CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury

The synthetic sphingosine-1-phosphate (S1P) analogue, FTY720, attenuates ischaemia/reperfusion (I/R) injury by inducing peripheral lymphopaenia. Recent studies suggest that FTY720 may also exert protective effects by modulating dendritic cell (DC) function or directly affecting regulatory T cells (T...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2011, Vol.26 (1), p.111-124
Hauptverfasser:	KIM, Myung-Gyu, SO YOUNG LEE, YOON SOOK KO, HEE YOUNG LEE, JO, Sang-Kyung, WON YONG CHO, KIM, Hyoung-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Emergency and intensive care: renal failure. Dialysis management Fingolimod Hydrochloride Flow Cytometry Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Immunosuppressive Agents - pharmacology Intensive care medicine Interleukin-2 Receptor alpha Subunit - metabolism Kidney - cytology Kidney - immunology Kidney - metabolism Lymphocyte Culture Test, Mixed Lymphopenia - etiology Lysophospholipids Male Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Propylene Glycols - pharmacology Reperfusion Injury - complications Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sphingosine - analogs & derivatives Sphingosine - pharmacology Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocytes, Regulatory - immunology Urinary system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!