Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols
Objectives: Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. Methods: B6C3F1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100...
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| Veröffentlicht in: | Journal of Occupational Health 2011, Vol.53 (3), p.234-239 |
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| container_title | Journal of Occupational Health |
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| creator | Nagano, Kasuke Nishizawa, Tomoshi Eitaki, Yoko Ohnishi, Makoto Noguchi, Tadashi Arito, Heihachiro Fukushima, Shoji |
| description | Objectives: Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. Methods: B6C3F1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m3 or 13 wk at 0, 0.1 or 1 mg/m3. Results: ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and increased lung weight were induced by 2- and 13-week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2-week exposures. Thickened pleural wall, hyperplastic MLN, extramedullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13-week exposure to ITO. The ITO- and IO-induced pulmonary lesions were milder in mice than those previously reported in rats, and the fibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13-week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds. |
| doi_str_mv | 10.1539/joh.10-0053-br |
| format | Article |
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Methods: B6C3F1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m3 or 13 wk at 0, 0.1 or 1 mg/m3. Results: ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and increased lung weight were induced by 2- and 13-week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2-week exposures. Thickened pleural wall, hyperplastic MLN, extramedullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13-week exposure to ITO. The ITO- and IO-induced pulmonary lesions were milder in mice than those previously reported in rats, and the fibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13-week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds.</description><identifier>ISSN: 1341-9145</identifier><identifier>ISSN: 1348-9585</identifier><identifier>EISSN: 1348-9585</identifier><identifier>DOI: 10.1539/joh.10-0053-br</identifier><identifier>PMID: 21422720</identifier><language>eng</language><publisher>Australia: JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</publisher><subject>Aerosols ; Animals ; Exposure ; Female ; Indium ; Indium - blood ; Indium - toxicity ; Indium - urine ; Indium oxide ; Indium‐tin oxide ; Inhalation ; Inhalation Exposure ; Lesions ; Lung ; Lung - drug effects ; Lung - pathology ; Macrophages, Alveolar - drug effects ; Male ; Mice ; Mouse ; Occupational health ; Pulmonary Alveolar Proteinosis - chemically induced ; Pulmonary Alveolar Proteinosis - pathology ; Spleen - drug effects ; Spleen - pathology ; Tin Compounds - blood ; Tin Compounds - toxicity ; Tin Compounds - urine ; Toxicity</subject><ispartof>Journal of Occupational Health, 2011, Vol.53 (3), p.234-239</ispartof><rights>2011 Japan Society for Occupational Health</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6550-cdfe327da0aa7879c79eb11d817015aa5a3e6dbbf7782858995f11d9b9e1efb63</citedby><cites>FETCH-LOGICAL-c6550-cdfe327da0aa7879c79eb11d817015aa5a3e6dbbf7782858995f11d9b9e1efb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1539%2Fjoh.10-0053-BR$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1539%2Fjoh.10-0053-BR$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21422720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagano, Kasuke</creatorcontrib><creatorcontrib>Nishizawa, Tomoshi</creatorcontrib><creatorcontrib>Eitaki, Yoko</creatorcontrib><creatorcontrib>Ohnishi, Makoto</creatorcontrib><creatorcontrib>Noguchi, Tadashi</creatorcontrib><creatorcontrib>Arito, Heihachiro</creatorcontrib><creatorcontrib>Fukushima, Shoji</creatorcontrib><creatorcontrib>Japan Industrial Safety and Health Association</creatorcontrib><creatorcontrib>Japan Bioassay Research Center</creatorcontrib><creatorcontrib>Occupational Health Research and Development Center</creatorcontrib><title>Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols</title><title>Journal of Occupational Health</title><addtitle>J Occup Health</addtitle><description>Objectives: Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. Methods: B6C3F1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m3 or 13 wk at 0, 0.1 or 1 mg/m3. Results: ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and increased lung weight were induced by 2- and 13-week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2-week exposures. Thickened pleural wall, hyperplastic MLN, extramedullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13-week exposure to ITO. The ITO- and IO-induced pulmonary lesions were milder in mice than those previously reported in rats, and the fibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13-week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds.