Relaxation of the resolution requirements for direct-methods phasing
Shake‐and‐bake phasing methods have permitted the ab initio solution of crystal structures containing more than 1000 independent non‐H light atoms (C, N, O). The success of these procedures is critically dependent upon having diffraction data measured to at least 1.2 Å resolution. A new target funct...
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| Veröffentlicht in: | Acta crystallographica. Section A, Foundations of crystallography Foundations of crystallography, 2011-07, Vol.67 (4), p.396-401 |
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| container_title | Acta crystallographica. Section A, Foundations of crystallography |
| container_volume | 67 |
| creator | Langs, David A. Hauptman, Herbert A. |
| description | Shake‐and‐bake phasing methods have permitted the ab initio solution of crystal structures containing more than 1000 independent non‐H light atoms (C, N, O). The success of these procedures is critically dependent upon having diffraction data measured to at least 1.2 Å resolution. A new target function R2(ϕh) is introduced into the shake‐and‐bake procedure along with a real difference map strategy whereby this resolution limit can be appreciably lowered toward 1.5 Å. These improvements, when applied to moderately high resolution data, may now allow one the possibility to solve structures that are twice as large as could have been solved previously. |
| doi_str_mv | 10.1107/S0108767311013560 |
| format | Article |
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| ispartof | Acta crystallographica. Section A, Foundations of crystallography, 2011-07, Vol.67 (4), p.396-401 |
| issn | 0108-7673 1600-5724 2053-2733 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_873494389 |
| source | Wiley Online Library - AutoHoldings Journals; Alma/SFX Local Collection |
| subjects | Atomic structure Atoms & subatomic particles Crystal structure Crystallography Diffraction direct phasing methods High resolution Phasing Strategy |
| title | Relaxation of the resolution requirements for direct-methods phasing |
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