Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study
Striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (DAT). The availability of DAT could be regulated by presynaptic autoreceptors, which are G-protein coupled rece...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2011-06, Vol.56 (3), p.1526-1530 |
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| creator | Chen, Po See Yeh, Tzung Lieh Lee, I Hui Lin, Cheng Bill Tsai, Hsin Chun Chen, Kao Chin Chiu, Nan-Tsing Yao, Wei Jen Yang, Yen Kuang Chou, Yuan-Hwa |
| description | Striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (DAT). The availability of DAT could be regulated by presynaptic autoreceptors, which are G-protein coupled receptors; however, whether functional variations in the common downstream signaling molecule, G-protein, could cause individual differences in presynaptic transporter availability remains unclear. To investigate this relationship, the DAT availability in seventy-eight healthy subjects was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1, a radio-labeled form of tropan derivative for the selective labeling of DAT. The C825T single nucleotide polymorphism (SNP) (rs5443) of the beta subunit of the G-protein second messenger (GNβ3) gene was genotyped, and analysis of variance showed a significant difference in striatal DAT when referenced to the entire occipital lobe among the three genotypes. Post hoc independent t tests were also performed, and showed that the striatal DAT availability of the CC genotype was higher than that of the other two genotypes. These results indicated that genetic variation in the common downstream signaling molecule of the dopamine autoreceptor could affect the functional status of the striatal dopamine system. These results together with the known role of the GNβ3 gene might provide further evidence to support the common effect of the striatal dopamine system on mood and metabolic regulation.
► G-protein variation causes individual dopamine transporter availabilities differences. ► The GNβ3 rs5443 polymorphism affects striatal dopamine transporter availabilities. ► GNβ3 gene may link common effects of dopamine system on mood and metabolic regulation. |
| doi_str_mv | 10.1016/j.neuroimage.2010.10.082 |
| format | Article |
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► G-protein variation causes individual dopamine transporter availabilities differences. ► The GNβ3 rs5443 polymorphism affects striatal dopamine transporter availabilities. ► GNβ3 gene may link common effects of dopamine system on mood and metabolic regulation.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2010.10.082</identifier><identifier>PMID: 21371559</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Alleles ; Body mass index ; Cognitive ability ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - metabolism ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Dopamine ; Dopamine Plasma Membrane Transport Proteins - genetics ; Dopamine Plasma Membrane Transport Proteins - metabolism ; Dopamine transporter ; Female ; Gender ; Gene Frequency ; Genotype ; Genotype & phenotype ; Heterotrimeric GTP-Binding Proteins - genetics ; Humans ; Male ; Medical imaging ; Organotechnetium Compounds ; Polymorphism, Genetic - genetics ; Polymorphism, Single Nucleotide - genetics ; Proteins ; Receptors, Dopamine D2 - genetics ; Receptors, Dopamine D2 - metabolism ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Second Messenger Systems - genetics ; Second Messenger Systems - physiology ; Signal transduction ; Smoking ; Smoking - metabolism ; SPECT ; Studies ; Tomography, Emission-Computed, Single-Photon ; TRODAT-1 ; Tropanes ; β3 subunit of G-protein</subject><ispartof>NeuroImage (Orlando, Fla.), 2011-06, Vol.56 (3), p.1526-1530</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-8c811ac173f3225bc54a1ef434b36ee489fb0ae13ca13de189ff67c61c4de4203</citedby><cites>FETCH-LOGICAL-c499t-8c811ac173f3225bc54a1ef434b36ee489fb0ae13ca13de189ff67c61c4de4203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1668048326?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21371559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Po See</creatorcontrib><creatorcontrib>Yeh, Tzung Lieh</creatorcontrib><creatorcontrib>Lee, I Hui</creatorcontrib><creatorcontrib>Lin, Cheng Bill</creatorcontrib><creatorcontrib>Tsai, Hsin Chun</creatorcontrib><creatorcontrib>Chen, Kao Chin</creatorcontrib><creatorcontrib>Chiu, Nan-Tsing</creatorcontrib><creatorcontrib>Yao, Wei Jen</creatorcontrib><creatorcontrib>Yang, Yen Kuang</creatorcontrib><creatorcontrib>Chou, Yuan-Hwa</creatorcontrib><title>Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (DAT). The availability of DAT could be regulated by presynaptic autoreceptors, which are G-protein coupled receptors; however, whether functional variations in the common downstream signaling molecule, G-protein, could cause individual differences in presynaptic transporter availability remains unclear. To investigate this relationship, the DAT availability in seventy-eight healthy subjects was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1, a radio-labeled form of tropan derivative for the selective labeling of DAT. The C825T single nucleotide polymorphism (SNP) (rs5443) of the beta subunit of the G-protein second messenger (GNβ3) gene was genotyped, and analysis of variance showed a significant difference in striatal DAT when referenced to the entire occipital lobe among the three genotypes. Post hoc independent t tests were also performed, and showed that the striatal DAT availability of the CC genotype was higher than that of the other two genotypes. These results indicated that genetic variation in the common downstream signaling molecule of the dopamine autoreceptor could affect the functional status of the striatal dopamine system. These results together with the known role of the GNβ3 gene might provide further evidence to support the common effect of the striatal dopamine system on mood and metabolic regulation.
