Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells

► FoxO1 and FoxO3a had a significant kinetic difference in nuclear export processes. ► FoxO3a was more sensitive than FoxO1 to NGF treatment. ► NGF had no effect on FoxO6s nuclear localization. Nuclear translocation of Forkhead transcription factors of the O class (FoxOs) is important for the action...

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Veröffentlicht in:	Neuroscience letters 2011-07, Vol.498 (1), p.31-36
Hauptverfasser:	Wen, Qiang, Duan, Xiaolu, Liao, Rifang, Little, Peter, Gao, Guoquan, Jiang, Hao, Lalit, Srivastava, Quirion, Remi, Zheng, Wenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cell Nucleus - chemistry Cell Nucleus - metabolism Cytoplasm - chemistry Cytoplasm - metabolism Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism FoxO1 FoxO3a Fundamental and applied biological sciences. Psychology Intracellular Space - metabolism Kinetics Nerve Growth Factor - metabolism Nerve Tissue Proteins - metabolism NGF PC12 Cells PI3-K/Akt Protein Transport - physiology Rats Vertebrates: nervous system and sense organs
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