Clone Cells Competition Critical Care Medicine Depletion Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Genetic aspects Hematologic and hematopoietic diseases Hematology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Homing behavior Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Immunophenotyping Intensive Internal Medicine Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes B Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple myeloma Multiple Myeloma - metabolism Multiple Myeloma - pathology Oncology original-article Paraproteinemias - metabolism Paraproteinemias - pathology Peripheral blood Physiological aspects Plasma cells Plasma Cells - cytology Plasma Cells - metabolism Precursors Prospective Studies Risk factors SDF-1 protein Smoldering Stem cells |
| title | Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T23%3A38%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Competition%20between%20clonal%20plasma%20cells%20and%20normal%20cells%20for%20potentially%20overlapping%20bone%20marrow%20niches%20is%20associated%20with%20a%20progressively%20altered%20cellular%20distribution%20in%20MGUS%20vs%20myeloma&rft.jtitle=Leukemia&rft.au=Paiva,%20B&rft.aucorp=GEM%20(Grupo%20Espa%C3%B1ol%20de%20MM)/PETHEMA%20(Programa%20para%20el%20Estudio%20de%20la%20Terap%C3%A9utica%20en%20Hemopat%C3%ADas%20Malignas)&rft.date=2011-04-01&rft.volume=25&rft.issue=4&rft.spage=697&rft.epage=706&rft.pages=697-706&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/leu.2010.320&rft_dat=%3Cgale_proqu%3EA254594901%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2645732774&rft_id=info:pmid/21252988&rft_galeid=A254594901&rfr_iscdi=true |