Abnormal Bone Quality in Adolescent Idiopathic Scoliosis: A Case-Control Study on 635 Subjects and 269 Normal Controls With Bone Densitometry and Quantitative Ultrasound
A case-control study comparing bone quality in Adolescent Idiopathic Scoliosis (AIS) with normal controls. To evaluate bone quality with quantitative ultrasound (QUS) in AIS and normal controls so as to detect any derangement in bone quality among AIS subjects. AIS is characterized by complex spinal...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2011-07, Vol.36 (15), p.1211-1217 |
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| creator | PING LAM, Tsz WING YIN HUNG, Vivian HIU YAN YEUNG YEE KITTSE CHIU WING CHU, Winnie KIN WAH NG, Bobby KWONG MAN LEE LING QIN CHUN YIU CHENG, Jack |
| description | A case-control study comparing bone quality in Adolescent Idiopathic Scoliosis (AIS) with normal controls.
To evaluate bone quality with quantitative ultrasound (QUS) in AIS and normal controls so as to detect any derangement in bone quality among AIS subjects.
AIS is characterized by complex spinal deformities. Despite its high prevalence and clinical impact in adolescents, etiology of AIS remains unknown but one possible mechanism is related to derangement of bony mechanical stability, as quantified by bone mineral density (BMD) and bone quality. AIS is known for its association with osteopenia, but little is known about the bone quality in AIS. With technological advancement, QUS can provide objective measurement of bone quality. In this study, we sought to compare bone quality in AIS with normal controls using QUS in addition to the conventional BMD measurement.
Six hundred thirty-five AIS girls and 269 age-matched normal girls were investigated. Broadband ultrasound attenuation (BUA), velocity of sound (VOS), and stiffness index (SI) were measured over the nondominant calcaneus using QUS. The results were correlated with anthropometric measurement, radiologic assessment, and BMD of both hips.
The z-score of BMD at the femoral neck of AIS subjects (-0.47 ± 0.97) was significantly lower than that of normal controls (-0.12 ± 1.01, P < 0.001). Crude comparison showed that BUA, VOS, and SI of AIS group were 3.8% (P < 0.01), 0.5% (P = 0.042), and 6.9% (P < 0.01) lower than controls, respectively. After controlling confounding from maturity, body weight, body height, and BMD with multiple linear regression analysis for both mild (Cobb's angle ≤ 25°) and severe (Cobb's angle > 25°) curves, BUA and SI were found to be statistically significantly lower in AIS as compared with controls (P < 0.05).
In addition to higher prevalence of osteopenia, AIS patients were also found to have deranged bone quality. These might contribute to the etiopathogenesis of spinal deformities in AIS. |
| doi_str_mv | 10.1097/BRS.0b013e3181ebab39 |
| format | Article |
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To evaluate bone quality with quantitative ultrasound (QUS) in AIS and normal controls so as to detect any derangement in bone quality among AIS subjects.
AIS is characterized by complex spinal deformities. Despite its high prevalence and clinical impact in adolescents, etiology of AIS remains unknown but one possible mechanism is related to derangement of bony mechanical stability, as quantified by bone mineral density (BMD) and bone quality. AIS is known for its association with osteopenia, but little is known about the bone quality in AIS. With technological advancement, QUS can provide objective measurement of bone quality. In this study, we sought to compare bone quality in AIS with normal controls using QUS in addition to the conventional BMD measurement.
Six hundred thirty-five AIS girls and 269 age-matched normal girls were investigated. Broadband ultrasound attenuation (BUA), velocity of sound (VOS), and stiffness index (SI) were measured over the nondominant calcaneus using QUS. The results were correlated with anthropometric measurement, radiologic assessment, and BMD of both hips.
The z-score of BMD at the femoral neck of AIS subjects (-0.47 ± 0.97) was significantly lower than that of normal controls (-0.12 ± 1.01, P < 0.001). Crude comparison showed that BUA, VOS, and SI of AIS group were 3.8% (P < 0.01), 0.5% (P = 0.042), and 6.9% (P < 0.01) lower than controls, respectively. After controlling confounding from maturity, body weight, body height, and BMD with multiple linear regression analysis for both mild (Cobb's angle ≤ 25°) and severe (Cobb's angle > 25°) curves, BUA and SI were found to be statistically significantly lower in AIS as compared with controls (P < 0.05).
