Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection

Abstract Human enterovirus 71 (HEV71) has emerged as a major cause of epidemics of hand, foot and mouth disease associated with severe neurological sequelae in the Asia-Pacific region. In this study, a passive protection mouse model was used to evaluate the protective efficacy of formalin-inactivate...

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Veröffentlicht in:	Vaccine 2011-06, Vol.29 (29), p.4829-4838
Hauptverfasser:	Bek, Emily Jane, Hussain, Khairunnisa Mohamed, Phuektes, Patchara, Kok, Chee Choy, Gao, Qiang, Cai, Fang, Gao, Zhenglun, McMinn, Peter Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Applied microbiology Biological and medical sciences Cross Protection Disease Models, Animal Encephalitis Enterovirus A, Human - immunology Enterovirus Infections - prevention & control Female Formaldehyde Fundamental and applied biological sciences. Psychology Genotype & phenotype Human enterovirus 71 Immunization Immunization, Secondary - methods Inactivated vaccine Infections Mice Mice, Inbred BALB C Microbiology Miscellaneous Pregnancy Rodent Diseases - prevention & control Rodent Diseases - virology Rodents Survival Analysis Vaccination - methods Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology Viral Load Viral Vaccines - administration & dosage Viral Vaccines - immunology Virology Viruses
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