Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6
Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking. Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO. Methods: We measured...
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| Veröffentlicht in: | Multiple sclerosis 2010-12, Vol.16 (12), p.1443-1452 |
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| creator | Uzawa, Akiyuki Mori, Masahiro Arai, Kimihito Sato, Yasunori Hayakawa, Sei Masuda, Saeko Taniguchi, Junko Kuwabara, Satoshi |
| description | Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking.
Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO.
Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined.
Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers.
Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO. |
| doi_str_mv | 10.1177/1352458510379247 |
| format | Article |
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Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO.
Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined.
Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers.
Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/1352458510379247</identifier><identifier>PMID: 20739337</identifier><identifier>CODEN: MUSCFZ</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Chemokines - blood ; Chemokines - cerebrospinal fluid ; Cytokines - blood ; Cytokines - cerebrospinal fluid ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Immunoassay ; Immunohistochemistry ; Interleukin-6 - blood ; Interleukin-6 - cerebrospinal fluid ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - cerebrospinal fluid ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - cerebrospinal fluid</subject><ispartof>Multiple sclerosis, 2010-12, Vol.16 (12), p.1443-1452</ispartof><rights>The Author(s) 2010</rights><rights>2015 INIST-CNRS</rights><rights>SAGE Publications © Dec 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-7c33436bf524db97e2162b9774f53f796220c3f9ad61e530ff060e9fb33cfb6e3</citedby><cites>FETCH-LOGICAL-c491t-7c33436bf524db97e2162b9774f53f796220c3f9ad61e530ff060e9fb33cfb6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1352458510379247$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1352458510379247$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23747143$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20739337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uzawa, Akiyuki</creatorcontrib><creatorcontrib>Mori, Masahiro</creatorcontrib><creatorcontrib>Arai, Kimihito</creatorcontrib><creatorcontrib>Sato, Yasunori</creatorcontrib><creatorcontrib>Hayakawa, Sei</creatorcontrib><creatorcontrib>Masuda, Saeko</creatorcontrib><creatorcontrib>Taniguchi, Junko</creatorcontrib><creatorcontrib>Kuwabara, Satoshi</creatorcontrib><title>Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking.
Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO.
Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined.
Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers.
Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chemokines - blood</subject><subject>Chemokines - cerebrospinal fluid</subject><subject>Cytokines - blood</subject><subject>Cytokines - cerebrospinal fluid</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunohistochemistry</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - cerebrospinal fluid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - cerebrospinal fluid</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtLAzEQx4MoPqp3T7II4mk12cnuGG9SfEHBi3pdsumkRvdRk91Dv70prQoFMZeZML95_hk7FvxCCMRLAXkm86tccECVSdxi-0Iiplwh345-DKfL-B47COGdc44I-S7byziCAsB99jpe9N2HaynR7TQxb9SsfnPfWVdTSFybtDT4rllQ7XoXkm7eO6Ovk-BmrbPRbQ0lnY1gT76mIaanxSHbsboOdLS2I_Zyd_s8fkgnT_eP45tJaqQSfYoGQEJR2bjGtFJImSiyaFHaHCyqIsu4Aav0tBCUA7eWF5yUrQCMrQqCETtf1Y3zfg4U-rJxwVBd65a6IZRXKAUqzrP_SZHHJ-JhRux0g3zvBt_GNZaQUCCxiBBfQcZ3IXiy5dy7RvtFKXi51Kbc1CamnKzrDlVD05-EbzEicLYGdDC6tj6e1oVfDlCikBC5dMUFPaPf4f5s_AXv16Ic</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Uzawa, Akiyuki</creator><creator>Mori, Masahiro</creator><creator>Arai, Kimihito</creator><creator>Sato, Yasunori</creator><creator>Hayakawa, Sei</creator><creator>Masuda, Saeko</creator><creator>Taniguchi, Junko</creator><creator>Kuwabara, Satoshi</creator><general>SAGE Publications</general><general>Sage Publications</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6</title><author>Uzawa, Akiyuki ; Mori, Masahiro ; Arai, Kimihito ; Sato, Yasunori ; Hayakawa, Sei ; Masuda, Saeko ; Taniguchi, Junko ; Kuwabara, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-7c33436bf524db97e2162b9774f53f796220c3f9ad61e530ff060e9fb33cfb6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chemokines - blood</topic><topic>Chemokines - cerebrospinal fluid</topic><topic>Cytokines - blood</topic><topic>Cytokines - cerebrospinal fluid</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunohistochemistry</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - cerebrospinal fluid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uzawa, Akiyuki</creatorcontrib><creatorcontrib>Mori, Masahiro</creatorcontrib><creatorcontrib>Arai, Kimihito</creatorcontrib><creatorcontrib>Sato, Yasunori</creatorcontrib><creatorcontrib>Hayakawa, Sei</creatorcontrib><creatorcontrib>Masuda, Saeko</creatorcontrib><creatorcontrib>Taniguchi, Junko</creatorcontrib><creatorcontrib>Kuwabara, Satoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uzawa, Akiyuki</au><au>Mori, Masahiro</au><au>Arai, Kimihito</au><au>Sato, Yasunori</au><au>Hayakawa, Sei</au><au>Masuda, Saeko</au><au>Taniguchi, Junko</au><au>Kuwabara, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>16</volume><issue>12</issue><spage>1443</spage><epage>1452</epage><pages>1443-1452</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><coden>MUSCFZ</coden><abstract>Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking.
Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO.
Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/ chemokines were also measured. The correlations between clinical characteristics/laboratory findings and levels of cytokines/chemokines in NMO were examined.
Results: The CSF levels of interleukin (IL)-1 receptor antagonist, IL-6, IL-8, IL-13 and granulocyte colony-stimulating factor were significantly increased in NMO, while IL-9, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor, macrophage inflammatory protein-1-beta and tumor necrosis factor-alpha were increased in MS. IL-10 and interferon-gamma-inducible protein-10 were elevated in NMO and MS. In serum analyses, only the IL-6 level showed significant elevation in NMO. The CSF IL-6 level had a significant correlation with the CSF glial fibrillary acidic protein level and CSF cells, and a weak correlation with anti-aquaporin-4 antibody titers.
Conclusions: Different immunological status and pathophysiologies exist between NMO and MS, and IL-6 may play important roles in the pathogenesis of NMO.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>20739337</pmid><doi>10.1177/1352458510379247</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Chemokines - blood Chemokines - cerebrospinal fluid Cytokines - blood Cytokines - cerebrospinal fluid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Immunoassay Immunohistochemistry Interleukin-6 - blood Interleukin-6 - cerebrospinal fluid Male Medical sciences Middle Aged Multiple Sclerosis - cerebrospinal fluid Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuromyelitis Optica - blood Neuromyelitis Optica - cerebrospinal fluid |
| title | Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6 |
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