Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study

Striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (DAT). The availability of DAT could be regulated by presynaptic autoreceptors, which are G-protein coupled rece...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2011-06, Vol.56 (3), p.1526-1530
Hauptverfasser:	Chen, Po See, Yeh, Tzung Lieh, Lee, I Hui, Lin, Cheng Bill, Tsai, Hsin Chun, Chen, Kao Chin, Chiu, Nan-Tsing, Yao, Wei Jen, Yang, Yen Kuang, Chou, Yuan-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Body mass index Cognitive ability Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Deoxyribonucleic acid DNA DNA - genetics Dopamine Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Female Gender Gene Frequency Genotype Genotype & phenotype Heterotrimeric GTP-Binding Proteins - genetics Humans Male Medical imaging Organotechnetium Compounds Polymorphism, Genetic - genetics Polymorphism, Single Nucleotide - genetics Proteins Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Second Messenger Systems - genetics Second Messenger Systems - physiology Signal transduction Smoking Smoking - metabolism SPECT Studies Tomography, Emission-Computed, Single-Photon TRODAT-1 Tropanes β3 subunit of G-protein
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