Diagnostic value of whole-body magnetic resonance imaging for bone metastases: a systematic review and meta-analysis
Purpose: To assess the overall diagnostic accuracy of whole‐body magnetic resonance imaging (WB‐MRI) in detecting bone metastases with a meta‐analysis. Materials and Methods: The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2011-07, Vol.34 (1), p.128-135 |
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| creator | Wu, Lian-Ming Gu, Hai-Yan Zheng, Jasmine Xu, Xiao Lin, Lin-Hua Deng, Xia Zhang, Wei Xu, Jian-Rong |
| description | Purpose:
To assess the overall diagnostic accuracy of whole‐body magnetic resonance imaging (WB‐MRI) in detecting bone metastases with a meta‐analysis.
Materials and Methods:
The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB‐MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow‐up for at least 6 months was assessed. Meta‐analysis methods were used to pool sensitivity and specificity and to construct summary receiver‐operating characteristics.
Results:
A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB‐MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845–0.939) and a pooled specificity of 0.918 (95% CI, 0.882–0.946). The subgroup without diffusion‐weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922‐0.984) than the subgroup with DWI (P < 0.05).
Conclusion:
WB‐MRI was an accurate, cost‐effective tool in detecting bone metastases. WB‐MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High‐quality prospective studies regarding WB‐MRI in detecting bone metastases still need to be conducted. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.22608 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_873702849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>873702849</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4688-237f1cae4dd712fa68f1baea8d93a66b3491061b36606a14af07fd906cbbb293</originalsourceid><addsrcrecordid>eNp9kF9P1TAYhxsjEURv_ACmdyYmg_7Zus47gwroQYgh4bJ5u73F4rZCu8Nx394eBlyaNGnT9_n90j6EvOPsgDMmDm-G6A-EUEy_IHu8EqIQlVYv85lVsuCa1bvkdUo3jLGmKatXZFdwxbWUco9MXzxcjyFNvqX30K-RBkc3v0OPhQ3dTIc8xe0wYgojjC1Sn-_8eE1diNSGEemAE6S8MH2iQNOcJhxgydx73FAYuwemgBH6Ofn0huw46BO-fdz3yeW3r5dHJ8Xq_Pj06POqaEuldSFk7XgLWHZdzYUDpR23gKC7RoJSVpYNZ4pbqRRTwEtwrHZdw1RrrRWN3CcfltrbGO7WmCYz-NRi38OIYZ2MrmXNhC635MeFbGNIKaIztzF_M86GM7N1bLaOzYPjDL9_rF3bAbtn9ElqBvgCbHyP83-qzPezX6dPpcWS8dne3-cMxD9G5WdW5urnsZFqdXbx4-rEVPIfEu6YRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>873702849</pqid></control><display><type>article</type><title>Diagnostic value of whole-body magnetic resonance imaging for bone metastases: a systematic review and meta-analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><creator>Wu, Lian-Ming ; Gu, Hai-Yan ; Zheng, Jasmine ; Xu, Xiao ; Lin, Lin-Hua ; Deng, Xia ; Zhang, Wei ; Xu, Jian-Rong</creator><creatorcontrib>Wu, Lian-Ming ; Gu, Hai-Yan ; Zheng, Jasmine ; Xu, Xiao ; Lin, Lin-Hua ; Deng, Xia ; Zhang, Wei ; Xu, Jian-Rong</creatorcontrib><description>Purpose:
To assess the overall diagnostic accuracy of whole‐body magnetic resonance imaging (WB‐MRI) in detecting bone metastases with a meta‐analysis.
Materials and Methods:
The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB‐MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow‐up for at least 6 months was assessed. Meta‐analysis methods were used to pool sensitivity and specificity and to construct summary receiver‐operating characteristics.
Results:
A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB‐MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845–0.939) and a pooled specificity of 0.918 (95% CI, 0.882–0.946). The subgroup without diffusion‐weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922‐0.984) than the subgroup with DWI (P < 0.05).
Conclusion:
WB‐MRI was an accurate, cost‐effective tool in detecting bone metastases. WB‐MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High‐quality prospective studies regarding WB‐MRI in detecting bone metastases still need to be conducted. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.22608</identifier><identifier>PMID: 21618333</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; bone metastases ; Bone Neoplasms - secondary ; Cost-Benefit Analysis ; diagnostic value ; Humans ; Magnetic Resonance Imaging - methods ; Middle Aged ; Neoplasm Metastasis ; Neoplasms - pathology ; Odds Ratio ; Reproducibility of Results ; ROC Curve ; Whole Body Imaging - methods ; whole-body MRI</subject><ispartof>Journal of magnetic resonance imaging, 2011-07, Vol.34 (1), p.128-135</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4688-237f1cae4dd712fa68f1baea8d93a66b3491061b36606a14af07fd906cbbb293</citedby><cites>FETCH-LOGICAL-c4688-237f1cae4dd712fa68f1baea8d93a66b3491061b36606a14af07fd906cbbb293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.22608$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.22608$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21618333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Lian-Ming</creatorcontrib><creatorcontrib>Gu, Hai-Yan</creatorcontrib><creatorcontrib>Zheng, Jasmine</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Lin, Lin-Hua</creatorcontrib><creatorcontrib>Deng, Xia</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Xu, Jian-Rong</creatorcontrib><title>Diagnostic value of whole-body magnetic resonance imaging for bone metastases: a systematic review and meta-analysis</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To assess the overall diagnostic accuracy of whole‐body magnetic resonance imaging (WB‐MRI) in detecting bone metastases with a meta‐analysis.
