Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling–Isoxazole Fragmentation

A one-pot protocol for the cyanomethylation of aryl halides through a palladium-catalyzed reaction with isoxazole-4-boronic acid pinacol ester was developed. Mechanistically, the reaction proceeds through (1) Suzuki coupling, (2) base-induced fragmentation, and (3) deformylation as shown by characte...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-05, Vol.133 (18), p.6948-6951
Hauptverfasser:	Velcicky, Juraj, Soicke, Arne, Steiner, Roland, Schmalz, Hans-Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles - chemical synthesis Boronic Acids - chemistry Bromides - chemistry Catalysis Isoxazoles - chemistry Methylation Palladium - chemistry
Online-Zugang:	Volltext
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