Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population
► PITX3 is a good candidate gene for Parkinson's disease (PD). ► Three PITX3 SNPs are reported to be associated with PD. ► The associations of these three PITX3 SNPs with PD were examined in Chinese. ► Allele and genotype frequencies did not differ between patients and controls. PITX3 is a tran...
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| Veröffentlicht in: | Neuroscience letters 2011-07, Vol.498 (2), p.124-126 |
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| creator | Cai, Yanning Ding, Hui Gu, Zhuqin Ma, Jinghong Chan, Piu |
| description | ►
PITX3 is a good candidate gene for Parkinson's disease (PD). ► Three
PITX3 SNPs are reported to be associated with PD. ► The associations of these three
PITX3 SNPs with PD were examined in Chinese. ► Allele and genotype frequencies did not differ between patients and controls.
PITX3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for Parkinson's disease (PD). Recent association studies indicated that three
PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD. However, no similar associations in Chinese populations have been reported. To examine the nature of the association in Chinese individuals we analyzed DNA samples for these three
PITX3 SNPs from 509 late-onset sporadic PD patients, and 494 healthy controls, using a ligase detection reaction (LDR). Results indicated that allele and genotype frequencies did not differ between patients and controls for all three SNPs, suggesting that these SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population. |
| doi_str_mv | 10.1016/j.neulet.2011.04.073 |
| format | Article |
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PITX3 is a good candidate gene for Parkinson's disease (PD). ► Three
PITX3 SNPs are reported to be associated with PD. ► The associations of these three
PITX3 SNPs with PD were examined in Chinese. ► Allele and genotype frequencies did not differ between patients and controls.
PITX3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for Parkinson's disease (PD). Recent association studies indicated that three
PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD. However, no similar associations in Chinese populations have been reported. To examine the nature of the association in Chinese individuals we analyzed DNA samples for these three
PITX3 SNPs from 509 late-onset sporadic PD patients, and 494 healthy controls, using a ligase detection reaction (LDR). Results indicated that allele and genotype frequencies did not differ between patients and controls for all three SNPs, suggesting that these SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2011.04.073</identifier><identifier>PMID: 21565251</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age of Onset ; Aged ; Alleles ; Biological and medical sciences ; Case–control study ; China - epidemiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genotype ; Homeodomain Proteins - genetics ; Homeodomain Proteins - physiology ; Humans ; Ligase Chain Reaction ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parkinson Disease - epidemiology ; Parkinson Disease - genetics ; Parkinson's disease ; PITX3 ; Polymorphism, Single Nucleotide ; Single nucleotide polymorphism ; Transcription Factors - genetics ; Transcription Factors - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2011-07, Vol.498 (2), p.124-126</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-8f46daa176fef1023187627d36922f8233743e2838165fa0604c790bb19a1d843</citedby><cites>FETCH-LOGICAL-c423t-8f46daa176fef1023187627d36922f8233743e2838165fa0604c790bb19a1d843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439401100557X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24266735$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21565251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Yanning</creatorcontrib><creatorcontrib>Ding, Hui</creatorcontrib><creatorcontrib>Gu, Zhuqin</creatorcontrib><creatorcontrib>Ma, Jinghong</creatorcontrib><creatorcontrib>Chan, Piu</creatorcontrib><title>Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>►
PITX3 is a good candidate gene for Parkinson's disease (PD). ► Three
PITX3 SNPs are reported to be associated with PD. ► The associations of these three
PITX3 SNPs with PD were examined in Chinese. ► Allele and genotype frequencies did not differ between patients and controls.
