Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age

Abstract Streptococcus pneumoniae is a major human pathogen, causing high morbidity and mortality in children, and also in the elderly, who are particularly susceptible to S. pneumoniae infections due to the dysregulated function of the aged immune system. As the current generation of polysaccharide...

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Veröffentlicht in:	Vaccine 2011-05, Vol.29 (23), p.3982-3989
Hauptverfasser:	Schmid, Petra, Selak, Sanja, Keller, Michael, Luhan, Barbara, Magyarics, Zoltan, Seidel, Stefan, Schlick, Petra, Reinisch, Christoph, Lingnau, Karen, Nagy, Eszter, Grubeck-Loebenstein, Beatrix
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Adult Aged Aged, 80 and over Aging - immunology Allergy and Immunology antibodies Antibodies, Bacterial - blood antigens Antigens, Bacterial - immunology Applied microbiology Bacterial Proteins - immunology Bacteriology Biological and medical sciences blood serum cell-mediated immunity children Elderly enzyme-linked immunosorbent assay Fundamental and applied biological sciences. Psychology Human cellular response Humans Immune response Immune system immunoglobulin G interferon-gamma interleukin-17 interleukin-5 Kinases Lipoproteins - immunology Medical research Microbiology Middle Aged middle-aged adults Miscellaneous morbidity mortality Pathogens PcsB people Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Pneumococcus Pneumonia Proteins PsaA secretion StkP Streptococcus pneumoniae Streptococcus pneumoniae - immunology Studies T-lymphocytes Th1 Th1 Cells - immunology Th17 Th17 Cells - immunology Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Young Adult
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