Leukocyte DNA damage in children with iron deficiency anemia: effect of iron supplementation

Iron deficiency is frequently associated with anemia. Iron is a transition-metal ion, and it can induce free radical formation, which leads to formation of various lesions in DNA, proteins, and lipids. The aim of this study was to investigate baseline oxidative DNA damage and to clarify the role of...

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Veröffentlicht in:	European journal of pediatrics 2010-08, Vol.169 (8), p.951-956
Hauptverfasser:	Aksu, Bagdagul Y., Hasbal, Canan, Himmetoglu, Solen, Dincer, Yildiz, Koc, Eylem E., Hatipoglu, Sami, Akcay, Tulay
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - drug therapy Anemia, Iron-Deficiency - genetics Anemias. Hemoglobinopathies Biological and medical sciences Blood Cell Count Child Children & youth Comet Assay - methods Deoxyribonucleic acid Diseases of red blood cells DNA DNA Damage Female Ferric Compounds - administration & dosage Ferric Compounds - pharmacology Ferric Compounds - therapeutic use Ferritins - blood General aspects Hematologic and hematopoietic diseases Humans Iron Iron - blood Iron-Binding Proteins - blood Leukocytes - drug effects Leukocytes - metabolism Male Medical sciences Medicine Medicine & Public Health Metabolic diseases Metals (hemochromatosis...) Original Paper Other metabolic disorders Pediatrics Treatment Outcome Young Adult
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