TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability

The innate immune response is influenced by the nutrient status of the host. Mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase 1 (ERK1) and ERK2, are activated after the stimulation of macrophages with bacterial lipopolysaccharide (LPS) and are necessary for th...

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Veröffentlicht in:	Science signaling 2010-08, Vol.3 (135), p.ra61-ra61
Hauptverfasser:	Mieulet, Virginie, Yan, Lijun, Choisy, Caroline, Sully, Katherine, Procter, Julia, Kouroumalis, Andreas, Krywawych, Steve, Pende, Mario, Ley, Steven C, Moinard, Christophe, Lamb, Richard F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - blood Animals Arginine - metabolism Arginine - pharmacology Blotting, Western Chromatography, Ion Exchange Enzyme Activation - drug effects Enzyme Activation - immunology Immunity, Innate - physiology Immunohistochemistry Lipopolysaccharides Macrophages - immunology MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Mice Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Signal Transduction - immunology Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - biosynthesis
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