A Conserved Lysine Residue in the Crenarchaea-Specific Loop is Important for the Crenarchaeal Splicing Endonuclease Activity

In Archaea, splicing endonuclease (EndA) recognizes and cleaves precursor RNAs to remove introns. Currently, EndAs are classified into three families according to their subunit structures: homotetramer, homodimer, and heterotetramer. The crenarchaeal heterotetrameric EndAs can be further classified...

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Veröffentlicht in:	Journal of molecular biology 2011-01, Vol.405 (1), p.92-104
Hauptverfasser:	Okuda, Maho, Shiba, Tomoo, Inaoka, Daniel-Ken, Kita, Kiyoshi, Kurisu, Genji, Mineki, Shigeru, Harada, Shigeharu, Watanabe, Yoh-ichi, Yoshinari, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aeropyrum - chemistry Aeropyrum - enzymology Aeropyrum - genetics Aeropyrum pernix Amino Acid Sequence amino acid sequences Amino Acid Substitution - genetics Archaea Catalytic Domain convergent evolution Crenarchaea crystal structure Crystallography, X-Ray Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - metabolism Evolution, Molecular intron introns lysine Lysine - chemistry Lysine - genetics Lysine - metabolism Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Quaternary protein subunits Pyrobaculum aerophilum RNA RNA Splicing RNA, Archaeal - metabolism Sequence Alignment splicing endonuclease subunit structure tRNA splicing
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