End-Stage Liver Cirrhosis With Severe Autoimmune Hemolytic Anemia, Treated by Blood Type-Incompatible Living Donor Liver Transplantation: A Case Report
Abstract We present a case of successful living donor liver transplantation (LDLT) for liver cirrhosis caused by hepatitis B virus with severe autoimmune hemolytic anemia (AIHA) using an ABO-incompatible (ABOi) graft. The patient was a 47-year-old woman who had a history of ruptured esophageal varic...
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| Veröffentlicht in: | Transplantation proceedings 2011-06, Vol.43 (5), p.2087-2089 |
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| container_title | Transplantation proceedings |
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| creator | Sanefuji, K Ikegami, T Nagata, S Sugimachi, K Gion, T Uchiyama, H Soejima, Y Taketomi, A Shirabe, K Maehara, Y |
| description | Abstract We present a case of successful living donor liver transplantation (LDLT) for liver cirrhosis caused by hepatitis B virus with severe autoimmune hemolytic anemia (AIHA) using an ABO-incompatible (ABOi) graft. The patient was a 47-year-old woman who had a history of ruptured esophageal varices, accumulation of intractable ascites, frequent hepatic encephalopathy and severe anemia, with a hemoglobin value of approximately 3 g/dL due to AIHA. We treated the patient by LDLT using an ABOi liver graft. The treatment strategy included anti-CD20 antibody, plasma exchange and transfusion before LDLT. The patient's anemia improved after surgery; she required only 2 units of irradiated red blood cell concentrates-leukocytes reduced. The patient was discharged from the hospital on postoperative day 35. Two years after surgery, the patient still shows normal hepatic and hematological findings. The immunomodulation protocol for ABOi LDLT was effective not only to avoid humoral reactions associated with ABOi LDLT, but also those associated with AIHA. |
| doi_str_mv | 10.1016/j.transproceed.2011.02.012 |
| format | Article |
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The patient was a 47-year-old woman who had a history of ruptured esophageal varices, accumulation of intractable ascites, frequent hepatic encephalopathy and severe anemia, with a hemoglobin value of approximately 3 g/dL due to AIHA. We treated the patient by LDLT using an ABOi liver graft. The treatment strategy included anti-CD20 antibody, plasma exchange and transfusion before LDLT. The patient's anemia improved after surgery; she required only 2 units of irradiated red blood cell concentrates-leukocytes reduced. The patient was discharged from the hospital on postoperative day 35. Two years after surgery, the patient still shows normal hepatic and hematological findings. The immunomodulation protocol for ABOi LDLT was effective not only to avoid humoral reactions associated with ABOi LDLT, but also those associated with AIHA.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2011.02.012</identifier><identifier>PMID: 21693332</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Anemia, Hemolytic, Autoimmune - complications ; Anemia, Hemolytic, Autoimmune - surgery ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver Cirrhosis - complications ; Liver Cirrhosis - surgery ; Liver Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Living Donors ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Tissue, organ and graft immunology ; Tomography, X-Ray Computed</subject><ispartof>Transplantation proceedings, 2011-06, Vol.43 (5), p.2087-2089</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-bc39428bf6e394aa94b850ea3edd9d134a88da82d0211cc78365ed2ac9d88bca3</citedby><cites>FETCH-LOGICAL-c464t-bc39428bf6e394aa94b850ea3edd9d134a88da82d0211cc78365ed2ac9d88bca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134511003186$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24407622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21693332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanefuji, K</creatorcontrib><creatorcontrib>Ikegami, T</creatorcontrib><creatorcontrib>Nagata, S</creatorcontrib><creatorcontrib>Sugimachi, K</creatorcontrib><creatorcontrib>Gion, T</creatorcontrib><creatorcontrib>Uchiyama, H</creatorcontrib><creatorcontrib>Soejima, Y</creatorcontrib><creatorcontrib>Taketomi, A</creatorcontrib><creatorcontrib>Shirabe, K</creatorcontrib><creatorcontrib>Maehara, Y</creatorcontrib><title>End-Stage Liver Cirrhosis With Severe Autoimmune Hemolytic Anemia, Treated by Blood Type-Incompatible Living Donor Liver Transplantation: A Case Report</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract We present a case of successful living donor liver transplantation (LDLT) for liver cirrhosis caused by hepatitis B virus with severe autoimmune hemolytic anemia (AIHA) using an ABO-incompatible (ABOi) graft. The patient was a 47-year-old woman who had a history of ruptured esophageal varices, accumulation of intractable ascites, frequent hepatic encephalopathy and severe anemia, with a hemoglobin value of approximately 3 g/dL due to AIHA. We treated the patient by LDLT using an ABOi liver graft. The treatment strategy included anti-CD20 antibody, plasma exchange and transfusion before LDLT. The patient's anemia improved after surgery; she required only 2 units of irradiated red blood cell concentrates-leukocytes reduced. The patient was discharged from the hospital on postoperative day 35. Two years after surgery, the patient still shows normal hepatic and hematological findings. The immunomodulation protocol for ABOi LDLT was effective not only to avoid humoral reactions associated with ABOi LDLT, but also those associated with AIHA.</description><subject>Anemia, Hemolytic, Autoimmune - complications</subject><subject>Anemia, Hemolytic, Autoimmune - surgery</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver Transplantation</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Living Donors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver Transplantation</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Living Donors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Tissue, organ and graft immunology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanefuji, K</creatorcontrib><creatorcontrib>Ikegami, T</creatorcontrib><creatorcontrib>Nagata, S</creatorcontrib><creatorcontrib>Sugimachi, K</creatorcontrib><creatorcontrib>Gion, T</creatorcontrib><creatorcontrib>Uchiyama, H</creatorcontrib><creatorcontrib>Soejima, Y</creatorcontrib><creatorcontrib>Taketomi, A</creatorcontrib><creatorcontrib>Shirabe, K</creatorcontrib><creatorcontrib>Maehara, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanefuji, K</au><au>Ikegami, T</au><au>Nagata, S</au><au>Sugimachi, K</au><au>Gion, T</au><au>Uchiyama, H</au><au>Soejima, Y</au><au>Taketomi, A</au><au>Shirabe, K</au><au>Maehara, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>End-Stage Liver Cirrhosis With Severe Autoimmune Hemolytic Anemia, Treated by Blood Type-Incompatible Living Donor Liver Transplantation: A Case Report</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>43</volume><issue>5</issue><spage>2087</spage><epage>2089</epage><pages>2087-2089</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract We present a case of successful living donor liver transplantation (LDLT) for liver cirrhosis caused by hepatitis B virus with severe autoimmune hemolytic anemia (AIHA) using an ABO-incompatible (ABOi) graft. 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| subjects | Anemia, Hemolytic, Autoimmune - complications Anemia, Hemolytic, Autoimmune - surgery Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Cirrhosis - complications Liver Cirrhosis - surgery Liver Transplantation Liver, biliary tract, pancreas, portal circulation, spleen Liver. Biliary tract. Portal circulation. Exocrine pancreas Living Donors Medical sciences Middle Aged Other diseases. Semiology Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue, organ and graft immunology Tomography, X-Ray Computed |
| title | End-Stage Liver Cirrhosis With Severe Autoimmune Hemolytic Anemia, Treated by Blood Type-Incompatible Living Donor Liver Transplantation: A Case Report |
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