Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract
Purpose To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract. Patients and Methods Forty-seven patients (median age, 69 years; range, 43–82 years) who had HCC located within 2 cm of the alimentary tract underwent...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2011-07, Vol.80 (4), p.992-995 |
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| creator | Nakayama, Hidetsugu, M.D Sugahara, Shinji, M.D Fukuda, Kuniaki, M.D Abei, Masato, M.D Shoda, Junichi, M.D Sakurai, Hideyuki, M.D Tsuboi, Koji, M.D Matsuzaki, Yasushi, M.D Tokuuye, Koichi, M.D., Ph.D |
| description | Purpose To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract. Patients and Methods Forty-seven patients (median age, 69 years; range, 43–82 years) who had HCC located within 2 cm of the alimentary tract underwent proton beam therapy. Liver damage according to the Child-Pugh classification was Class A in 35 patients, Class B in 9, and Class C in 3. Treatment protocols of the early 16 patients and the late 31 patients were 72.6 GyE in 22 fractions and 77 GyE in 35 fractions, respectively. Results During the median follow-up period of 23 months, 24 patients died; the remaining 23 patients were alive until September 2008. The median overall survival was 33.9 months (95% confidence interval [CI], 10.8–57.0 months). Actuarial overall and local progression-free survival rates at 3 years were 50.0% and 88.1%, respectively. Grade 2 and 3 alimentary tract hemorrhage was observed in 3 (6.4%) and 1 (2.1%) patients, respectively. Conclusions Our proton beam therapy strategy for HCC located adjacent to the alimentary tract seems to be effective but should be performed with caution. |
| doi_str_mv | 10.1016/j.ijrobp.2010.03.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_873120531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0360301610004207</els_id><sourcerecordid>873120531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c512t-c153e745b26b30190b38a3ab031bf7b6f84b774a8687d4660589482a55c659be3</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7uzqPxDJRTz1mM9Oz0WYHXRXGFBwBD2FJF3Npu3ujElamH9vmhkVvHgKFZ6qenkKoReUrCmh9Zt-7fsY7HHNSPkifE2ofIRWtFGbikv59TFaEV6Tihf4Cl2n1BNCKFXiKbpiVApOa7ZC3z7FkMOEb8GM-PAA0RxPuAsR38PR5OBgGObBRLwz0fkpjAbvgzMZWrxte-NgyjgHnB8Abwc_ltLEEz5E4_Iz9KQzQ4Lnl_cGfXn_7rC7r_Yf7z7stvvKScpy5ajkoIS0rLYl6oZY3hhuLOHUdsrWXSOsUsI0daNaUddENhvRMCOlq-XGAr9Br89zjzH8mCFlPfq05DYThDnpRnHKiOS0kOJMuhhSitDpY_RjCawp0YtT3euzU7041YTr4rS0vbwsmO0I7Z-m3xIL8OoCmOTM0EUzOZ_-coIzJQUp3NszB0XHTw9RJ-dhctD6CC7rNvj_Jfl3gBv85MvO73CC1Ic5TkW1pjoxTfTn5f7L-Wm5vGBE8V8WN6ox</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>873120531</pqid></control><display><type>article</type><title>Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Nakayama, Hidetsugu, M.D ; Sugahara, Shinji, M.D ; Fukuda, Kuniaki, M.D ; Abei, Masato, M.D ; Shoda, Junichi, M.D ; Sakurai, Hideyuki, M.D ; Tsuboi, Koji, M.D ; Matsuzaki, Yasushi, M.D ; Tokuuye, Koichi, M.D., Ph.D</creator><creatorcontrib>Nakayama, Hidetsugu, M.D ; Sugahara, Shinji, M.D ; Fukuda, Kuniaki, M.D ; Abei, Masato, M.D ; Shoda, Junichi, M.D ; Sakurai, Hideyuki, M.D ; Tsuboi, Koji, M.D ; Matsuzaki, Yasushi, M.D ; Tokuuye, Koichi, M.D., Ph.D</creatorcontrib><description>Purpose To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract. Patients and Methods Forty-seven patients (median age, 69 years; range, 43–82 years) who had HCC located within 2 cm of the alimentary tract underwent proton beam therapy. Liver damage according to the Child-Pugh classification was Class A in 35 patients, Class B in 9, and Class C in 3. Treatment protocols of the early 16 patients and the late 31 patients were 72.6 GyE in 22 fractions and 77 GyE in 35 fractions, respectively. Results During the median follow-up period of 23 months, 24 patients died; the remaining 23 patients were alive until September 2008. The median overall survival was 33.9 months (95% confidence interval [CI], 10.8–57.0 months). Actuarial overall and local progression-free survival rates at 3 years were 50.0% and 88.1%, respectively. Grade 2 and 3 alimentary tract hemorrhage was observed in 3 (6.4%) and 1 (2.1%) patients, respectively. Conclusions Our proton beam therapy strategy for HCC located adjacent to the alimentary tract seems to be effective but should be performed with caution.