PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect

Protein phosphatase 2A (PP2A) is a human tumor suppressor that inhibits cellular transformation by regulating the activity of several signaling proteins critical for malignant cell behavior. PP2A has been described as a potential therapeutic target in chronic myeloid leukemia, Philadelphia chromosom...

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Veröffentlicht in:	Leukemia 2011-04, Vol.25 (4), p.606-614
Hauptverfasser:	Cristóbal, I, Garcia-Orti, L, Cirauqui, C, Alonso, M M, Calasanz, M J, Odero, M D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/609 692/699/67/1059/602 692/699/67/1990/283/1897 Acute lymphoblastic leukemia Acute myeloid leukemia AKT protein Apoptosis Apoptosis - drug effects Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Bone Marrow Cancer Research Case-Control Studies Caspase Caspases - metabolism Cell proliferation Cell Proliferation - drug effects Cellular signal transduction Chronic lymphocytic leukemia Chronic myeloid leukemia Colforsin - therapeutic use Critical Care Medicine Deregulation Drug development Enzyme Activation - drug effects Female Forskolin FTY720 Gene Expression Profiling Hematologic and hematopoietic diseases Hematology Humans Immunoenzyme Techniques Inactivation Induction therapy Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Lymphocytes B Male Medical sciences Medicine Medicine & Public Health Middle Aged Oligonucleotide Array Sequence Analysis Oncology original-article Patients Philadelphia chromosome Phosphatase Phosphoprotein phosphatase Phosphorylation Phosphorylation - drug effects Physiological aspects Prognosis Protein kinases Protein phosphatase Protein Phosphatase 2 - antagonists & inhibitors Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Proteins Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Therapeutic applications Therapeutic targets Tumor Cells, Cultured Tumor suppressor genes Tumors
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