Materials and Methods:
The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB‐MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow‐up for at least 6 months was assessed. Meta‐analysis methods were used to pool sensitivity and specificity and to construct summary receiver‐operating characteristics.
Results:
A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB‐MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845–0.939) and a pooled specificity of 0.918 (95% CI, 0.882–0.946). The subgroup without diffusion‐weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922‐0.984) than the subgroup with DWI (P < 0.05).
Conclusion:
WB‐MRI was an accurate, cost‐effective tool in detecting bone metastases. WB‐MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High‐quality prospective studies regarding WB‐MRI in detecting bone metastases still need to be conducted. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>bone metastases</subject><subject>Bone Neoplasms - secondary</subject><subject>Cost-Benefit Analysis</subject><subject>diagnostic value</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms - pathology</subject><subject>Odds Ratio</subject><subject>Reproducibility of Results</subject><subject>ROC Curve</subject><subject>Whole Body Imaging - methods</subject><subject>whole-body MRI</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9P1TAYhxsjEURv_ACmdyYmg_7Zus47gwroQYgh4bJ5u73F4rZCu8Nx394eBlyaNGnT9_n90j6EvOPsgDMmDm-G6A-EUEy_IHu8EqIQlVYv85lVsuCa1bvkdUo3jLGmKatXZFdwxbWUco9MXzxcjyFNvqX30K-RBkc3v0OPhQ3dTIc8xe0wYgojjC1Sn-_8eE1diNSGEemAE6S8MH2iQNOcJhxgydx73FAYuwemgBH6Ofn0huw46BO-fdz3yeW3r5dHJ8Xq_Pj06POqaEuldSFk7XgLWHZdzYUDpR23gKC7RoJSVpYNZ4pbqRRTwEtwrHZdw1RrrRWN3CcfltrbGO7WmCYz-NRi38OIYZ2MrmXNhC635MeFbGNIKaIztzF_M86GM7N1bLaOzYPjDL9_rF3bAbtn9ElqBvgCbHyP83-qzPezX6dPpcWS8dne3-cMxD9G5WdW5urnsZFqdXbx4-rEVPIfEu6YRQ</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Wu, Lian-Ming</creator><creator>Gu, Hai-Yan</creator><creator>Zheng, Jasmine</creator><creator>Xu, Xiao</creator><creator>Lin, Lin-Hua</creator><creator>Deng, Xia</creator><creator>Zhang, Wei</creator><creator>Xu, Jian-Rong</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>Diagnostic value of whole-body magnetic resonance imaging for bone metastases: a systematic review and meta-analysis</title><author>Wu, Lian-Ming ; Gu, Hai-Yan ; Zheng, Jasmine ; Xu, Xiao ; Lin, Lin-Hua ; Deng, Xia ; Zhang, Wei ; Xu, Jian-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4688-237f1cae4dd712fa68f1baea8d93a66b3491061b36606a14af07fd906cbbb293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>bone metastases</topic><topic>Bone Neoplasms - secondary</topic><topic>Cost-Benefit Analysis</topic><topic>diagnostic value</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasms - pathology</topic><topic>Odds Ratio</topic><topic>Reproducibility of Results</topic><topic>ROC Curve</topic><topic>Whole Body Imaging - methods</topic><topic>whole-body MRI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Lian-Ming</creatorcontrib><creatorcontrib>Gu, Hai-Yan</creatorcontrib><creatorcontrib>Zheng, Jasmine</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Lin, Lin-Hua</creatorcontrib><creatorcontrib>Deng, Xia</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Xu, Jian-Rong</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Lian-Ming</au><au>Gu, Hai-Yan</au><au>Zheng, Jasmine</au><au>Xu, Xiao</au><au>Lin, Lin-Hua</au><au>Deng, Xia</au><au>Zhang, Wei</au><au>Xu, Jian-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of whole-body magnetic resonance imaging for bone metastases: a systematic review and meta-analysis</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2011-07</date><risdate>2011</risdate><volume>34</volume><issue>1</issue><spage>128</spage><epage>135</epage><pages>128-135</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To assess the overall diagnostic accuracy of whole‐body magnetic resonance imaging (WB‐MRI) in detecting bone metastases with a meta‐analysis.
Materials and Methods:
The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB‐MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow‐up for at least 6 months was assessed. Meta‐analysis methods were used to pool sensitivity and specificity and to construct summary receiver‐operating characteristics.
Results:
A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB‐MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845–0.939) and a pooled specificity of 0.918 (95% CI, 0.882–0.946). The subgroup without diffusion‐weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922‐0.984) than the subgroup with DWI (P < 0.05).
Conclusion:
WB‐MRI was an accurate, cost‐effective tool in detecting bone metastases. WB‐MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High‐quality prospective studies regarding WB‐MRI in detecting bone metastases still need to be conducted. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21618333</pmid><doi>10.1002/jmri.22608</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content |
| subjects | Adult Aged Aged, 80 and over bone metastases Bone Neoplasms - secondary Cost-Benefit Analysis diagnostic value Humans Magnetic Resonance Imaging - methods Middle Aged Neoplasm Metastasis Neoplasms - pathology Odds Ratio Reproducibility of Results ROC Curve Whole Body Imaging - methods whole-body MRI |
| title | Diagnostic value of whole-body magnetic resonance imaging for bone metastases: a systematic review and meta-analysis |
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