PITX3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for Parkinson's disease (PD). Recent association studies indicated that three
PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD. However, no similar associations in Chinese populations have been reported. To examine the nature of the association in Chinese individuals we analyzed DNA samples for these three
PITX3 SNPs from 509 late-onset sporadic PD patients, and 494 healthy controls, using a ligase detection reaction (LDR). Results indicated that allele and genotype frequencies did not differ between patients and controls for all three SNPs, suggesting that these SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population.</description><subject>Age of Onset</subject><subject>Aged</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Case–control study</subject><subject>China - epidemiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - physiology</subject><subject>Humans</subject><subject>Ligase Chain Reaction</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>PITX3</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Single nucleotide polymorphism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EokvhGyDkC-opwf_iJBcktIK2UiV6KBI3y-tMWC9ZO3icVvDp8Wq3cIOTx_LvvfHMI-Q1ZzVnXL_b1QGWCXItGOc1UzVr5ROy4l0rqrZvxVOyYpKpSvaKnZEXiDvGWMMb9ZycCd7oRjR8RX5dQoDsHb23yduQkcaR5i3Q2-u7r5J-K6_UJqAhZmoRo_M2w0AffN7SqZRVDAiZ4hyTHYrNrU3ffcAYLpAOHsEiUB-opeutD1Auc5yXIvQxvCTPRjshvDqd5-TLp49366vq5vPl9frDTeWUkLnqRqUHa3mrRxg5E7JMqEU7SN0LMXZCylZJEJ3suG5GyzRTru3ZZsN7y4dOyXNycfSdU_yxAGaz9-hgmmyAuKDpWsW7XpT1_Z8UjeS6awqpjqRLETHBaObk9zb9NJyZQzxmZ47xmEM8hilT_IvszanBstnD8Ef0mEcB3p4Ai85OY7LBefzLKaF1Kw_93x85KIu795AMOg_BweATuGyG6P_9k99k_a7e</recordid><startdate>20110708</startdate><enddate>20110708</enddate><creator>Cai, Yanning</creator><creator>Ding, Hui</creator><creator>Gu, Zhuqin</creator><creator>Ma, Jinghong</creator><creator>Chan, Piu</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110708</creationdate><title>Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population</title><author>Cai, Yanning ; Ding, Hui ; Gu, Zhuqin ; Ma, Jinghong ; Chan, Piu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-8f46daa176fef1023187627d36922f8233743e2838165fa0604c790bb19a1d843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age of Onset</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Case–control study</topic><topic>China - epidemiology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - physiology</topic><topic>Humans</topic><topic>Ligase Chain Reaction</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson's disease</topic><topic>PITX3</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Single nucleotide polymorphism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Yanning</creatorcontrib><creatorcontrib>Ding, Hui</creatorcontrib><creatorcontrib>Gu, Zhuqin</creatorcontrib><creatorcontrib>Ma, Jinghong</creatorcontrib><creatorcontrib>Chan, Piu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Yanning</au><au>Ding, Hui</au><au>Gu, Zhuqin</au><au>Ma, Jinghong</au><au>Chan, Piu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2011-07-08</date><risdate>2011</risdate><volume>498</volume><issue>2</issue><spage>124</spage><epage>126</epage><pages>124-126</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>►
PITX3 is a good candidate gene for Parkinson's disease (PD). ► Three
PITX3 SNPs are reported to be associated with PD. ► The associations of these three
PITX3 SNPs with PD were examined in Chinese. ► Allele and genotype frequencies did not differ between patients and controls.
PITX3 is a transcription factor which determines the survival of dopaminergic neurons in the substantia nigra, and is considered a candidate gene for Parkinson's disease (PD). Recent association studies indicated that three
PITX3 single nucleotide polymorphisms (SNPs), including rs2281983, rs4919621, and rs3758549 are likely to be associated with PD. However, no similar associations in Chinese populations have been reported. To examine the nature of the association in Chinese individuals we analyzed DNA samples for these three
PITX3 SNPs from 509 late-onset sporadic PD patients, and 494 healthy controls, using a ligase detection reaction (LDR). Results indicated that allele and genotype frequencies did not differ between patients and controls for all three SNPs, suggesting that these SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21565251</pmid><doi>10.1016/j.neulet.2011.04.073</doi><tpages>3</tpages></addata></record> |
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| subjects | Age of Onset Aged Alleles Biological and medical sciences Case–control study China - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Fundamental and applied biological sciences. Psychology Gene Frequency Genotype Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans Ligase Chain Reaction Male Medical sciences Middle Aged Neurology Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease PITX3 Polymorphism, Single Nucleotide Single nucleotide polymorphism Transcription Factors - genetics Transcription Factors - physiology Vertebrates: nervous system and sense organs |
| title | Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population |
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