► G-protein variation causes individual dopamine transporter availabilities differences. ► The GNβ3 rs5443 polymorphism affects striatal dopamine transporter availabilities. ► GNβ3 gene may link common effects of dopamine system on mood and metabolic regulation.</description><subject>Adult</subject><subject>Alleles</subject><subject>Body mass index</subject><subject>Cognitive ability</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Dopamine</subject><subject>Dopamine Plasma Membrane Transport Proteins - genetics</subject><subject>Dopamine Plasma Membrane Transport Proteins - metabolism</subject><subject>Dopamine transporter</subject><subject>Female</subject><subject>Gender</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Heterotrimeric GTP-Binding Proteins - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Organotechnetium Compounds</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Proteins</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Second Messenger Systems - genetics</subject><subject>Second Messenger Systems - physiology</subject><subject>Signal transduction</subject><subject>Smoking</subject><subject>Smoking - metabolism</subject><subject>SPECT</subject><subject>Studies</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>TRODAT-1</subject><subject>Tropanes</subject><subject>β3 subunit of G-protein</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcFu1DAQQCMEoqXwC8gSB05ZPLGT2Md2tRSkCpBYzpbjTLpeJXGwnZX2gvgIvrBfUoctIHHpyfbMmxmNX5YRoCugUL3br0acvbODvsVVQX-HV1QUT7JzoLLMZVkXT5d7yXIBIM-yFyHsKaUSuHienRXAaihLeZ792HQdmhiI68haFOWWTK4_Ds5POxuGJRp3SK4_XTFyiyMSNxJ90LbXje1tPC5A6yY92JSLXo9hcj6iJ3YkO9R93B3JwfXzGBF9IHc_f5FL8vXLZr0lIc7t8WX2rNN9wFcP50X27f1mu_6Q33y-_ri-vMkNlzLmwqQttIGadawoysaUXAN2nPGGVYhcyK6hGoEZDaxFSO-uqk0FhrfIC8ousrenvpN332cMUQ02GOx7PaKbgxI1B0kZyMfJite1YJQn8s1_5N7NfkxrKKgqQblgRZUocaKMdyF47NTkkzd_VEDVIlPt1T-ZapG5ZJLMVPr6YcDcDNj-LfxjLwFXJwDT1x0sehWMxdFga32SqlpnH59yD0ACtb8</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Chen, Po See</creator><creator>Yeh, Tzung Lieh</creator><creator>Lee, I Hui</creator><creator>Lin, Cheng Bill</creator><creator>Tsai, Hsin Chun</creator><creator>Chen, Kao Chin</creator><creator>Chiu, Nan-Tsing</creator><creator>Yao, Wei Jen</creator><creator>Yang, Yen Kuang</creator><creator>Chou, Yuan-Hwa</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20110601</creationdate><title>Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study</title><author>Chen, Po See ; Yeh, Tzung Lieh ; Lee, I Hui ; Lin, Cheng Bill ; Tsai, Hsin Chun ; Chen, Kao Chin ; Chiu, Nan-Tsing ; Yao, Wei Jen ; Yang, Yen Kuang ; Chou, Yuan-Hwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-8c811ac173f3225bc54a1ef434b36ee489fb0ae13ca13de189ff67c61c4de4203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Body mass index</topic><topic>Cognitive ability</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - metabolism</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>Dopamine</topic><topic>Dopamine Plasma Membrane Transport Proteins - genetics</topic><topic>Dopamine Plasma Membrane Transport Proteins - metabolism</topic><topic>Dopamine transporter</topic><topic>Female</topic><topic>Gender</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Heterotrimeric GTP-Binding Proteins - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Organotechnetium Compounds</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Proteins</topic><topic>Receptors, Dopamine D2 - genetics</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Second Messenger Systems - genetics</topic><topic>Second Messenger Systems - physiology</topic><topic>Signal transduction</topic><topic>Smoking</topic><topic>Smoking - metabolism</topic><topic>SPECT</topic><topic>Studies</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>TRODAT-1</topic><topic>Tropanes</topic><topic>β3 subunit of G-protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Po See</creatorcontrib><creatorcontrib>Yeh, Tzung Lieh</creatorcontrib><creatorcontrib>Lee, I Hui</creatorcontrib><creatorcontrib>Lin, Cheng Bill</creatorcontrib><creatorcontrib>Tsai, Hsin Chun</creatorcontrib><creatorcontrib>Chen, Kao Chin</creatorcontrib><creatorcontrib>Chiu, Nan-Tsing</creatorcontrib><creatorcontrib>Yao, Wei Jen</creatorcontrib><creatorcontrib>Yang, Yen Kuang</creatorcontrib><creatorcontrib>Chou, Yuan-Hwa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Po See</au><au>Yeh, Tzung Lieh</au><au>Lee, I Hui</au><au>Lin, Cheng Bill</au><au>Tsai, Hsin Chun</au><au>Chen, Kao Chin</au><au>Chiu, Nan-Tsing</au><au>Yao, Wei Jen</au><au>Yang, Yen Kuang</au><au>Chou, Yuan-Hwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>56</volume><issue>3</issue><spage>1526</spage><epage>1530</epage><pages>1526-1530</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (DAT). The availability of DAT could be regulated by presynaptic autoreceptors, which are G-protein coupled receptors; however, whether functional variations in the common downstream signaling molecule, G-protein, could cause individual differences in presynaptic transporter availability remains unclear. To investigate this relationship, the DAT availability in seventy-eight healthy subjects was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1, a radio-labeled form of tropan derivative for the selective labeling of DAT. The C825T single nucleotide polymorphism (SNP) (rs5443) of the beta subunit of the G-protein second messenger (GNβ3) gene was genotyped, and analysis of variance showed a significant difference in striatal DAT when referenced to the entire occipital lobe among the three genotypes. Post hoc independent t tests were also performed, and showed that the striatal DAT availability of the CC genotype was higher than that of the other two genotypes. These results indicated that genetic variation in the common downstream signaling molecule of the dopamine autoreceptor could affect the functional status of the striatal dopamine system. These results together with the known role of the GNβ3 gene might provide further evidence to support the common effect of the striatal dopamine system on mood and metabolic regulation.
► G-protein variation causes individual dopamine transporter availabilities differences. ► The GNβ3 rs5443 polymorphism affects striatal dopamine transporter availabilities. ► GNβ3 gene may link common effects of dopamine system on mood and metabolic regulation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21371559</pmid><doi>10.1016/j.neuroimage.2010.10.082</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Alleles Body mass index Cognitive ability Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Deoxyribonucleic acid DNA DNA - genetics Dopamine Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Female Gender Gene Frequency Genotype Genotype & phenotype Heterotrimeric GTP-Binding Proteins - genetics Humans Male Medical imaging Organotechnetium Compounds Polymorphism, Genetic - genetics Polymorphism, Single Nucleotide - genetics Proteins Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Second Messenger Systems - genetics Second Messenger Systems - physiology Signal transduction Smoking Smoking - metabolism SPECT Studies Tomography, Emission-Computed, Single-Photon TRODAT-1 Tropanes β3 subunit of G-protein |
| title | Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study |
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