In addition to higher prevalence of osteopenia, AIS patients were also found to have deranged bone quality. These might contribute to the etiopathogenesis of spinal deformities in AIS.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/BRS.0b013e3181ebab39</identifier><identifier>PMID: 21217455</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Absorptiometry, Photon ; Adolescent ; Biological and medical sciences ; Body Height ; Body Weight ; Bone and Bones ; Bone Density ; Case-Control Studies ; Cerebrospinal fluid. Meninges. Spinal cord ; Child ; Female ; Femur Neck - diagnostic imaging ; Humans ; Linear Models ; Medical sciences ; Multivariate Analysis ; Nervous system (semeiology, syndromes) ; Neurology ; Scoliosis - diagnostic imaging ; Tumors of the nervous system. Phacomatoses ; Ultrasonography</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2011-07, Vol.36 (15), p.1211-1217</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c229t-8f50322ae7bef2f9270b648ea3cebbdf9decfd8d11b0bca0e1bc3e588b69b0cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24336153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21217455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PING LAM, Tsz</creatorcontrib><creatorcontrib>WING YIN HUNG, Vivian</creatorcontrib><creatorcontrib>HIU YAN YEUNG</creatorcontrib><creatorcontrib>YEE KITTSE</creatorcontrib><creatorcontrib>CHIU WING CHU, Winnie</creatorcontrib><creatorcontrib>KIN WAH NG, Bobby</creatorcontrib><creatorcontrib>KWONG MAN LEE</creatorcontrib><creatorcontrib>LING QIN</creatorcontrib><creatorcontrib>CHUN YIU CHENG, Jack</creatorcontrib><title>Abnormal Bone Quality in Adolescent Idiopathic Scoliosis: A Case-Control Study on 635 Subjects and 269 Normal Controls With Bone Densitometry and Quantitative Ultrasound</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>A case-control study comparing bone quality in Adolescent Idiopathic Scoliosis (AIS) with normal controls.
To evaluate bone quality with quantitative ultrasound (QUS) in AIS and normal controls so as to detect any derangement in bone quality among AIS subjects.
AIS is characterized by complex spinal deformities. Despite its high prevalence and clinical impact in adolescents, etiology of AIS remains unknown but one possible mechanism is related to derangement of bony mechanical stability, as quantified by bone mineral density (BMD) and bone quality. AIS is known for its association with osteopenia, but little is known about the bone quality in AIS. With technological advancement, QUS can provide objective measurement of bone quality. In this study, we sought to compare bone quality in AIS with normal controls using QUS in addition to the conventional BMD measurement.
Six hundred thirty-five AIS girls and 269 age-matched normal girls were investigated. Broadband ultrasound attenuation (BUA), velocity of sound (VOS), and stiffness index (SI) were measured over the nondominant calcaneus using QUS. The results were correlated with anthropometric measurement, radiologic assessment, and BMD of both hips.
The z-score of BMD at the femoral neck of AIS subjects (-0.47 ± 0.97) was significantly lower than that of normal controls (-0.12 ± 1.01, P < 0.001). Crude comparison showed that BUA, VOS, and SI of AIS group were 3.8% (P < 0.01), 0.5% (P = 0.042), and 6.9% (P < 0.01) lower than controls, respectively. After controlling confounding from maturity, body weight, body height, and BMD with multiple linear regression analysis for both mild (Cobb's angle ≤ 25°) and severe (Cobb's angle > 25°) curves, BUA and SI were found to be statistically significantly lower in AIS as compared with controls (P < 0.05).
In addition to higher prevalence of osteopenia, AIS patients were also found to have deranged bone quality. These might contribute to the etiopathogenesis of spinal deformities in AIS.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Bone and Bones</subject><subject>Bone Density</subject><subject>Case-Control Studies</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Child</subject><subject>Female</subject><subject>Femur Neck - diagnostic imaging</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Scoliosis - diagnostic imaging</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Ultrasonography</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1DAUhq2qiE4H3gAhbypWKb4kTtzddChQqaKCoeoy8uVEdeXYg-0gzSPxlqTMQCVWZ_P95z86H0JvKDmnRLbvL79tzokmlAOnHQWtNJdHaEEb1lWUNvIYLQgXrGI1FyfoNOdHQojgVL5EJ4wy2tZNs0C_VjrENCqPL2MA_HVS3pUddgGvbPSQDYSCr62LW1UenMEbE72L2eULvMJrlaFax1BS9HhTJrvDMWDBG7yZ9COYkrEKFjMh8Zd9yQHO-N6Vh33lBwjZlThCSbs_-HxDKK6o4n4CvvMlqRynYF-hF4PyGV4f5hLdfbz6vv5c3dx-ul6vbirDmCxVNzSEM6ag1TCwQbKWaFF3oLgBre0gLZjBdpZSTbRRBKg2HJqu00JqYgxfonf7vdsUf0yQSz-6-Q3eqwBxyn3X8lrWYn78EtV70qSYc4Kh3yY3qrTrKemfHPWzo_5_R3Ps7aFg0iPYf6G_Umbg7ACobJQfkgrG5Weu5lzQhvPfStGe_Q</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>PING LAM, Tsz</creator><creator>WING YIN HUNG, Vivian</creator><creator>HIU YAN YEUNG</creator><creator>YEE KITTSE</creator><creator>CHIU WING CHU, Winnie</creator><creator>KIN