Pathogen-specific IgG antibody levels in immunodeficient patients receiving immunoglobulin replacement do not provide additional benefit to therapeutic management over total serum IgG

[...]there was no difference between intravenous or subcutaneous route of infusion to the profile of PCP-Ab (P = .90; 2-tailed Mann-Whitney test) and HIB-Ab (P = .33; 2-tailed Mann-Whitney test). [...]our findings showed a consistent relationship between PCP-Ab and HIB-Ab with total IgG; in general,...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2011-06, Vol.127 (6), p.1410-1411
Hauptverfasser:	Chua, Ignatius, MBChB, MRCP, Lagos, Macarena, MD, Charalambous, Bambos M., PhD, Workman, Sarita, RN, MSc, Chee, Ronnie, MBBS, MRCP, MRCPath, Grimbacher, Bodo, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibodies, Bacterial - blood Antibody Specificity Bacterial Infections - etiology Bacterial Infections - immunology Binding sites Biological and medical sciences Clostridium tetani - immunology Drug therapy Fundamental and applied biological sciences. Psychology Fundamental immunology Haemophilus influenzae type b - immunology Humans Immunoassay Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G - blood Immunoglobulins, Intravenous - therapeutic use Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - therapy Immunopathology Medical sciences Older people Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Streptococcus infections Streptococcus pneumoniae - immunology Tetanus
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Zusammenfassung:	[...]there was no difference between intravenous or subcutaneous route of infusion to the profile of PCP-Ab (P = .90; 2-tailed Mann-Whitney test) and HIB-Ab (P = .33; 2-tailed Mann-Whitney test). [...]our findings showed a consistent relationship between PCP-Ab and HIB-Ab with total IgG; in general, higher total IgG correlates with higher pathogen-specific antibody levels.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2011.01.035