Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation
Abstract We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment ( n = 38) or control ( n = 36) groups and eva...
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| Veröffentlicht in: | Transplantation proceedings 2011-06, Vol.43 (5), p.1443-1449 |
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| creator | Danilovic, A Lucon, A.M Srougi, M Shimizu, M.H.M Ianhez, L.E Nahas, W.C Seguro, A.C |
| description | Abstract We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment ( n = 38) or control ( n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days ( P = .026) and at 1 year after transplantation ( P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group ( P = .017) and these recipients required fewer days of dialysis ( P = .012). Oxidative stress was significantly attenuated with NAC ( P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress. |
| doi_str_mv | 10.1016/j.transproceed.2011.02.020 |
| format | Article |
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Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment ( n = 38) or control ( n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days ( P = .026) and at 1 year after transplantation ( P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group ( P = .017) and these recipients required fewer days of dialysis ( P = .012). Oxidative stress was significantly attenuated with NAC ( P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2011.02.020</identifier><identifier>PMID: 21693215</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Acetylcysteine - administration & dosage ; Adult ; Biological and medical sciences ; Cadaver ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Kidney Transplantation ; Male ; Medical sciences ; Middle Aged ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Thiobarbituric Acid Reactive Substances - metabolism ; Tissue Donors ; Tissue, organ and graft immunology</subject><ispartof>Transplantation proceedings, 2011-06, Vol.43 (5), p.1443-1449</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-ba9f0637db567a6ba31d626615712e79e99c908e6a38fb5c2953afc177034ae33</citedby><cites>FETCH-LOGICAL-c516t-ba9f0637db567a6ba31d626615712e79e99c908e6a38fb5c2953afc177034ae33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134511003265$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24407505$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21693215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Danilovic, A</creatorcontrib><creatorcontrib>Lucon, A.M</creatorcontrib><creatorcontrib>Srougi, M</creatorcontrib><creatorcontrib>Shimizu, M.H.M</creatorcontrib><creatorcontrib>Ianhez, L.E</creatorcontrib><creatorcontrib>Nahas, W.C</creatorcontrib><creatorcontrib>Seguro, A.C</creatorcontrib><title>Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment ( n = 38) or control ( n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days ( P = .026) and at 1 year after transplantation ( P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group ( P = .017) and these recipients required fewer days of dialysis ( P = .012). Oxidative stress was significantly attenuated with NAC ( P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress.</description><subject>Acetylcysteine - administration & dosage</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cadaver</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2L1DAUQIMo7rj6F6QI4lPH3KRNpz4IsjurwuKKrg8-hTS9gYydZjdJF_rvvd2ZRfFJuJCEnPvBSRh7BXwNHNTb3TpHM6abGCxivxYcYM0FBX_EVrBpZCmUkI_ZivMKSpBVfcKepbTjdBaVfMpOBKhWCqhX7OfXGDLa7O-w2DpHuyK44ktpLOZ5sHPK6EcswlhsTRzm4mrKNuwxLdQ5WjQJ--IbjmYoru-HGsyYTfZhfM6eODMkfHFcT9mPi-312afy8urj57MPl6WtQeWyM63jSjZ9V6vGqM5I6JVQCuoGBDYttq1t-QaVkRvX1Va0tTTOQtNwWRmU8pS9OdQlH7cTpqz3PlkcaBAMU9Lko6KcqiXy3YG0MaQU0emb6Pcmzhq4Xszqnf7brF7Mai4oOCW_PLaZuj3dPaQ-qCTg9REwyZrBUSHr0x-uqnhT84U7P3BIUu48Rp2sx9Fi7yPp133w_zfP-3_K2MGPnjr_whnTLkyRHiVp0IkS9PflLyxfAYBzKVQtfwPqA7Kt</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Danilovic, A</creator><creator>Lucon, A.M</creator><creator>Srougi, M</creator><creator>Shimizu, M.H.M</creator><creator>Ianhez, L.E</creator><creator>Nahas, W.C</creator><creator>Seguro, A.C</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation</title><author>Danilovic, A ; Lucon, A.M ; Srougi, M ; Shimizu, M.H.M ; Ianhez, L.E ; Nahas, W.C ; Seguro, A.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-ba9f0637db567a6ba31d626615712e79e99c908e6a38fb5c2953afc177034ae33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylcysteine - administration & dosage</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cadaver</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tissue Donors</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Danilovic, A</creatorcontrib><creatorcontrib>Lucon, A.M</creatorcontrib><creatorcontrib>Srougi, M</creatorcontrib><creatorcontrib>Shimizu, M.H.M</creatorcontrib><creatorcontrib>Ianhez, L.E</creatorcontrib><creatorcontrib>Nahas, W.C</creatorcontrib><creatorcontrib>Seguro, A.C</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Danilovic, A</au><au>Lucon, A.M</au><au>Srougi, M</au><au>Shimizu, M.H.M</au><au>Ianhez, L.E</au><au>Nahas, W.C</au><au>Seguro, A.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>43</volume><issue>5</issue><spage>1443</spage><epage>1449</epage><pages>1443-1449</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment ( n = 38) or control ( n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days ( P = .026) and at 1 year after transplantation ( P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group ( P = .017) and these recipients required fewer days of dialysis ( P = .012). 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| subjects | Acetylcysteine - administration & dosage Adult Biological and medical sciences Cadaver Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Kidney Transplantation Male Medical sciences Middle Aged Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Thiobarbituric Acid Reactive Substances - metabolism Tissue Donors Tissue, organ and graft immunology |
| title | Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplantation |
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