New light labile linker for solid phase synthesis of 2′- O-acetalester oligonucleotides and applications to siRNA prodrug development

A novel light labile linker for RNA synthesis was developed and used in the synthesis of acetalester conjugates. We report on the synthesis and properties of oligonucleotides containing 2′- O-(levulinic acid) and 2′- O-(amino acid) acetalesters. Given that esters serve as promoieties in several ther...

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