Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1

Chronic lymphocytic leukemia (CLL) has a high prevalence in western countries and remains incurable to date. Here, we provide evidence that the multikinase inhibitor sorafenib induces apoptosis in primary CLL cells. This strong pro-apoptotic effect is not restricted to any subgroup of patients, base...

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Veröffentlicht in:	Leukemia 2011-05, Vol.25 (5), p.838-847
Hauptverfasser:	Huber, S, Oelsner, M, Decker, T, zum Büschenfelde, C Meyer, Wagner, M, Lutzny, G, Kuhnt, T, Schmidt, B, Oostendorp, R A J, Peschel, C, Ringshausen, I
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/82/23 631/92/609 692/699/67/1990/283/1895 Antibodies Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Benzenesulfonates - pharmacology Bevacizumab Biological and medical sciences Cancer Research Caspase-3 CD38 antigen Cell death Chronic lymphocytic leukemia Critical Care Medicine Destabilization Development and progression Diagnosis Drug resistance Drug therapy Epidermal growth factor Flow Cytometry Growth factors Hematologic and hematopoietic diseases Hematology Humans Inhibitor drugs Intensive Internal Medicine Kinases Lck protein Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Mcl-1 protein Medical sciences Medicine Medicine & Public Health Membrane potential Mitochondria Mortality Myeloid Cell Leukemia Sequence 1 Protein Niacinamide - analogs & derivatives Oncology original-article Phenylurea Compounds Phosphorylation Phosphorylation - drug effects Physiological aspects Proto-Oncogene Proteins c-bcl-2 - metabolism Pyridines - pharmacology Receptors, Platelet-Derived Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor - metabolism RNA, Small Interfering - genetics Signal transduction Stromal cells Stromal Cells - metabolism Subgroups Targeted cancer therapy Tumor Cells, Cultured Vascular endothelial growth factor ZAP-70 protein
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