Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis

Several lines of evidence suggest that in mice the activation of SMAD2/3 signaling by oocyte secreted factors, together with epidermal growth factor receptor (EGFR) activation, is essential to induce cumulus expansion. Here we show that inhibition of EGFR kinase in follicle stimulating hormone (FSH)...

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Veröffentlicht in:	Molecular reproduction and development 2011-06, Vol.78 (6), p.391-402
Hauptverfasser:	Nagyova, Eva, Camaioni, Antonella, Scsukova, Sona, Mlynarcikova, Alzbeta, Prochazka, Radek, Nemcova, Lucie, Salustri, Antonietta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacology Biological and medical sciences C-Reactive Protein - metabolism Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - metabolism Cumulus Cells - metabolism Dioxoles - pharmacology Epidermal Growth Factor - metabolism Female Follicle Stimulating Hormone - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Glucuronosyltransferase - antagonists & inhibitors Glucuronosyltransferase - metabolism Hormone metabolism and regulation hyaluronan Hyaluronic Acid - biosynthesis Isoquinolines - pharmacology Mammalian female genital system Meiosis - drug effects Mice oocyte-cumulus complex Oocytes - enzymology Oocytes - physiology progesterone Progesterone - biosynthesis Pyridines - pharmacology Pyrroles - pharmacology Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Serum Amyloid P-Component - metabolism Signal Transduction - drug effects Smad2 Protein - antagonists & inhibitors Smad2 Protein - metabolism Smad3 Protein - antagonists & inhibitors Smad3 Protein - metabolism Swine Tyrphostins - pharmacology Vertebrates: reproduction
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