Biological evaluation of novel benzisoxazole derivatives as PPAR[delta] agonists

Biological evaluation of novel benzisoxazole derivatives as PPAR[delta] agonists

We discovered novel peroxisome proliferator-activated receptor [delta] agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPAR[delta] transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2011-05, Vol.19 (10), p.3255-3264
Hauptverfasser: Sakuma, Shogo, Endo, Tsuyoshi, Kanda, Takashi, Nakamura, Hideki, Yamasaki, Satomi, Yamakawa, Tomio
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container_title Bioorganic & medicinal chemistry
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creator Sakuma, Shogo
Endo, Tsuyoshi
Kanda, Takashi
Nakamura, Hideki
Yamasaki, Satomi
Yamakawa, Tomio
description We discovered novel peroxisome proliferator-activated receptor [delta] agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPAR[delta] transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates that this potential drug may be effective for the treatment of demyelinating disorders such as multiple sclerosis.
doi_str_mv 10.1016/j.bmc.2011.03.053
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title Biological evaluation of novel benzisoxazole derivatives as PPAR[delta] agonists
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