Human mitochondrial transcription factor A is required for the segregation of mitochondrial DNA in cultured cells

The segregation and transmission of the mitochondrial genome in humans are complicated processes but are particularly important for understanding the inheritance and clinical abnormalities of mitochondrial disorders. However, the molecular mechanism of the segregation of mitochondrial DNA (mtDNA) is...

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Veröffentlicht in:	Experimental cell research 2011-01, Vol.317 (2), p.210-220
Hauptverfasser:	Kasashima, Katsumi, Sumitani, Megumi, Endo, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell culture Cells, Cultured DNA - genetics DNA, Mitochondrial - genetics DNA-Binding Proteins - metabolism Fluorescent Dyes - metabolism Genetic Complementation Test HeLa Cells Humans In Situ Hybridization, Fluorescence Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins - metabolism mtDNA Nucleoid Organic Chemicals - metabolism RNA Interference Segregation TFAM Transcription Factors - metabolism Transfection
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