Mechanical Properties of Achilles Tendon in Rats Induced to Experimental Diabetes
The aim of this study was to quantify the effect of chemically induced diabetes mellitus (DM) on the mechanical properties of the Achilles tendon of rats and correlate it with metabolic and biomechanical findings. Adult rats were selected randomly and assigned to two groups, the diabetic group consi...
Gespeichert in:
| Veröffentlicht in: | Annals of biomedical engineering 2011-05, Vol.39 (5), p.1528-1534 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1534 |
|---|---|
| container_issue | 5 |
| container_start_page | 1528 |
| container_title | Annals of biomedical engineering |
| container_volume | 39 |
| creator | de Oliveira, Rodrigo Ribeiro de Lira, Kamilla Dinah Santos de Castro Silveira, Patrícia Verçoza Coutinho, Marcos Paulo Galdino Medeiros, Marcela Nicácio Teixeira, Magno Felipe Holanda Barboza Inácio de Moraes, Silvia Regina Arruda |
| description | The aim of this study was to quantify the effect of chemically induced diabetes mellitus (DM) on the mechanical properties of the Achilles tendon of rats and correlate it with metabolic and biomechanical findings. Adult rats were selected randomly and assigned to two groups, the diabetic group consisted of animals receiving a dose of streptozotocin to induce type I diabetes and the control group. The animals were placed in metabolic cages for analysis of metabolism. Ten weeks after diabetes induction, the Achilles tendon of both groups were collected and submitted to a traction test in a conventional testing machine. The measurements of mechanical properties indicated that the elastic modulus (MPa) was significantly higher in the control group (
p
0.01). Energy/tendon area (N mm/mm
2
), specific strain (%) and maximum specific strain (mm) were higher in tendon tests of the diabetic group (
p
|
| doi_str_mv | 10.1007/s10439-011-0247-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_874188231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>874188231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-89e160e9bfbf63ae428cd1a82840b743607e2f8ed8291409eebe91425595f7463</originalsourceid><addsrcrecordid>eNqFkU1P3DAQhq0KBMvHD-gFRVx6SpmxHX8cV5QCEqgFwdlykknJKusscSK1--vxamkrISFOM9I87zuaeRn7jPAVAfRZRJDC5oCYA5c6X39iMyy0yK0yaofNACzkyiq5zw5iXEACjSj22D5Hzgsh5Yzd3VL15ENb-S77OfQrGsaWYtY32bx6arsu9Q8U6j5kbcju_Riz61BPFdXZ2GcXvxPfLimMSf2t9SWNFI_YbuO7SMev9ZA9fr94OL_Kb35cXp_Pb_JKAh9zYwkVkC2bslHCk-SmqtEbbiSUWgoFmnhjqDbcogRLVFJqeFHYotFSiUP2Zeu7GvrnieLolm2sqOt8oH6KzmiJxnCBH5MKOUhAmcjTN-Sin4aQzkgQCI1KFwnCLVQNfYwDNW6VnuCHPw7BbXJx21xcerfb5OLWSXPyajyVS6r_Kf4GkQC-BWIahV80_N_8vusL6ICWwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>860371675</pqid></control><display><type>article</type><title>Mechanical Properties of Achilles Tendon in Rats Induced to Experimental Diabetes</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>de Oliveira, Rodrigo Ribeiro ; de Lira, Kamilla Dinah Santos ; de Castro Silveira, Patrícia Verçoza ; Coutinho, Marcos Paulo Galdino ; Medeiros, Marcela Nicácio ; Teixeira, Magno Felipe Holanda Barboza Inácio ; de Moraes, Silvia Regina Arruda</creator><creatorcontrib>de Oliveira, Rodrigo Ribeiro ; de Lira, Kamilla Dinah Santos ; de Castro Silveira, Patrícia Verçoza ; Coutinho, Marcos Paulo Galdino ; Medeiros, Marcela Nicácio ; Teixeira, Magno Felipe Holanda Barboza Inácio ; de Moraes, Silvia Regina Arruda</creatorcontrib><description>The aim of this study was to quantify the effect of chemically induced diabetes mellitus (DM) on the mechanical properties of the Achilles tendon of rats and correlate it with metabolic and biomechanical findings. Adult rats were selected randomly and assigned to two groups, the diabetic group consisted of animals receiving a dose of streptozotocin to induce type I diabetes and the control group. The animals were placed in metabolic cages for analysis of metabolism. Ten weeks after diabetes induction, the Achilles tendon of both groups were collected and submitted to a traction test in a conventional testing machine. The measurements of mechanical properties indicated that the elastic modulus (MPa) was significantly higher in the control group (
p
< 0.01). In Maximum tension (MPa), the groups did not have differences (
p
> 0.01). Energy/tendon area (N mm/mm
2
), specific strain (%) and maximum specific strain (mm) were higher in tendon tests of the diabetic group (
p
