Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites
The reproductive and developmental toxicities of caffeine (CA) reported in mammals have been linked with the characteristics of its kinetic disposition. Because undesirable reproductive effects in fish have also been reported, and considering that CA has been found worldwide at relatively high conce...
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| description | The reproductive and developmental toxicities of caffeine (CA) reported in mammals have been linked with the characteristics of its kinetic disposition. Because undesirable reproductive effects in fish have also been reported, and considering that CA has been found worldwide at relatively high concentrations in most bodies of waters, this study evaluated the disposition kinetics of CA and its main metabolite paraxanthine (1,7-dimethylxanthine; PX) in Nile tilapia after a single intraperitoneal administration (4 mg/kg). CA showed rapid absorption, first-order elimination with biexponential decay, rapid intercompartmental transfer, wide distribution in almost the entire body water (apparent volume of distribution [Vd
ss
] 0.45 l/kg), terminal elimination half-life (t
1/2
β
) 4.08 h, and systemic clearance (Cl) 0.75 ml/min/kg; there were no important differences between parameters determined in plasma or in other organs (liver and gills). PX was rapidly formed in liver, showing saturable-kinetic properties in this organ, with V
max
8.11 μg/g h and K
m
12.58 μg/g. The terminal elimination linear process was similar between matrices, with a half-life (t
1/2 el
) 2.12 h, Vd
ss
0.35 l/kg, and Cl 1.24 ml/min/kg. CA in tilapia was extensively metabolized to 1-methyl-uric acid and 1-methyl-xanthine in all of the organs studied. Metabolic and kinetic patterns were comparable with those reported for mammals. The observation of a concentration-dependent kinetic of PX is an important finding. Thus, toxicities of CA in fish would appear to be similar to those in mammals and should be considered in the risk assessments for this species, especially during the early stages of development. |
| doi_str_mv | 10.1007/s00244-010-9571-9 |
| format | Article |
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ss
] 0.45 l/kg), terminal elimination half-life (t
1/2
β
) 4.08 h, and systemic clearance (Cl) 0.75 ml/min/kg; there were no important differences between parameters determined in plasma or in other organs (liver and gills). PX was rapidly formed in liver, showing saturable-kinetic properties in this organ, with V
max
8.11 μg/g h and K
m
12.58 μg/g. The terminal elimination linear process was similar between matrices, with a half-life (t
1/2 el
) 2.12 h, Vd
ss
0.35 l/kg, and Cl 1.24 ml/min/kg. CA in tilapia was extensively metabolized to 1-methyl-uric acid and 1-methyl-xanthine in all of the organs studied. Metabolic and kinetic patterns were comparable with those reported for mammals. The observation of a concentration-dependent kinetic of PX is an important finding. Thus, toxicities of CA in fish would appear to be similar to those in mammals and should be considered in the risk assessments for this species, especially during the early stages of development.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-010-9571-9</identifier><identifier>PMID: 20669017</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Acids ; Analysis ; Animal and plant ecology ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Brackish ; Caffeine ; Caffeine - blood ; Caffeine - pharmacokinetics ; Chromatography, High Pressure Liquid ; Cichlids - blood ; Cichlids - metabolism ; Developmental stages ; Earth and Environmental Science ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Environment ; Environmental Chemistry ; Environmental Health ; Fish ; Fresh water ecosystems ; Fundamental and applied biological sciences. Psychology ; General aspects ; Kinetics ; Male ; Mammals ; Metabolism ; Metabolites ; Monitoring/Environmental Analysis ; Oreochromis niloticus ; Organs ; Pollution ; Pregnancy ; Risk assessment ; Soil Science & Conservation ; Studies ; Synecology ; Terminals ; Theophylline - blood ; Theophylline - pharmacokinetics ; Tilapia ; Tissue Distribution ; Toxicity ; Water Pollutants, Chemical - pharmacokinetics</subject><ispartof>Archives of environmental contamination and toxicology, 2011-05, Vol.60 (4), p.654-664</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-19932728e5bb8976e1beacb44091199db10b76144671b790aa20568b092b03643</citedby><cites>FETCH-LOGICAL-c465t-19932728e5bb8976e1beacb44091199db10b76144671b790aa20568b092b03643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00244-010-9571-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00244-010-9571-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24154577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20669017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez-Martínez, Lisbeth E.