Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof

: The ‘matrikine’ concept claims that processing of the precursors for collagen results in the formation of peptides such as KTTKS which in turn augments extracellular matrix (ECM) production. In the present study, we show the development of an anti‐ageing active from an in silico approach by molec...

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Veröffentlicht in:	Experimental dermatology 2011-07, Vol.20 (7), p.602-604
Hauptverfasser:	Farwick, Mike, Grether-Beck, Susanne, Marini, Alessandra, Maczkiewitz, Ursula, Lange, Jennifer, Köhler, Tim, Lersch, Peter, Falla, Tim, Felsner, Ingo, Brenden, Heidi, Jaenicke, Thomas, Franke, Susanne, Krutmann, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ageing Biological and medical sciences Cells, Cultured collagen Collagen Type I - genetics Collagen Type I - metabolism Dermatologic Agents - pharmacology Dermatologic Agents - therapeutic use Dermatology Double-Blind Method Elasticity - drug effects Extracellular Matrix - metabolism Fibroblasts - drug effects Fibroblasts - metabolism fibronectin Fibronectins - genetics Fibronectins - metabolism GEKG Gene Expression - genetics Glucuronosyltransferase - genetics Humans hyaluronan Hyaluronan Synthases Hyaluronic Acid - metabolism matrix Medical sciences Oligopeptides - pharmacology Oligopeptides - therapeutic use Procollagen - metabolism Skin - drug effects Skin - metabolism Skin Aging - drug effects Skin Physiological Phenomena - drug effects
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