Subcutaneous and intranasal immunization with Stx2B–Tir–Stx1B–Zot reduces colonization and shedding of Escherichia coli O157:H7 in mice

Abstract The type III secretion system of Escherichia coli O157:H7 is involved in colonization of mammalian hosts by the organism. The translocated intimin receptor (Tir) is inserted into the mammalian host cell plasma membrane in a hairpin loop topology with the central loop of the molecule exposed...

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Veröffentlicht in:	Vaccine 2011-05, Vol.29 (22), p.3923-3929
Hauptverfasser:	Zhang, Xue-han, He, Kong-wang, Zhang, Shu-xia, Lu, Wei-cai, Zhao, Pan-deng, Luan, Xiao-ting, Ye, Qing, Wen, Li-bin, Li, Bin, Guo, Rong-li, Wang, Xiao-min, Lv, Li-xin, Zhou, Jun-ming, Yu, Zheng-yu, Mao, Ai-hua
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesins Administration, Intranasal Allergy and Immunology animal models Animals antibodies antigens Applied microbiology Bacterial Shedding - immunology Bacteriology bacteriophages Biological and medical sciences blood serum Cholera Toxin - genetics Cholera Toxin - immunology chromatography Escherichia coli Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Escherichia coli O157 Escherichia coli O157 - growth & development Escherichia coli O157 - pathogenicity Escherichia coli Proteins - genetics Escherichia coli Proteins - immunology Escherichia coli Vaccines - administration & dosage Escherichia coli Vaccines - genetics Escherichia coli Vaccines - immunology feces Fundamental and applied biological sciences. Psychology hemolytic uremic syndrome hosts immune response immunization immunoglobulin A immunoglobulin G Injections, Subcutaneous intestinal mucosa intimin intranasal administration Male Mice Mice, Inbred BALB C Microbiology Miscellaneous O157:H7 permeability plasma membrane polypeptides Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Shiga toxin Shiga Toxin 1 - genetics Shiga Toxin 1 - immunology Shiga Toxin 2 - genetics Shiga Toxin 2 - immunology Shiga-like toxin 1 tight junctions topology Translocated intimin receptor Type III secretion system Vaccine vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vibrio cholerae Zot
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