WAH NG, Bobby</creator><creator>KWONG MAN LEE</creator><creator>LING QIN</creator><creator>CHUN YIU CHENG, Jack</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Abnormal Bone Quality in Adolescent Idiopathic Scoliosis: A Case-Control Study on 635 Subjects and 269 Normal Controls With Bone Densitometry and Quantitative Ultrasound</title><author>PING LAM, Tsz ; WING YIN HUNG, Vivian ; HIU YAN YEUNG ; YEE KITTSE ; CHIU WING CHU, Winnie ; KIN WAH NG, Bobby ; KWONG MAN LEE ; LING QIN ; CHUN YIU CHENG, Jack</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c229t-8f50322ae7bef2f9270b648ea3cebbdf9decfd8d11b0bca0e1bc3e588b69b0cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Bone and Bones</topic><topic>Bone Density</topic><topic>Case-Control Studies</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Child</topic><topic>Female</topic><topic>Femur Neck - diagnostic imaging</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Scoliosis - diagnostic imaging</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PING LAM, Tsz</creatorcontrib><creatorcontrib>WING YIN HUNG, Vivian</creatorcontrib><creatorcontrib>HIU YAN YEUNG</creatorcontrib><creatorcontrib>YEE KITTSE</creatorcontrib><creatorcontrib>CHIU WING CHU, Winnie</creatorcontrib><creatorcontrib>KIN WAH NG, Bobby</creatorcontrib><creatorcontrib>KWONG MAN LEE</creatorcontrib><creatorcontrib>LING QIN</creatorcontrib><creatorcontrib>CHUN YIU CHENG, Jack</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PING LAM, Tsz</au><au>WING YIN HUNG, Vivian</au><au>HIU YAN YEUNG</au><au>YEE KITTSE</au><au>CHIU WING CHU, Winnie</au><au>KIN WAH NG, Bobby</au><au>KWONG MAN LEE</au><au>LING QIN</au><au>CHUN YIU CHENG, Jack</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal Bone Quality in Adolescent Idiopathic Scoliosis: A Case-Control Study on 635 Subjects and 269 Normal Controls With Bone Densitometry and Quantitative Ultrasound</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>36</volume><issue>15</issue><spage>1211</spage><epage>1217</epage><pages>1211-1217</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>A case-control study comparing bone quality in Adolescent Idiopathic Scoliosis (AIS) with normal controls.
To evaluate bone quality with quantitative ultrasound (QUS) in AIS and normal controls so as to detect any derangement in bone quality among AIS subjects.
AIS is characterized by complex spinal deformities. Despite its high prevalence and clinical impact in adolescents, etiology of AIS remains unknown but one possible mechanism is related to derangement of bony mechanical stability, as quantified by bone mineral density (BMD) and bone quality. AIS is known for its association with osteopenia, but little is known about the bone quality in AIS. With technological advancement, QUS can provide objective measurement of bone quality. In this study, we sought to compare bone quality in AIS with normal controls using QUS in addition to the conventional BMD measurement.
Six hundred thirty-five AIS girls and 269 age-matched normal girls were investigated. Broadband ultrasound attenuation (BUA), velocity of sound (VOS), and stiffness index (SI) were measured over the nondominant calcaneus using QUS. The results were correlated with anthropometric measurement, radiologic assessment, and BMD of both hips.
The z-score of BMD at the femoral neck of AIS subjects (-0.47 ± 0.97) was significantly lower than that of normal controls (-0.12 ± 1.01, P < 0.001). Crude comparison showed that BUA, VOS, and SI of AIS group were 3.8% (P < 0.01), 0.5% (P = 0.042), and 6.9% (P < 0.01) lower than controls, respectively. After controlling confounding from maturity, body weight, body height, and BMD with multiple linear regression analysis for both mild (Cobb's angle ≤ 25°) and severe (Cobb's angle > 25°) curves, BUA and SI were found to be statistically significantly lower in AIS as compared with controls (P < 0.05).
In addition to higher prevalence of osteopenia, AIS patients were also found to have deranged bone quality. These might contribute to the etiopathogenesis of spinal deformities in AIS.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21217455</pmid><doi>10.1097/BRS.0b013e3181ebab39</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 2011-07, Vol.36 (15), p.1211-1217 |
| issn | 0362-2436 1528-1159 |
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| subjects | Absorptiometry, Photon Adolescent Biological and medical sciences Body Height Body Weight Bone and Bones Bone Density Case-Control Studies Cerebrospinal fluid. Meninges. Spinal cord Child Female Femur Neck - diagnostic imaging Humans Linear Models Medical sciences Multivariate Analysis Nervous system (semeiology, syndromes) Neurology Scoliosis - diagnostic imaging Tumors of the nervous system. Phacomatoses Ultrasonography |
| title | Abnormal Bone Quality in Adolescent Idiopathic Scoliosis: A Case-Control Study on 635 Subjects and 269 Normal Controls With Bone Densitometry and Quantitative Ultrasound |
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