</creatorcontrib><title>Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><addtitle>Arch Environ Contam Toxicol</addtitle><description>The reproductive and developmental toxicities of caffeine (CA) reported in mammals have been linked with the characteristics of its kinetic disposition. Because undesirable reproductive effects in fish have also been reported, and considering that CA has been found worldwide at relatively high concentrations in most bodies of waters, this study evaluated the disposition kinetics of CA and its main metabolite paraxanthine (1,7-dimethylxanthine; PX) in Nile tilapia after a single intraperitoneal administration (4 mg/kg). CA showed rapid absorption, first-order elimination with biexponential decay, rapid intercompartmental transfer, wide distribution in almost the entire body water (apparent volume of distribution [Vd
ss
] 0.45 l/kg), terminal elimination half-life (t
1/2
β
) 4.08 h, and systemic clearance (Cl) 0.75 ml/min/kg; there were no important differences between parameters determined in plasma or in other organs (liver and gills). PX was rapidly formed in liver, showing saturable-kinetic properties in this organ, with V
max
8.11 μg/g h and K
m
12.58 μg/g. The terminal elimination linear process was similar between matrices, with a half-life (t
1/2 el
) 2.12 h, Vd
ss
0.35 l/kg, and Cl 1.24 ml/min/kg. CA in tilapia was extensively metabolized to 1-methyl-uric acid and 1-methyl-xanthine in all of the organs studied. Metabolic and kinetic patterns were comparable with those reported for mammals. The observation of a concentration-dependent kinetic of PX is an important finding. Thus, toxicities of CA in fish would appear to be similar to those in mammals and should be considered in the risk assessments for this species, especially during the early stages of development.</description><subject>Acids</subject><subject>Analysis</subject><subject>Animal and plant ecology</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Brackish</subject><subject>Caffeine</subject><subject>Caffeine - blood</subject><subject>Caffeine - pharmacokinetics</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cichlids - blood</subject><subject>Cichlids - metabolism</subject><subject>Developmental stages</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Fish</subject><subject>Fresh water ecosystems</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Kinetics</subject><subject>Male</subject><subject>Mammals</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Monitoring/Environmental Analysis</subject><subject>Oreochromis niloticus</subject><subject>Organs</subject><subject>Pollution</subject><subject>Pregnancy</subject><subject>Risk assessment</subject><subject>Soil Science & Conservation</subject><subject>Studies</subject><subject>Synecology</subject><subject>Terminals</subject><subject>Theophylline - blood</subject><subject>Theophylline - pharmacokinetics</subject><subject>Tilapia</subject><subject>Tissue Distribution</subject><subject>Toxicity</subject><subject>Water Pollutants, Chemical - pharmacokinetics</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFu1DAQhi0EotvCA3BBFhKiHAIzjmPH3NACLaKlHMrZsrMO6yprL3YiUa68OE53aSUkOFn2fPPNWD8hTxBeIYB8nQEY5xUgVKqRWKl7ZIG8ZhVIqO-TBYCCitccD8hhzlcAyNqWPyQHDIRQgHJBfr3zeRuzH30M9JMPbvRdprGnS9P3rtypCSv6xSTzw4RxPT_4QD_7wdFLP5itN_T4IrnYrVPc-EyDH2JRTPnlG7pcl7ZudMn_NDf-oh3Xjp6bojh3o7Fx8KPLj8iD3gzZPd6fR-Trh_eXy9Pq7OLk4_LtWdVx0YwVKlUzyVrXWNsqKRxaZzrLOSgstZVFsFIg50KilQqMYdCI1oJiFmrB6yPyYufdpvh9cnnUZePODYMJLk5Zt5Jjq4qukMf_JVEKhgzqWhT02V_oVZxSKP_QrSghgYC2QLiDuhRzTq7X2-Q3Jl1rBD1HqXdR6hKlnqPU8w5P9-LJbtzqtuNPdgV4vgdM7szQJxM6n-84jg1v5MyxHZdLKXxz6W7Df0__DTqStMA</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Gómez-Martínez, Lisbeth E.