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2010.03.015</identifier><identifier>PMID: 21543162</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - radiotherapy ; Digestive System - radiation effects ; Dose Fractionation ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal bleeding ; Gastrointestinal Hemorrhage - etiology ; Hematology, Oncology and Palliative Medicine ; Hepatocellular carcinoma ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - radiotherapy ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Proton beam therapy ; Protons - therapeutic use ; Radiology ; Tumors</subject><ispartof>International journal of radiation oncology, biology, physics, 2011-07, Vol.80 (4), p.992-995</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-c153e745b26b30190b38a3ab031bf7b6f84b774a8687d4660589482a55c659be3</citedby><cites>FETCH-LOGICAL-c512t-c153e745b26b30190b38a3ab031bf7b6f84b774a8687d4660589482a55c659be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301610004207$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24327540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21543162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakayama, Hidetsugu, M.D</creatorcontrib><creatorcontrib>Sugahara, Shinji, M.D</creatorcontrib><creatorcontrib>Fukuda, Kuniaki, M.D</creatorcontrib><creatorcontrib>Abei, Masato, M.D</creatorcontrib><creatorcontrib>Shoda, Junichi, M.D</creatorcontrib><creatorcontrib>Sakurai, Hideyuki, M.D</creatorcontrib><creatorcontrib>Tsuboi, Koji, M.D</creatorcontrib><creatorcontrib>Matsuzaki, Yasushi, M.D</creatorcontrib><creatorcontrib>Tokuuye, Koichi, M.D., Ph.D</creatorcontrib><title>Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract. Patients and Methods Forty-seven patients (median age, 69 years; range, 43–82 years) who had HCC located within 2 cm of the alimentary tract underwent proton beam therapy. Liver damage according to the Child-Pugh classification was Class A in 35 patients, Class B in 9, and Class C in 3. Treatment protocols of the early 16 patients and the late 31 patients were 72.6 GyE in 22 fractions and 77 GyE in 35 fractions, respectively. Results During the median follow-up period of 23 months, 24 patients died; the remaining 23 patients were alive until September 2008. The median overall survival was 33.9 months (95% confidence interval [CI], 10.8–57.0 months). Actuarial overall and local progression-free survival rates at 3 years were 50.0% and 88.1%, respectively. Grade 2 and 3 alimentary tract hemorrhage was observed in 3 (6.4%) and 1 (2.1%) patients, respectively. Conclusions Our proton beam therapy strategy for HCC located adjacent to the alimentary tract seems to be effective but should be performed with caution.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - radiotherapy</subject><subject>Digestive System - radiation effects</subject><subject>Dose Fractionation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal bleeding</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - radiotherapy</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Proton beam therapy</subject><subject>Protons - therapeutic use</subject><subject>Radiology</subject><subject>Tumors</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7uzqPxDJRTz1mM9Oz0WYHXRXGFBwBD2FJF3Npu3ujElamH9vmhkVvHgKFZ6qenkKoReUrCmh9Zt-7fsY7HHNSPkifE2ofIRWtFGbikv59TFaEV6Tihf4Cl2n1BNCKFXiKbpiVApOa7ZC3z7FkMOEb8GM-PAA0RxPuAsR38PR5OBgGObBRLwz0fkpjAbvgzMZWrxte-NgyjgHnB8Abwc_ltLEEz5E4_Iz9KQzQ4Lnl_cGfXn_7rC7r_Yf7z7stvvKScpy5ajkoIS0rLYl6oZY3hhuLOHUdsrWXSOsUsI0daNaUddENhvRMCOlq-XGAr9Br89zjzH8mCFlPfq05DYThDnpRnHKiOS0kOJMuhhSitDpY_RjCawp0YtT3euzU7041YTr4rS0vbwsmO0I7Z-m3xIL8OoCmOTM0EUzOZ_-coIzJQUp3NszB0XHTw9RJ-dhctD6CC7rNvj_Jfl3gBv85MvO73CC1Ic5TkW1pjoxTfTn5f7L-Wm5vGBE8V8WN6ox</recordid><startdate>20110715</startdate><enddate>20110715</enddate><creator>Nakayama, Hidetsugu, M.D</creator><creator>Sugahara, Shinji, M.D</creator><creator>Fukuda, Kuniaki, M.D</creator><creator>Abei, Masato, M.D</creator><creator>Shoda, Junichi, M.D</creator><creator>Sakurai, Hideyuki, M.D</creator><creator>Tsuboi, Koji, M.D</creator><creator>Matsuzaki, Yasushi, M.D</creator><creator>Tokuuye, Koichi, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110715</creationdate><title>Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract</title><author>Nakayama, Hidetsugu, M.D ; Sugahara, Shinji, M.D ; Fukuda, Kuniaki, M.D ; Abei, Masato, M.D ; Shoda, Junichi, M.D ; Sakurai, Hideyuki, M.D ; Tsuboi, Koji, M.D ; Matsuzaki, Yasushi, M.D ; Tokuuye, Koichi, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-c153e745b26b30190b38a3ab031bf7b6f84b774a8687d4660589482a55c659be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - radiotherapy</topic><topic>Digestive System - radiation effects</topic><topic>Dose Fractionation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal bleeding</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - radiotherapy</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Proton beam therapy</topic><topic>Protons - therapeutic use</topic><topic>Radiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Hidetsugu, M.D</creatorcontrib><creatorcontrib>Sugahara, Shinji, M.D</creatorcontrib><creatorcontrib>Fukuda, Kuniaki, M.D</creatorcontrib><creatorcontrib>Abei, Masato, M.D</creatorcontrib><creatorcontrib>Shoda, Junichi, M.D</creatorcontrib><creatorcontrib>Sakurai, Hideyuki, M.D</creatorcontrib><creatorcontrib>Tsuboi, Koji, M.D</creatorcontrib><creatorcontrib>Matsuzaki, Yasushi, M.D</creatorcontrib><creatorcontrib>Tokuuye, Koichi, M.D., Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Hidetsugu, M.D</au><au>Sugahara, Shinji, M.D</au><au>Fukuda, Kuniaki, M.D</au><au>Abei, Masato, M.D</au><au>Shoda, Junichi, M.D</au><au>Sakurai, Hideyuki, M.D</au><au>Tsuboi, Koji, M.D</au><au>Matsuzaki, Yasushi, M.D</au><au>Tokuuye, Koichi, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2011-07-15</date><risdate>2011</risdate><volume>80</volume><issue>4</issue><spage>992</spage><epage>995</epage><pages>992-995</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract. Patients and Methods Forty-seven patients (median age, 69 years; range, 43–82 years) who had HCC located within 2 cm of the alimentary tract underwent proton beam therapy. Liver damage according to the Child-Pugh classification was Class A in 35 patients, Class B in 9, and Class C in 3. Treatment protocols of the early 16 patients and the late 31 patients were 72.6 GyE in 22 fractions and 77 GyE in 35 fractions, respectively. Results During the median follow-up period of 23 months, 24 patients died; the remaining 23 patients were alive until September 2008. The median overall survival was 33.9 months (95% confidence interval [CI], 10.8–57.0 months). Actuarial overall and local progression-free survival rates at 3 years were 50.0% and 88.1%, respectively. Grade 2 and 3 alimentary tract hemorrhage was observed in 3 (6.4%) and 1 (2.1%) patients, respectively. Conclusions Our proton beam therapy strategy for HCC located adjacent to the alimentary tract seems to be effective but should be performed with caution.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21543162</pmid><doi>10.1016/j.ijrobp.2010.03.015</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - radiotherapy Digestive System - radiation effects Dose Fractionation Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal bleeding Gastrointestinal Hemorrhage - etiology Hematology, Oncology and Palliative Medicine Hepatocellular carcinoma Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - radiotherapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Prospective Studies Proton beam therapy Protons - therapeutic use Radiology Tumors |
| title | Proton Beam Therapy for Hepatocellular Carcinoma Located Adjacent to the Alimentary Tract |
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