Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial

The role of pharmacogenomics and tamoxifen was investigated by analyzing several polymorphisms of cytochrome P450 and SULT1A1 gene in a nested case control study from the Italian Tamoxifen Prevention Trial. This study included 182 Caucasian subjects, 47 breast cancer (BC) cases and 135 matched contr...

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Veröffentlicht in:	The pharmacogenomics journal 2011-04, Vol.11 (2), p.100-107
Hauptverfasser:	Serrano, D, Lazzeroni, M, Zambon, C-F, Macis, D, Maisonneuve, P, Johansson, H, Guerrieri-Gonzaga, A, Plebani, M, Basso, D, Gjerde, J, Mellgren, G, Rotmensz, N, Decensi, A, Bonanni, B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/436/108 692/699/67/1347 692/699/67/1857 692/700/565/1436/434 Alleles Antineoplastic Agents, Hormonal - therapeutic use Aryl Hydrocarbon Hydroxylases - genetics Arylsulfotransferase - genetics Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - prevention & control Care and treatment Case-Control Studies Clinical Trials as Topic Complications and side effects CYP2D6 protein Cytochrome Cytochrome P-450 Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2D6 - genetics Cytochrome P450 Drug Resistance, Neoplasm - genetics Female Gene Expression Health aspects Human Genetics Humans Italy Middle Aged Oncology original-article Pharmacogenomics Pharmacotherapy Phenotypes Polymorphism, Single Nucleotide Prevention Psychopharmacology Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Tamoxifen Tamoxifen - therapeutic use Treatment Outcome
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