Radiolabeled cetuximab: Dose optimization for epidermal growth factor receptor imaging in a head‐and‐neck squamous cell carcinoma model

Noninvasive imaging of the epidermal growth factor receptor (EGFR) in head‐and‐neck squamous cell carcinoma could be of value to select patients for EGFR‐targeted therapy. We assessed dose optimization of 111Indium‐DTPA‐cetuximab (111In‐cetuximab) for EGFR imaging in a head‐and‐neck squamous cell ca...

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Veröffentlicht in:	International journal of cancer 2011-08, Vol.129 (4), p.870-878
Hauptverfasser:	Hoeben, Bianca A.W., Molkenboer‐Kuenen, Janneke D.M., Oyen, Wim J.G., Peeters, Wenny J.M., Kaanders, Johannes H.A.M., Bussink, Johan, Boerman, Otto C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal, Humanized antibody Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological and medical sciences Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Cetuximab Fluorescent Antibody Technique Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism head‐and‐neck cancer Immunoenzyme Techniques Indium Radioisotopes - pharmacokinetics Medical sciences Mice Mice, Inbred BALB C Mice, Nude Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pentetic Acid - pharmacokinetics preclinical imaging Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - immunology Receptor, Epidermal Growth Factor - metabolism SPECT Tissue Distribution Tomography, Emission-Computed, Single-Photon Tumors Xenograft Model Antitumor Assays
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