</description><subject>Aerosols</subject><subject>Animals</subject><subject>Exposure</subject><subject>Female</subject><subject>Indium</subject><subject>Indium - blood</subject><subject>Indium - toxicity</subject><subject>Indium - urine</subject><subject>Indium oxide</subject><subject>Indium‐tin oxide</subject><subject>Inhalation</subject><subject>Inhalation Exposure</subject><subject>Lesions</subject><subject>Lung</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Macrophages, Alveolar - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mouse</subject><subject>Occupational health</subject><subject>Pulmonary Alveolar Proteinosis - chemically induced</subject><subject>Pulmonary Alveolar Proteinosis - pathology</subject><subject>Spleen - drug effects</subject><subject>Spleen - pathology</subject><subject>Tin Compounds - blood</subject><subject>Tin Compounds - toxicity</subject><subject>Tin Compounds - urine</subject><subject>Toxicity</subject><issn>1341-9145</issn><issn>1348-9585</issn><issn>1348-9585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1DAUjBCIVqVXjsgSB05e_Ow4to-lKm1R0SJUzpaTvGhdkniJE3X373E2C5W4lIs9Gs-M_d5zlr0FtgIpzMeHsFkBo4xJQcvhRXYKItfUSC1fHjBQA7k8yc5j9CXjAqSCQrzOTjjknCvOTrPwbWq70LthT-7Dzld-3BPfk6--QlLuCafE9TUBQR8Rf5LbfuNaN_rQk6vdNsRpwEjGkPjaTx0dk3O98zUeTAt5JC5wCDG08U32qnFtxPPjfpb9-Hx1f3lD79bXt5cXd7QqpGS0qhsUXNWOOae0MpUyWALUGhQD6Zx0Aou6LBulNNdSGyObdGxKg4BNWYiz7MOSux3CrwnjaDsfK2xb12OYotUqB81TP_5DKYDnTM_K9_8oH8I09KkMC3kulCoMn29eLaoqVRwHbOx28F1qsAVm57El12bG89jsp-_J8O4YO5Ud1n_lf4aUBGYRPPoW98_E2S_rG54gY4LB7L1evCnZV64Nfet7fHp41agDtpwBHDKYsGyO4yKfl_SDCqMNiN_5ILmg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Nagano, Kasuke</creator><creator>Nishizawa, Tomoshi</creator><creator>Eitaki, Yoko</creator><creator>Ohnishi, Makoto</creator><creator>Noguchi, Tadashi</creator><creator>Arito, Heihachiro</creator><creator>Fukushima, Shoji</creator><general>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>2011</creationdate><title>Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols</title><author>Nagano, Kasuke ; Nishizawa, Tomoshi ; Eitaki, Yoko ; Ohnishi, Makoto ; Noguchi, Tadashi ; Arito, Heihachiro ; Fukushima, Shoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6550-cdfe327da0aa7879c79eb11d817015aa5a3e6dbbf7782858995f11d9b9e1efb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aerosols</topic><topic>Animals</topic><topic>Exposure</topic><topic>Female</topic><topic>Indium</topic><topic>Indium - blood</topic><topic>Indium - toxicity</topic><topic>Indium - urine</topic><topic>Indium oxide</topic><topic>Indium‐tin oxide</topic><topic>Inhalation</topic><topic>Inhalation Exposure</topic><topic>Lesions</topic><topic>Lung</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Macrophages, Alveolar - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mouse</topic><topic>Occupational health</topic><topic>Pulmonary Alveolar Proteinosis - chemically induced</topic><topic>Pulmonary Alveolar Proteinosis - pathology</topic><topic>Spleen - drug effects</topic><topic>Spleen - pathology</topic><topic>Tin Compounds - blood</topic><topic>Tin Compounds - toxicity</topic><topic>Tin Compounds - urine</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagano, Kasuke</creatorcontrib><creatorcontrib>Nishizawa, Tomoshi</creatorcontrib><creatorcontrib>Eitaki, Yoko</creatorcontrib><creatorcontrib>Ohnishi, Makoto</creatorcontrib><creatorcontrib>Noguchi, Tadashi</creatorcontrib><creatorcontrib>Arito, Heihachiro</creatorcontrib><creatorcontrib>Fukushima, Shoji</creatorcontrib><creatorcontrib>Japan Industrial Safety and Health Association</creatorcontrib><creatorcontrib>Japan Bioassay Research Center</creatorcontrib><creatorcontrib>Occupational Health Research and Development Center</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>Journal of Occupational Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagano, Kasuke</au><au>Nishizawa, Tomoshi</au><au>Eitaki, Yoko</au><au>Ohnishi, Makoto</au><au>Noguchi, Tadashi</au><au>Arito, Heihachiro</au><au>Fukushima, Shoji</au><aucorp>Japan Industrial Safety and Health Association</aucorp><aucorp>Japan Bioassay Research Center</aucorp><aucorp>Occupational Health Research and Development Center</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols</atitle><jtitle>Journal of Occupational Health</jtitle><addtitle>J Occup Health</addtitle><date>2011</date><risdate>2011</risdate><volume>53</volume><issue>3</issue><spage>234</spage><epage>239</epage><pages>234-239</pages><issn>1341-9145</issn><issn>1348-9585</issn><eissn>1348-9585</eissn><abstract>Objectives: Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. Methods: B6C3F1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m3 or 13 wk at 0, 0.1 or 1 mg/m3. Results: ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and increased lung weight were induced by 2- and 13-week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2-week exposures. Thickened pleural wall, hyperplastic MLN, extramedullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13-week exposure to ITO. The ITO- and IO-induced pulmonary lesions were milder in mice than those previously reported in rats, and the fibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13-week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds.</abstract><cop>Australia</cop><pub>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</pub><pmid>21422720</pmid><doi>10.1539/joh.10-0053-br</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Journals; Oxford Journals Open Access Collection; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Aerosols Animals Exposure Female Indium Indium - blood Indium - toxicity Indium - urine Indium oxide Indium‐tin oxide Inhalation Inhalation Exposure Lesions Lung Lung - drug effects Lung - pathology Macrophages, Alveolar - drug effects Male Mice Mouse Occupational health Pulmonary Alveolar Proteinosis - chemically induced Pulmonary Alveolar Proteinosis - pathology Spleen - drug effects Spleen - pathology Tin Compounds - blood Tin Compounds - toxicity Tin Compounds - urine Toxicity |
| title | Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols |
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