< 0.01). We observed that the mechanical properties of tendons have correlations with metabolic properties of the diabetic animals. These results showed that induced DM in rats have an important negative effect on the mechanical properties of the Achilles tendon.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-011-0247-z</identifier><identifier>PMID: 21225344</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Achilles Tendon - metabolism ; Achilles Tendon - pathology ; Achilles Tendon - physiopathology ; Animals ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Classical Mechanics ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Experimental - physiopathology ; Elasticity ; Humans ; Male ; Models, Biological ; Rats ; Rats, Wistar</subject><ispartof>Annals of biomedical engineering, 2011-05, Vol.39 (5), p.1528-1534</ispartof><rights>Biomedical Engineering Society 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-89e160e9bfbf63ae428cd1a82840b743607e2f8ed8291409eebe91425595f7463</citedby><cites>FETCH-LOGICAL-c402t-89e160e9bfbf63ae428cd1a82840b743607e2f8ed8291409eebe91425595f7463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-011-0247-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-011-0247-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21225344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira, Rodrigo Ribeiro</creatorcontrib><creatorcontrib>de Lira, Kamilla Dinah Santos</creatorcontrib><creatorcontrib>de Castro Silveira, Patrícia Verçoza</creatorcontrib><creatorcontrib>Coutinho, Marcos Paulo Galdino</creatorcontrib><creatorcontrib>Medeiros, Marcela Nicácio</creatorcontrib><creatorcontrib>Teixeira, Magno Felipe Holanda Barboza Inácio</creatorcontrib><creatorcontrib>de Moraes, Silvia Regina Arruda</creatorcontrib><title>Mechanical Properties of Achilles Tendon in Rats Induced to Experimental Diabetes</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>The aim of this study was to quantify the effect of chemically induced diabetes mellitus (DM) on the mechanical properties of the Achilles tendon of rats and correlate it with metabolic and biomechanical findings. Adult rats were selected randomly and assigned to two groups, the diabetic group consisted of animals receiving a dose of streptozotocin to induce type I diabetes and the control group. The animals were placed in metabolic cages for analysis of metabolism. Ten weeks after diabetes induction, the Achilles tendon of both groups were collected and submitted to a traction test in a conventional testing machine. The measurements of mechanical properties indicated that the elastic modulus (MPa) was significantly higher in the control group (
p
< 0.01). In Maximum tension (MPa), the groups did not have differences (
p
> 0.01). Energy/tendon area (N mm/mm
2
), specific strain (%) and maximum specific strain (mm) were higher in tendon tests of the diabetic group (
p
< 0.01). We observed that the mechanical properties of tendons have correlations with metabolic properties of the diabetic animals. These results showed that induced DM in rats have an important negative effect on the mechanical properties of the Achilles tendon.</description><subject>Achilles Tendon - metabolism</subject><subject>Achilles Tendon - pathology</subject><subject>Achilles Tendon - physiopathology</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Classical Mechanics</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Elasticity</subject><subject>Humans</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1P3DAQhq0KBMvHD-gFRVx6SpmxHX8cV5QCEqgFwdlykknJKusscSK1--vxamkrISFOM9I87zuaeRn7jPAVAfRZRJDC5oCYA5c6X39iMyy0yK0yaofNACzkyiq5zw5iXEACjSj22D5Hzgsh5Yzd3VL15ENb-S77OfQrGsaWYtY32bx6arsu9Q8U6j5kbcju_Riz61BPFdXZ2GcXvxPfLimMSf2t9SWNFI_YbuO7SMev9ZA9fr94OL_Kb35cXp_Pb_JKAh9zYwkVkC2bslHCk-SmqtEbbiSUWgoFmnhjqDbcogRLVFJqeFHYotFSiUP2Zeu7GvrnieLolm2sqOt8oH6KzmiJxnCBH5MKOUhAmcjTN-Sin4aQzkgQCI1KFwnCLVQNfYwDNW6VnuCHPw7BbXJx21xcerfb5OLWSXPyajyVS6r_Kf4GkQC-BWIahV80_N_8vusL6ICWwg</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>de Oliveira, Rodrigo Ribeiro</creator><creator>de Lira, Kamilla Dinah Santos</creator><creator>de Castro Silveira, Patrícia Verçoza</creator><creator>Coutinho, Marcos Paulo Galdino</creator><creator>Medeiros, Marcela Nicácio</creator><creator>Teixeira, Magno Felipe Holanda Barboza Inácio</creator><creator>de Moraes, Silvia Regina Arruda</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Mechanical Properties of Achilles Tendon in Rats Induced to Experimental Diabetes</title><author>de