Protective Role of Akt2 in Salmonella enterica Serovar Typhimurium-Induced Gastroenterocolitis

The Salmonella effector protein SopB has previously been shown to induce activation of Akt and protect epithelial cells from apoptosis in vitro. To characterize the role of Akt2 in host defense against Salmonella enterica serovar Typhimurium infection, wild-type (WT) mice and mice lacking Akt2 (Akt2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Infection and Immunity 2011-07, Vol.79 (7), p.2554-2566
Hauptverfasser:	Kum, Winnie W.S, Lo, Bernard C, Yu, Hong B, Finlay, B. Brett
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A5 - analysis Apoptosis Bacterial Load Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences cecum Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Chemokine CCL2 - analysis Colitis - immunology Colitis - microbiology Colitis - pathology epithelial cells Flow Cytometry Fundamental and applied biological sciences. Psychology gastroenteritis Gastroenteritis - immunology Gastroenteritis - microbiology Gastroenteritis - pathology histopathology immunohistochemistry In Situ Nick-End Labeling inflammation interferon-gamma Interferon-gamma - analysis Intestines - microbiology macrophages Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Mice Mice, Knockout microbial load Microbiology Miscellaneous morbidity mortality mutants Neutrophil Infiltration neutrophils Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Salmonella enterica subsp. enterica serovar Typhimurium Salmonella Infections, Animal - immunology Salmonella Infections, Animal - microbiology Salmonella Infections, Animal - pathology Salmonella typhimurium - genetics Salmonella typhimurium - immunology Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity salmonellosis serotypes tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!