CpG island methylation profiling in human salivary gland adenoid cystic carcinoma

BACKGROUND: DNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at active gene promoters leads to transcriptional repression, whereas hypomethylation is associated with gene overexpression. The aim...

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Veröffentlicht in:	Cancer 2011-07, Vol.117 (13), p.2898-2909
Hauptverfasser:	Bell, Achim, Bell, Diana, Weber, Randal S., El‐Naggar, Adel K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoid adenoid cystic carcinoma Adult Aged Apoptosis Base Sequence Biological and medical sciences biomarkers Carcinoma Carcinoma, Adenoid Cystic - genetics CpG island methylation CpG islands CpG Islands - genetics DNA Methylation DNA microarrays epigenetics Female Gene Expression Regulation, Neoplastic Gene silencing Humans Male Medical sciences methylated CpG island amplification and microarray Middle Aged Nkx2.5 protein Oligonucleotide Array Sequence Analysis Otorhinolaryngology. Stomatology Polymerase Chain Reaction Promoter Regions, Genetic Promoters pyrosequencing Salivary gland Salivary Gland Neoplasms - genetics Sequence Analysis, DNA Transcription factors Transcription Factors - chemistry Transcription Factors - genetics Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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