Oliveira, Rodrigo Ribeiro ; de Lira, Kamilla Dinah Santos ; de Castro Silveira, Patrícia Verçoza ; Coutinho, Marcos Paulo Galdino ; Medeiros, Marcela Nicácio ; Teixeira, Magno Felipe Holanda Barboza Inácio ; de Moraes, Silvia Regina Arruda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-89e160e9bfbf63ae428cd1a82840b743607e2f8ed8291409eebe91425595f7463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Achilles Tendon - metabolism</topic><topic>Achilles Tendon - pathology</topic><topic>Achilles Tendon - physiopathology</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Classical Mechanics</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Elasticity</topic><topic>Humans</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira, Rodrigo Ribeiro</creatorcontrib><creatorcontrib>de Lira, Kamilla Dinah Santos</creatorcontrib><creatorcontrib>de Castro Silveira, Patrícia Verçoza</creatorcontrib><creatorcontrib>Coutinho, Marcos Paulo Galdino</creatorcontrib><creatorcontrib>Medeiros, Marcela Nicácio</creatorcontrib><creatorcontrib>Teixeira, Magno Felipe Holanda Barboza Inácio</creatorcontrib><creatorcontrib>de Moraes, Silvia Regina Arruda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of biomedical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, Rodrigo Ribeiro</au><au>de Lira, Kamilla Dinah Santos</au><au>de Castro Silveira, Patrícia Verçoza</au><au>Coutinho, Marcos Paulo Galdino</au><au>Medeiros, Marcela Nicácio</au><au>Teixeira, Magno Felipe Holanda Barboza Inácio</au><au>de Moraes, Silvia Regina Arruda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical Properties of Achilles Tendon in Rats Induced to Experimental Diabetes</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>39</volume><issue>5</issue><spage>1528</spage><epage>1534</epage><pages>1528-1534</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>The aim of this study was to quantify the effect of chemically induced diabetes mellitus (DM) on the mechanical properties of the Achilles tendon of rats and correlate it with metabolic and biomechanical findings. Adult rats were selected randomly and assigned to two groups, the diabetic group consisted of animals receiving a dose of streptozotocin to induce type I diabetes and the control group. The animals were placed in metabolic cages for analysis of metabolism. Ten weeks after diabetes induction, the Achilles tendon of both groups were collected and submitted to a traction test in a conventional testing machine. The measurements of mechanical properties indicated that the elastic modulus (MPa) was significantly higher in the control group (
p
< 0.01). In Maximum tension (MPa), the groups did not have differences (
p
> 0.01). Energy/tendon area (N mm/mm
2
), specific strain (%) and maximum specific strain (mm) were higher in tendon tests of the diabetic group (
p
< 0.01). We observed that the mechanical properties of tendons have correlations with metabolic properties of the diabetic animals. These results showed that induced DM in rats have an important negative effect on the mechanical properties of the Achilles tendon.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21225344</pmid><doi>10.1007/s10439-011-0247-z</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-6964 |
| ispartof | Annals of biomedical engineering, 2011-05, Vol.39 (5), p.1528-1534 |
| issn | 0090-6964 1573-9686 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_874188231 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Achilles Tendon - metabolism Achilles Tendon - pathology Achilles Tendon - physiopathology Animals Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Classical Mechanics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Elasticity Humans Male Models, Biological Rats Rats, Wistar |
| title | Mechanical Properties of Achilles Tendon in Rats Induced to Experimental Diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T00%3A39%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanical%20Properties%20of%20Achilles%20Tendon%20in%20Rats%20Induced%20to%20Experimental%20Diabetes&rft.jtitle=Annals%20of%20biomedical%20engineering&rft.au=de%20Oliveira,%20Rodrigo%20Ribeiro&rft.date=2011-05-01&rft.volume=39&rft.issue=5&rft.spage=1528&rft.epage=1534&rft.pages=1528-1534&rft.issn=0090-6964&rft.eissn=1573-9686&rft_id=info:doi/10.1007/s10439-011-0247-z&rft_dat=%3Cproquest_cross%3E874188231%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=860371675&rft_id=info:pmid/21225344&rfr_iscdi=true |