Efficient and targeted delivery of siRNA in vivo

RNA interference (RNAi) has been regarded as a revolutionary tool for manipulating target biological processes as well as an emerging and promising therapeutic strategy. In contrast to the tangible and obvious effectiveness of RNAi in vitro, silencing target gene expression in vivo using small inter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FEBS journal 2010-12, Vol.277 (23), p.4814-4827
Hauptverfasser:	Shim, Min Suk, Kwon, Young Jik
Format:	Artikel
Sprache:	eng
Schlagworte:	administration routes Animals Aptamers, Nucleotide - administration & dosage barriers in siRNA delivery Biochemistry chemically modified RNA Cholesterol - administration & dosage Drug Carriers Drug Delivery Systems Drug Design Gene expression Genetic Engineering Genetic Therapy - methods Genetic Vectors Humans in vivo disease models Liposomes nanoparticles nonviral carriers nucleic acid therapeutics Polymers Research methodology Ribonucleic acid RNA RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use targeted delivery in vivo viral vectors Viruses Viruses - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!