Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase
Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer’s disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl c...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (13), p.3997-4000 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Suresh Kumar, Raju Ashraf Ali, Mohamed Osman, Hasnah Ismail, Rusli Choon, Tan Soo Yoon, Yeong Keng Wei, Ang Chee Pandian, Suresh Manogaran, Elumalai |
| description | Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer’s disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC₅₀ 0.72μmol/L. |
| doi_str_mv | 10.1016/j.bmcl.2011.05.003 |
| format | Article |
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The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC₅₀ 0.72μmol/L.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2011.05.003</identifier><identifier>PMID: 21621414</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>acetylcholinesterase ; Acetylcholinesterase - chemistry ; Alzheimer disease ; Biological and medical sciences ; cholinesterase ; Cholinesterase Inhibitors - chemical synthesis ; Cholinesterase Inhibitors - chemistry ; Cholinesterase Inhibitors - pharmacology ; Drug Discovery ; Heterocyclic Compounds, 4 or More Rings - chemical synthesis ; Heterocyclic Compounds, 4 or More Rings - chemistry ; Heterocyclic Compounds, 4 or More Rings - pharmacology ; Humans ; Inhibitory Concentration 50 ; Medical sciences ; Molecular Structure ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology</subject><ispartof>Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3997-4000</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. 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The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC₅₀ 0.72μmol/L.</description><subject>acetylcholinesterase</subject><subject>Acetylcholinesterase - chemistry</subject><subject>Alzheimer disease</subject><subject>Biological and medical sciences</subject><subject>cholinesterase</subject><subject>Cholinesterase Inhibitors - chemical synthesis</subject><subject>Cholinesterase Inhibitors - chemistry</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Drug Discovery</subject><subject>Heterocyclic Compounds, 4 or More Rings - chemical synthesis</subject><subject>Heterocyclic Compounds, 4 or More Rings - chemistry</subject><subject>Heterocyclic Compounds, 4 or More Rings - pharmacology</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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| subjects | acetylcholinesterase Acetylcholinesterase - chemistry Alzheimer disease Biological and medical sciences cholinesterase Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Drug Discovery Heterocyclic Compounds, 4 or More Rings - chemical synthesis Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Inhibitory Concentration 50 Medical sciences Molecular Structure Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology |
| title | Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase |
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