HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: Its role in cell survival

► Fish RGCs can survive and regenerate their axons after optic nerve injury. ► HSP70 and HSF-1 are induced in the zebrafish RGCs within 30 min after axotomy. ► Inhibition of HSP70 expression conversely induces apoptotic cell death of RGCs. ► We conclude that HSP70 is a crucial factor for optic nerve...

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Veröffentlicht in:	Neurochemistry international 2011-07, Vol.58 (8), p.888-895
Hauptverfasser:	Nagashima, Mikiko, Fujikawa, Chieko, Mawatari, Kazuhiro, Mori, Yusuke, Kato, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell survival Cell Survival - physiology Danio rerio Eye and associated structures. Visual pathways and centers. Vision Freshwater Fundamental and applied biological sciences. Psychology HSF1 HSP70 HSP70 Heat-Shock Proteins - biosynthesis Nerve Regeneration - physiology Optic Nerve - physiology Optic Nerve Injuries - genetics Optic Nerve Injuries - metabolism Optic nerve regeneration Retinal ganglion cell Retinal Ganglion Cells - physiology Transcription, Genetic - physiology Vertebrates: nervous system and sense organs Zebrafish Zebrafish Proteins - biosynthesis Zebrafish retina
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