Impact of Select Immunologic and Virologic Biomarkers on CD4 Cell Count Decrease in Patients with Chronic HIV-1 Subtype C Infection: Results from Sinikithemba Cohort, Durban, South Africa

Background.The extent to which immunologic and clinical biomarkers influence human immunodeficiency virus type 1 (HIV-1) infection outcomes remains incompletely characterized, particularly for non-B subtypes. On the basis of data supporting in vitro HIV-1 protein-specific CD8 T lymphocyte responses...

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Veröffentlicht in:	Clinical infectious diseases 2009-09, Vol.49 (6), p.956-964
Hauptverfasser:	Brumme, Zabrina, Wang, Bingxia, Nair, Kriebashne, Brumme, Chanson, de Pierres, Chantal, Reddy, Shabashini, Julg, Boris, Moodley, Eshia, Thobakgale, Christina, Lu, Zhigang, van der Stok, Mary, Bishop, Karen, Mncube, Zenele, Chonco, Fundisiwe, Yuki, Yuko, Frahm, Nicole, Brander, Christian, Carrington, Mary, Freedberg, Kenneth, Kiepiela, Photini, Goulder, Philip, Walker, Bruce, Ndung'u, Thumbi, Losina, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Alleles Biological and medical sciences Biological markers Biomarkers Biomarkers - blood CD4 antigen CD4 Lymphocyte Count CD4-CD8 Ratio CD8 antigen CD8-Positive T-Lymphocytes - immunology Cells Chronic infection Clinical medicine Cohort Studies Data processing Female Histocompatibility antigen HLA HIV HIV 1 HIV Infections - immunology HIV Infections - virology HIV/AIDS HLA antigens HLA Antigens - genetics Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunology Immunopathology Infections Infectious diseases Longitudinal Studies Lymphocytes T Male Medical sciences Multivariate Analysis Predictive Value of Tests South Africa Statistical significance T lymphocytes Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology
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