Portfolio management in early stage drug discovery – a traveler's guide through uncharted territory
Portfolio management in drug development has become a best practice in the pharmaceutical industry. By contrast, early on in the value chain – the discovery phase – portfolio management is still in its infancy. Nevertheless, owing to the attrition of R&D projects from phase to phase and the cost...
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| Veröffentlicht in: | Drug discovery today 2011-07, Vol.16 (13), p.609-618 |
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| container_title | Drug discovery today |
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| creator | Betz, Ulrich A.K. |
| description | Portfolio management in drug development has become a best practice in the pharmaceutical industry. By contrast, early on in the value chain – the discovery phase – portfolio management is still in its infancy. Nevertheless, owing to the attrition of R&D projects from phase to phase and the cost of capital involved, these early phases of drug discovery play a significant part for the overall cost of bringing new, innovative drugs to the market. This paper describes various approaches to manage a portfolio of projects in early-stage drug discovery and provides crucial factors that determine the success of such an approach. |
| doi_str_mv | 10.1016/j.drudis.2011.04.012 |
| format | Article |
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| ispartof | Drug discovery today, 2011-07, Vol.16 (13), p.609-618 |
| issn | 1359-6446 1878-5832 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Attrition Best practice Biological and medical sciences Drug Design Drug Discovery - economics Drug Discovery - methods Drug Industry - economics Drug Industry - methods Drugs Efficiency, Organizational General pharmacology Humans Management Marketing Markets Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Product innovation Research - economics Research Design Value analysis |
| title | Portfolio management in early stage drug discovery – a traveler's guide through uncharted territory |
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