The Diamidine Diminazene Aceturate Is a Substrate for the High-Affinity Pentamidine Transporter: Implications for the Development of High Resistance Levels in Trypanosomes

African trypanosomiasis is a disease of humans and livestock in many areas south of the Sahara. Resistance to the few existing drugs is a major impediment to the control of these diseases, and we investigated how resistance to the main veterinary drug diminazene aceturate correlates with changes in...

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Veröffentlicht in:	Molecular pharmacology 2011-07, Vol.80 (1), p.110-116
Hauptverfasser:	Teka, Ibrahim A., Kazibwe, Anne J.N., El-Sabbagh, Nasser, Al-Salabi, Mohammed I., Ward, Christopher P., Eze, Anthonius A., Munday, Jane C., Mäser, Pascal, Matovu, Enock, Barrett, Michael P., de Koning, Harry P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - drug effects Diminazene - pharmacology Pentamidine - metabolism Trypanocidal Agents - pharmacology Trypanosoma brucei brucei Trypanosoma brucei brucei - drug effects
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