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7SU</scope><scope>KR7</scope><scope>7QH</scope><scope>7ST</scope><scope>7T2</scope><scope>7U2</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>20110501</creationdate><title>Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites</title><author>Gómez-Martínez, Lisbeth E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-19932728e5bb8976e1beacb44091199db10b76144671b790aa20568b092b03643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>Animal and plant ecology</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Brackish</topic><topic>Caffeine</topic><topic>Caffeine - blood</topic><topic>Caffeine - pharmacokinetics</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cichlids - blood</topic><topic>Cichlids - metabolism</topic><topic>Developmental stages</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Fish</topic><topic>Fresh water ecosystems</topic><topic>Fundamental and applied biological sciences. 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez-Martínez, Lisbeth E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><stitle>Arch Environ Contam Toxicol</stitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>60</volume><issue>4</issue><spage>654</spage><epage>664</epage><pages>654-664</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>The reproductive and developmental toxicities of caffeine (CA) reported in mammals have been linked with the characteristics of its kinetic disposition. Because undesirable reproductive effects in fish have also been reported, and considering that CA has been found worldwide at relatively high concentrations in most bodies of waters, this study evaluated the disposition kinetics of CA and its main metabolite paraxanthine (1,7-dimethylxanthine; PX) in Nile tilapia after a single intraperitoneal administration (4 mg/kg). CA showed rapid absorption, first-order elimination with biexponential decay, rapid intercompartmental transfer, wide distribution in almost the entire body water (apparent volume of distribution [Vd
ss
] 0.45 l/kg), terminal elimination half-life (t
1/2
β
) 4.08 h, and systemic clearance (Cl) 0.75 ml/min/kg; there were no important differences between parameters determined in plasma or in other organs (liver and gills). PX was rapidly formed in liver, showing saturable-kinetic properties in this organ, with V
max
8.11 μg/g h and K
m
12.58 μg/g. The terminal elimination linear process was similar between matrices, with a half-life (t
1/2 el
) 2.12 h, Vd
ss
0.35 l/kg, and Cl 1.24 ml/min/kg. CA in tilapia was extensively metabolized to 1-methyl-uric acid and 1-methyl-xanthine in all of the organs studied. Metabolic and kinetic patterns were comparable with those reported for mammals. The observation of a concentration-dependent kinetic of PX is an important finding. Thus, toxicities of CA in fish would appear to be similar to those in mammals and should be considered in the risk assessments for this species, especially during the early stages of development.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20669017</pmid><doi>10.1007/s00244-010-9571-9</doi><tpages>11</tpages></addata></record> |
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| ispartof | Archives of environmental contamination and toxicology, 2011-05, Vol.60 (4), p.654-664 |
| issn | 0090-4341 1432-0703 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_874189409 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acids Analysis Animal and plant ecology Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Brackish Caffeine Caffeine - blood Caffeine - pharmacokinetics Chromatography, High Pressure Liquid Cichlids - blood Cichlids - metabolism Developmental stages Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Environment Environmental Chemistry Environmental Health Fish Fresh water ecosystems Fundamental and applied biological sciences. Psychology General aspects Kinetics Male Mammals Metabolism Metabolites Monitoring/Environmental Analysis Oreochromis niloticus Organs Pollution Pregnancy Risk assessment Soil Science & Conservation Studies Synecology Terminals Theophylline - blood Theophylline - pharmacokinetics Tilapia Tissue Distribution Toxicity Water Pollutants, Chemical - pharmacokinetics |
| title | Disposition Kinetics of Caffeine and Paraxanthine in Nile Tilapia (Oreochromis niloticus): Characterization of the Main Metabolites |
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